A new drug can destroy the biological clock of cancer cells.

Researchers at the University of Southern California and Nagoya University in Japan have teamed up to develop a new drug that can inhibit cancer cell growth by destroying the biological clock of cancer cells.
it is well known that disrupting the rhythm of the biological clock can harm human health, as well as the biological clock of cells.
could theoretically damage or destroy cancer cells if they disrupt the biological clock.
team reports in the new issue of the American Journal of Science Advances that they have studied cancer cells in human kidney cancer and acute myeloid leukemia in mice.
found that a molecule called GO289 can slow down the growth cycle of cancer cells by blocking the biological clock, with little effect on healthy cells.
researchers say go289 interacts with an enzyme that controls the cell's biological clock, which can disrupt the function of four other proteins that are critical to cell growth and survival. In some cancers, disease controls the biological clock mechanism and stimulates cancer cell growth, and GO289 can interfere with these processes and stop the development of cancer, said Steve Kay, director of the Maxon Center for Biological Sciences at the University of
, a drug that "could be an effective new weapon in eliminating cancer."
Related Information: Does the skin really have a biological clock? Recently, a "skin biological clock timetable" was circulated online.
for example, the schedule says that cells grow and repair the most from 11 p.m. to 5 a.m., that cell division is about eight times faster than usual, and that skin absorbs skin care products particularly strongly.
the schedule says it's time to use a nutrient-rich moisturizer cream to maximize maintenance. does
seemingly justified "skin biological clock" really have a scientific basis? Today we asked Liu Wei, director of the Dermatology Hospital of the Air Force General Hospital, to uncover the truth.
overall, the so-called "skin clock schedule" has no reliable scientific basis and is not recommended for skin care, which is unscientific and too dogmatic.
first, "11 p.m. to 5 a.m., when cells grow and repair the most" is the opposite of medical common sense.
at this time the human body into sleep, human tissue cell metabolism is very slow, the skin of high nutritional components of the face cream absorption capacity is not stronger than during the day.
the "skin biological clock schedule" circulating on the Internet also said that "1 pm to 3 pm, blood pressure and hormone secretion are reduced, the body gradually produce a feeling of burnout, the skin prone to small wrinkles", also can not prove its scientific.
"8 pm to 11 pm, at this time the most prone to allergic reactions, microvascular resistance, blood pressure decline, the body prone to edema, bleeding and inflammation", there is no scientific reason.
allergies have nothing to do with time, as long as contact with allergens, skin will be allergic. in addition,
, "timetable" on the "8 a.m. to 12 a.m., the skin resistance is strongest, sebum gland secretion is also the most active, can do body hair removal, de-spot, de-smear, as well as eyebrows, eyeliner and other beauty projects" is not scientific.
hair removal, de-plaque, de-removal, etc. belong to the scope of medical beauty, need to be under the guidance of a regular hospital dermatologist, must not blindly judge themselves.
only "6 a.m. to 7 a.m.... Moisture accumulates in cells and the lymphcycle circulates slowly," as it is.
because of the low rate of cell metabolism at night sleep, blood, water circulation is slow, easy to lead to eyelid swelling.
at this time, do eye exercises or apply eye cream to enhance the circulation of the eye, there is a certain positive significance.
if it is important to discuss the biological clock of the skin, it may be more meaningful and effective to discuss changes in life cycle rhythms from infant to youth, middle age to old age, and changes in the 28-day cycle of metabolism.
only blood once or twice can measure the human biological clock is "early bird", some people are "night owls", everyone has their own set of unique biological clock.
at present, multi-national researchers are trying to develop a rapid detection of human biological clock new methods, in order to better understand the human body, health.
biological clock is the body to control the daily biological rhythm system, to help regulate about 40% of the body's genetic activity, sleep, eating, body temperature, blood pressure and other "rhythm arrangement" are related.
a common way to measure the human body's biological clock is to monitor changes in melatonin concentrations in the body, but this method requires subjects to sit in dark rooms for long periods of time and collect blood or saliva samples every hour or so.
a new issue of Scientific American, three teams are stepping up their research to develop more convenient, accurate and inexpensive testing methods, and they have chosen the same research direction, which is to assess gene activity by measuring changes in RNA in the blood, and then using machine learning algorithms to calculate which genes better reveal human rhythms.
for now, the research team has been able to take only one or two blood to measure the human biological clock. The test, developed
led by Asim Kramer of the University Hospital of Sharitai in Germany, was very close to clinical use, and the difference between the results measured using the method and the results measured with melatonin was only half an hour.
researchers say the bioclock disorder is linked to a variety of diseases, including diabetes, heart disease and depression, and finding easy ways to detect the body's biological clock will help people better understand and treat them.
, there are many more uses for testing, such as whether people stay up late the night before, with more than 90 percent accuracy.
this allows police to quickly determine whether drivers are sleeping enough when dealing with traffic accidents, or to help check whether staff in higher safety-required positions, such as pilots, are fit to work.
Source: China Medical Daily, Xinhua.com.