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A new study published in the journal Cells shows for the first time that a specific gene called VGLL4 is necessary for embryonic development but is indispensable for myocardial growth
.
Important Causes: Congenital heart disease is one of the leading causes of morbidity and mortality in children, which is why it is important
to decipher the molecular mechanisms that control the development of the heart.
"Vestigial like family member 4" is a protein encoded by the VGLL4 gene; This is a transcriptional cofactor of the VGLL family and is present in many organs and tissues
.
STUDY SUMMARY: To understand the function of VGLL4 in the heart, the authors generated two mouse lines with VGLL4 loss function: a germline VGLL4 depletion allele and a cardiomyocyte-specific VGLL4 depletion allele
.
New Discovery: This is a newly discovered function about VGLL4; This protein is necessary for embryonic development, but its function is independent and isolated from the growth of the myocardial wall of the
heart.
essay
Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development
