A drug for treating burns and scalds with silver sulfadiazine powder (SD-Ag) for the treatment of burn wounds

A drug for treating burns and scalds Silver sulfadiazine powder (SD-Ag) for the treatment of burn wounds Silver sulfadiazine powder is a sulfonamide antibacterial drug, which is clinically used to treat burns and scald wound infection.
Silver sulfadiazine powder not only controls infection, but also promotes drying, scabbing, and healing on wound surface.
The common adverse reactions of silver sulfadiazine powder are local irritation, rash, dermatitis, drug fever, muscle pain, et.
It is forbidden for those who are allergic to drug.
Silver sulfadiazine powder is N-2-pyrimidinyl-4-aminobenzenesulfonamide silver sal.
Calculated by dry product, the content of C10H9AgN4O2S shall not be less than 90.
White or off-white crystalline powder; easily deteriorated when exposed to light or hea.
Generic Name: Silver Sulfadiazine English Name: Sulfadiazine SilverCAS N.
: 22199-08-2 Approval N.
: National Pharmacopoeia H43020197 Execution Standard: Chinese Pharmacopoeia 2020 Part II [Category] Sulfonamide antibacterial drug.
【Storage】 shading, sealed and stored in a cool plac.
【Preparation】 (1) Silver sulfadiazine ointment (2) Silver sulfadiazine cream 【Storage】 Shade, airtight, and store in a cool plac.
The use method of raw material drug silver sulfadiazine powder in the treatment of pressure ulcers and bedsores [main ingredients] sulfadiazine, silver nitrat.
[Pharmacological action] Like sulfadiazine, the silver salt contained in it has astringent effect, making the wound dry, scabbed and healed earl.
This product has the effect of both sulfadiazine and silver salt, has broad-spectrum antimicrobial activity, has good antibacterial effect on gram-positive bacteria, gram-negative bacteria, yeast and other fungi, and is not affected by para-aminobenzoic aci.
antagonis.
[Pharmacokinetics] When this product is in contact with the wound exudate, it is slowly metabolized, and some drugs can be absorbed into the blood from the local are.
Generally, the absorption amount is less than 1/10 of the administered amoun.
20μg/m.
Pharmacological effects: Sulfonamide antibacterials have the effects of both sulfadiazine and silver salts, have broad-spectrum antimicrobial activity, and have good antibacterial effects on most gram-positive bacteria, gram-negative bacteria, yeast and other fung.
And it is not antagonized by p-aminobenzoic acid, and the silver salt it contains has astringent effect, which makes the wound dry, scabbed and healed earl.
Indications: This product is mainly suitable for the prevention and treatment of wound infection secondary to Ⅱ and Ⅲ degree burns, including Enterobacteriaceae, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus, Candida sp.
Caused by fungi such as bacteri.
So, what is the clinical application knowledge of silver sulfadiazine powder? Let's introduce the use and precautions of silver sulfadiazine powde.
Silver sulfadiazine is a combination of sulfadiazine and silver nitrat.
It has the astringent effect of silver and the antibacterial and anti-inflammatory effect of sulfadiazin.
It is mainly used as an external drug for the treatment of dry burn wound.
It has clinical effects on controlling, preventing and killing Pseudomonas aeruginosa, as well as promoting wound pre-combination, skin grafting and regeneratio.
In addition to the infection of dry burn wounds, silver sulfadiazine can also be used to treat dry bedsore wounds, local frostbite, MSA-infected ulcers, and chronic cheiliti.
The research progress of silver sulfadiazine is summarized as follow.
1 Application progress of silver sulfadiazine in burn wounds The purpose of treating burn wounds is to prevent infection, reduce wound exudation, and accelerate wound healin.
For a long time, silver sulfadiazine has become an important drug for wound treatment, and its excellent treatment has become a clinical consensu.

Since silver sulfadiazine was used in the treatment of burn wounds in the late 1960s, it has become a widely used topical burn medicine at home and abroad, with few side effects except one-time pai.
In the literature at home and abroad, other external medicines for burns are often compared with silver sulfadiazine, which also explains the remarkable achievements of silver sulfadiazine as a topical medicine for burns to a certain exten.
Study on the pharmacological effects of silver sulfadiazine on burn wound.
The effect of silver sulfadiazine powder Silver sulfadiazine powder is an antibacterial drug, which can clinically prevent and treat mild burns and secondary wound infection.
Silver sulfadiazine powder not only has antibacterial activity, but also has astringent effect, which can make the burn surface dry and scab, and promote wound healin.
When the silver sulfadiazine powder is in contact with the wound surface, the exudate will be slowly metabolized, and some drugs can enter the blood, and the absorption rate is not hig.
If the wound surface is extensive, the dosage needs to be increased, the absorption of the drug will increase, and the concentration in the blood will be highe.
If the tissue is necrotic, it is difficult for the drug to penetrat.
The use of silver sulfadiazine powder should be noted that silver sulfadiazine powder is a topical drug for topical treatment, applied directly to the wound of the patient, and then applied with gauz.
Silver sulfadiazine powder is used once a day in a dose not exceeding 30g per da.
The adverse reactions of silver sulfadiazine powder mainly include local irritation, dermatitis, rash, muscle pain and other allergic reaction.
After the drug is locally absorbed by the skin, it can cause thrombocytopenia, aplastic anemia, inflammation,et.
This drug is contraindicated in patients allergic to sulfonamides or silver salt.
This article introduces the function and precautions of silver sulfadiazine powde.

Silver sulfadiazine powder is a common drug used in clinical treatment of mild burns and wound infection.
It is a topical drug with good antibacterial activit.
Silver sulfadiazine powder can pass through the placenta and has teratogenic effects, so pregnant women should avoid using i.
Silver sulfadiazine powder can also pass into the fetus through breast milk and should also be avoided by breastfeeding wome.
Silver sulfadiazine powder 100g for burn skin topical method introduces a drug for burn and scald silver sulfadiazine powder (SD-Ag) in the treatment of burn wound.
It has anti-inflammatory and bactericidal effects, and persistent use for about two weeks has obvious effects on bedsore.
However, it is recommended that patients with severe bedsores should use antiviral oral medicines to prevent wound infectio.
If it is a bedsore with blisters, you should cut the blisters under the doctor's operation, and then apply some iodine and other medicines, which can promote recover.
When ulceration occurs, the ulceration surface should be cleaned in time, and then some anti-inflammatory drugs should be applied, which will prevent the infection of the woun.