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January 15, 2022/EmedClub News/--Exosomes are nanoscale extracellular vesicles with a diameter between 30-150nm, which are produced by budding from the plasma membrane and endosome membranes.
important role in intercellular communication
.
In recent years, an increasing number of studies have shown that exosomes derived from immune cells display potent antitumor activity similar to their producing cells
.
On January 12, 2022, Zhang Xu's team from Jiangsu University School of Medicine published a paper on "Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy" in Science Advances, a sub-journal of Science
.
Neutrophils are the most abundant innate immune cells in the body's circulation and the first line of defense against infection
.
The research team developed a simple and efficient engineered neutrophil-derived exosomes (N-Ex) and neutrophil-derived exosome-like nanovesicles (NNV), which can be used as a safe and effective Drug delivery vehicles for tumor therapy
.
The research team isolated exosomes from peripheral blood neutrophils of healthy donors and showed that N-Ex exerts cytotoxicity on tumor cells by activating the apoptosis signaling pathway
.
The research team also developed a rapid magnetic separation method to separate exosomes from neutrophils and endow N-Ex with dual tumor-targeting capabilities (biological targeting and magnetic targeting), greatly improving its therapeutic effect
.
In addition, the research team fabricated NNV in high yield as a new delivery tool for chemotherapeutic drugs
.
Here, we demonstrate that through this strategy, superparamagnetic iron oxide nanoparticles (SPION)-modified, liposome-loaded doxorubicin (DOX)-loaded NNV achieves dual therapeutic effects (drug and NNV) in mouse tumors In the model, this almost completely eliminated tumor growth
.
▲ Schematic illustration of SPION-Ex and exosome-like NVs as novel cancer therapeutics and drug delivery nanoplatforms Overall, the study demonstrates the strong promise of engineered SPION-NNVs for targeted drug delivery and cancer therapy, and can Produced in high yields for clinical translation
.
The application of exosomes, whether exosomes or exosomes, are widely present in various liquids and carry a variety of proteins, mRNAs and other substances, which are of great significance to the diagnosis and treatment of diseases
.
In the current disease treatment, exosomes have been discovered, and then gradually attracted attention and became popular.
Exosomes are known as the next frontier field of cell therapy and have great application prospects, mainly including disease diagnosis and treatment.
Aspects, can be used as drug delivery vehicles, immune activation and immunosuppressive functions of exosomes in cancer, and as diagnostic and prognostic markers for cancer
.
With the continuous in-depth study of exosomes, it can be found that exosomes have therapeutic potential in many diseases
.
Exosomes and tumor therapy Exosomes play a dual role in tumor development
.
On the one hand, it has the ability to inhibit the growth of tumor cells; on the other hand, exosomes can promote the occurrence and development of tumors, and play an important role in the process of tumor invasion and metastasis
.
Exosomes can also transport some substances to other tissues and organs through blood and body fluids, thereby realizing tumor metastasis
.
Therefore, the study of tumor exosomes will help to reveal the molecular mechanism of tumor formation and metastasis, and provide new ideas for the treatment of tumors
.
In December 2021, Codiak bioscience, which focuses on the development of novel exosome therapies, announced that the U.
S.
FDA has approved the IND application for the company's third engineered exosome drug candidate, exoASO-STAT6, initially planned for primary liver cancer.
.
The first study of exosomes and cardiovascular disease by using exosomes as a potential therapeutic intervention in cardiovascular disease was published in 2010
.
In the early 2000s, several research groups showed that transplantation of different types of cells, mainly including mesenchymal stem cells and hematopoietic progenitor or stem cells, could be found to improve cardiac repair after myocardial infarction (MI) in experimental studies
.
The positive effects of these stem or progenitor cells have been shown to be mediated by exosomes
.
Depending on the source and content of exosomes, various cardioprotective effects can be delivered, such as improving cardiomyocyte and endothelial cell survival by regulating autophagy, activating pro-survival signaling pathways and reducing oxidative stress levels, affecting immune cell polarization and Cytokine secretion and increased activation of CD4+ T cells regulate inflammatory responses
.
Exosomes and arthritis-related diseases In the past few decades, with the in-depth study of exosomes, in addition to many studies finding that exosomes secreted by cells under pathological conditions play an important role in osteoarthritis disease, it is also found that exosomes As a good biological signaling factor, exosomes have a strong potential for repair and regeneration in cartilage
.
In addition, exosomes have also demonstrated powerful capabilities in the fields of immune system diseases, traumatic brain injury, and skin repair.
Therefore, exosomes are expected to become an emerging repair tool for "cell-free" treatment in regenerative medicine, making regeneration a possible
.
References: 1.
https://#2.
Biological Products Circle "Science Sub-Journal Cover: Zhang Xu et al.
of Jiangsu University develop engineered exosomes to treat cancer"
important role in intercellular communication
.
In recent years, an increasing number of studies have shown that exosomes derived from immune cells display potent antitumor activity similar to their producing cells
.
On January 12, 2022, Zhang Xu's team from Jiangsu University School of Medicine published a paper on "Engineered neutrophil-derived exosome-like vesicles for targeted cancer therapy" in Science Advances, a sub-journal of Science
.
Neutrophils are the most abundant innate immune cells in the body's circulation and the first line of defense against infection
.
The research team developed a simple and efficient engineered neutrophil-derived exosomes (N-Ex) and neutrophil-derived exosome-like nanovesicles (NNV), which can be used as a safe and effective Drug delivery vehicles for tumor therapy
.
The research team isolated exosomes from peripheral blood neutrophils of healthy donors and showed that N-Ex exerts cytotoxicity on tumor cells by activating the apoptosis signaling pathway
.
The research team also developed a rapid magnetic separation method to separate exosomes from neutrophils and endow N-Ex with dual tumor-targeting capabilities (biological targeting and magnetic targeting), greatly improving its therapeutic effect
.
In addition, the research team fabricated NNV in high yield as a new delivery tool for chemotherapeutic drugs
.
Here, we demonstrate that through this strategy, superparamagnetic iron oxide nanoparticles (SPION)-modified, liposome-loaded doxorubicin (DOX)-loaded NNV achieves dual therapeutic effects (drug and NNV) in mouse tumors In the model, this almost completely eliminated tumor growth
.
▲ Schematic illustration of SPION-Ex and exosome-like NVs as novel cancer therapeutics and drug delivery nanoplatforms Overall, the study demonstrates the strong promise of engineered SPION-NNVs for targeted drug delivery and cancer therapy, and can Produced in high yields for clinical translation
.
The application of exosomes, whether exosomes or exosomes, are widely present in various liquids and carry a variety of proteins, mRNAs and other substances, which are of great significance to the diagnosis and treatment of diseases
.
In the current disease treatment, exosomes have been discovered, and then gradually attracted attention and became popular.
Exosomes are known as the next frontier field of cell therapy and have great application prospects, mainly including disease diagnosis and treatment.
Aspects, can be used as drug delivery vehicles, immune activation and immunosuppressive functions of exosomes in cancer, and as diagnostic and prognostic markers for cancer
.
With the continuous in-depth study of exosomes, it can be found that exosomes have therapeutic potential in many diseases
.
Exosomes and tumor therapy Exosomes play a dual role in tumor development
.
On the one hand, it has the ability to inhibit the growth of tumor cells; on the other hand, exosomes can promote the occurrence and development of tumors, and play an important role in the process of tumor invasion and metastasis
.
Exosomes can also transport some substances to other tissues and organs through blood and body fluids, thereby realizing tumor metastasis
.
Therefore, the study of tumor exosomes will help to reveal the molecular mechanism of tumor formation and metastasis, and provide new ideas for the treatment of tumors
.
In December 2021, Codiak bioscience, which focuses on the development of novel exosome therapies, announced that the U.
S.
FDA has approved the IND application for the company's third engineered exosome drug candidate, exoASO-STAT6, initially planned for primary liver cancer.
.
The first study of exosomes and cardiovascular disease by using exosomes as a potential therapeutic intervention in cardiovascular disease was published in 2010
.
In the early 2000s, several research groups showed that transplantation of different types of cells, mainly including mesenchymal stem cells and hematopoietic progenitor or stem cells, could be found to improve cardiac repair after myocardial infarction (MI) in experimental studies
.
The positive effects of these stem or progenitor cells have been shown to be mediated by exosomes
.
Depending on the source and content of exosomes, various cardioprotective effects can be delivered, such as improving cardiomyocyte and endothelial cell survival by regulating autophagy, activating pro-survival signaling pathways and reducing oxidative stress levels, affecting immune cell polarization and Cytokine secretion and increased activation of CD4+ T cells regulate inflammatory responses
.
Exosomes and arthritis-related diseases In the past few decades, with the in-depth study of exosomes, in addition to many studies finding that exosomes secreted by cells under pathological conditions play an important role in osteoarthritis disease, it is also found that exosomes As a good biological signaling factor, exosomes have a strong potential for repair and regeneration in cartilage
.
In addition, exosomes have also demonstrated powerful capabilities in the fields of immune system diseases, traumatic brain injury, and skin repair.
Therefore, exosomes are expected to become an emerging repair tool for "cell-free" treatment in regenerative medicine, making regeneration a possible
.
References: 1.
https://#2.
Biological Products Circle "Science Sub-Journal Cover: Zhang Xu et al.
of Jiangsu University develop engineered exosomes to treat cancer"
