A generation of superstars fell in honor of RNA pioneer Professor Christine Guthrie

"Christine Guthrie's love for the RNA field is unwavering, and in many ways she is the soul

——Hitan Madhani

Professor Christine Guthrie is a distinguished scientist in the field of pre-mRNA splicing and a giant

Christine Guthrie (Source: UCSF)

Guthrie was born in April 1945 by her mother, Irene Kampen, a single mother and a writer, and many of her characters were inspired by her daughter, such as the character in the 1961 novel Life Without George, which also inspired the hit 1960s TV series

In 1962, when Guthrie first went to the University of Michigan as an undergraduate, she also had the idea

Guthrie switched to zoology, and it was this opportunity when she attended a lecture in her senior year that sparked her interest in

After graduating in 1966, Guthrie went with her husband to Wisconsin, where he was in medical school

Guthrie's work is to study the effect

In 1970, Guthrie received his Ph.

After visiting several schools, Guthrie was hired in 1973 as the first woman (and 7th faculty member) in UCSF's Department of Biochemistry and Biophysics, where she worked until her retirement

Pre-mRNA splicing is the process

But Guthrie has spent decades using yeast to study the genes for pre-mRNA splicing, cloning and sequencing yeast snRNAs, which are essential

In later years, Guthrie also focused on splicants (a group of proteins responsible for removing introns from pre-mRNA) and how they facilitate splicing

For her outstanding contributions, Guthrie was elected a Fellow of the National Academy of Sciences in 1993 and received numerous awards

As Guthrie's student, UCSF molecular biologist Dr.

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