Anesthetic analgesics are a very important classification in clinical drugs, narcotic drugs are drugs that can make the whole body or body local temporary, reversible loss of consciousness and pain; analgesics mainly act on the central or peripheral nervous system, selectively inhibit and relieve all kinds of pain, reduce pain and cause fear of tension and restlessness pain drugs, morphine as the representative of analgesic analgesics and aspirin as the representative of anti-inflammatory drugs, in relieving pain.
anaesthetic pain medication is mainly divided into full hemp medication, bureau hemp medication, muscle relaxants, anesthetic analgesia drugs, sedative hypnotic drugs and other five categories.
, according to the National Bureau of Statistics, the number of surgeries in China reached 50 million in 2017 and has been on the rise.
According to the latest national cancer statistics released by the National Cancer Center in January 2019, the incidence of malignant tumors in 2015 was about 3.929 million, the death rate was about 2.338 million, and the incidence of malignant tumors has been increasing at an annual rate of about 3.9% for more than a decade, and the mortality rate has been increasing by 2.5% per year.
more than half of cancer patients have varying degrees of pain, analgesics play a huge role, adding millions of new cancer patients each year.
According to the China Pharmaceutical Industry Information Center, the market for whole drugs in sample hospitals in key cities has been growing steadily from 2010 to 2016, with a compound annual growth rate of 13% and sales of sample hospitals of 1.544 billion yuan in 2016.
currently the most clinically used are intravenous whole hemp drugs, inhaled whole hemp drugs and local narcotic drugs, the most used are propofol, reliance on methane and hexafluorane.
, also known as propofol, is a short-acting intravenous anesthetic used to induce and maintain general anesthesia.
the market is mainly occupied by foreign-funded enterprises, of which the original research enterprises AstraZeneca accounted for 45%, Fessen Yuscabi accounted for 36%, local enterprises Libang Pharmaceuticals, Enhua Pharmaceuticals, Yangzijiang Pharmaceuticals, Jiuxu Pharmaceuticals, Northeast Pharmaceuticals, One Pharmaceuticals, Jiabo Pharmaceuticals, Guorui Pharmaceuticals occupied the remaining market.
2. Relying on Mimi esters its side effects are greater, but due to the cardiovascular, respiratory circulation impact is small, can be used as a substitute for propofol, the market growth is also relatively rapid, the current production enterprises include the local Enhua Pharmaceuticals, Jiuxu Pharmaceuticals, Hengrui Pharmaceuticals, foreign companies originally researched in Germany Belang, Jiangsu Enhua occupies more than 70% of the market share, Belang only about 20%.
3. Hexafluorane hexafluorane is a relatively new inhalation general anaesthetic drug, easy to use, good efficacy, good safety, small side effects, in the clinical application of more and more extensive.
the current production enterprises include local enterprises Hengrui Pharmaceuticals, One Product Pharmaceuticals, Lunanbet, foreign companies Japan Marushi Pharmaceuticals, Apovi and Bast Pharmaceuticals.
About 50% of the market, Japan's Marushi Pharmaceuticals about 30%, Bait Pharmaceuticals about 15%.
Industry Risk Factor 1. Drug Addiction Current narcotic analgesic drugs have problems of physical dependence and mental dependence due to continuous use, abuse or unreasonable use, i.e. addiction.
2007, the then Ministry of Health issued the Guidelines for the Clinical Application of Narcotic Drugs to ensure the safe and rational use of narcotic drugs.
2. The Government promulgated the Regulations on the Administration of Narcotic Drugs as early as 1987, which strictly regulate and restrict the supply and use of their production.
, the number of narcotic drug manufacturers is small, new enterprises will face a long audit time and marketing difficult position.
3. Technical barriers The safety requirements of analgesic drugs are high, drug innovation and preparation technology innovation have been the focus of research and development in this field, requiring good efficacy, high safety, small side effects and easy to use drugs.
the current anesthetic analgesic drugs are all developed by foreign enterprises, local enterprises to generic drugs, in recent years, innovative drugs mainly concentrated in biosimilar drugs and tumor-targeted drugs.
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