A major breakthrough in Alzheimer's disease! Improve brain cell mitochondrial autophagy to eliminate Alzheimer's symptoms!

study by researchers from an international team represented by the University of Copenhagen gives us a deeper understanding of Alzheimer's disease. They found that the process of cleaning brain cells in people and mice with Alzheimer's disease, known as mitochondrial autophagy, was weakened. When they improved the mitochondrial autophagy of mouse brain cells, the symptoms of Alzheimer's almost disappeared.
scientists around the world are still trying to gain a deeper understanding of Alzheimer's disease to treat and even prevent it. But no effective drugs have been approved. In the latest paper, published in Nature Neuroscience, researchers from the University of Copenhagen, the National Institutes of Health and the University of Oslo and others report on a new way to treat the disease by targeting mitochondrial autophagy.
when the cleaning system doesn't work, there's a lot of damaged mitochondrials in brain cells, which is actually very dangerous," he said. In any case, the cleaning system of brain cells in people and mice with Alzheimer's disease was significantly weakened. When we improved the function of the cleaning system, the Alzheimer's symptoms in these mice almost completely disappeared. Study author Dr. Vilhelm Bohr, a professor at the NIH Center for Healthy Aging, said.
researchers found similar cleaning systems for Alzheimer's patients, Alzheimer's-induced stem cells, and mice with Alzheimer's disease and aphids. In addition, the researchers tested active substances in animal models that targeted the cleaning process. "This reinforces our results: cleaning systems are important for human and other animal cells. We are also encouraged by our ability to improve the symptoms of Alzheimer's disease associated with memory and learning in living animals. Vilhelm Bohr said.
mitochondrials are energy plants within cells. Mitochondrial autophagy destroys damaged mitochondrials and reuses the proteins in them. Past studies have shown that mitochondrial autophagy abnormalities are associated with abnormality and low survival rates in nerve cells, but so far no studies have shown it to be associated with Alzheimer's disease.
in the brains of Alzheimer's and other dementia patients, tau and beta amyloid proteins build up excessively, leading to cell death.
new animal model species, the researchers found that when mitochondrial autophagy was enhanced, the abunding of these proteins slowed down. The researchers believe their findings suggest that the cleaning process in brain cells could be a potential target for the treatment of Alzheimer's disease and deserve further exploration. So they plan to start clinical trials in humans in the near future. (Bio Valley)