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As genetic research continues to discover gene loci or DNA regions, these specific changes will affect cancer risk.
Jin said: "A PRS that indicates the risk of a certain cancer is important, but it is not enough
Jin and his colleagues used existing data from genome-wide association studies to calculate individual PRS for 16 male cancers and 18 female cancers
To verify their CPRS, the researchers used the genotype information of 202,842 men and 239,659 women from the British Biobank, which was a collection of general population participants recruited from England, Scotland, and Wales between 2006 and 2009 Cohort, and calculated the CPRS of each individual
Participants in the UK Biobank were surveyed on various life>
In the latest follow-up conducted in 2015 or 2016, the one-fifth patients with the highest CPRS (males) were nearly twice as likely to be diagnosed with cancer (males), and (females) were 1.
Patients with poor life>
Among patients with high genetic risk, the 5-year cancer incidence rates for men and women with poor life>
The limitation of this study is that individual PRS only contains the strongest genetic risk locus, ignoring the influence of the locus with weaker effect
Journal Reference :
Meng Zhu, Tianpei Wang, Yanqian Huang, Xiaoyu Zhao, Yuqing Ding, Mengyi Zhu, Mengmeng Ji, Cheng Wang, Juncheng Dai, Rong Yin, Lin Xu, Hongxia Ma, Qingyi Wei, Guangfu Jin, Zhibin Hu, Hongbing Shen.
