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While conventional therapies are often not enough to treat stubborn bowel disorders, recent studies have found that a novel, breakthrough approach can completely cure 90% of patients
.
Intestinal stool transplantation is a very effective treatment – far superior to current traditional treatments – for treating a potentially fatal infection that affects 2,500 to 3,000 people
a year in Denmark.
This is the finding
of a recent study conducted by scientists at Aarhus University and Aarhus University Hospital.
Their findings were recently published in The Lancet Gastroenterology and Liver Disease
.
In this study, researchers explored a groundbreaking fecal transplant to treat patients with C.
difficile infection, an infection common in the elderly or frail and sick
.
Simon Mark Dahl Baunwall, a PhD candidate in the Department of Clinical Medicine at Aarhus University Hospital, said the results of the study were very encouraging
.
"Our new study shows that after completing standard treatment, we can effectively cure infections through early use of fecal microbiota transplantation (FMT) to prevent recurrence
," he said.
Antibiotics are currently the standard treatment for Clostridium difficile, but the infection is tenacious and can recur
in many people.
Due to the inadequacy of
typical treatments, the infection can be fatal in some cases.
Currently, only the most difficult cases with three or more infections confirmed are eligible for FMT treatment
.
However, this study involving 42 patients shows that this new treatment can completely cure the vast majority of patients
.
"We found that after completing standard treatment, 19 of the 21 patients treated with FMT were cured, compared with only 7 of the 21 patients treated with placebo or other antibiotics
.
In other words, after treatment with FMT, the likelihood of curing the infection is three times higher than with our current standard treatment alone," explains
Simon Mark Dahl Baunwall.
FMT treatment is performed
by transferring healthy donor feces, which contain a complete gut microbiome ecosystem, to patients with disturbed intestinal flora.
In this study, the effect of this therapy was so remarkable that the project had to be stopped
for ethical reasons.
Simon Mark Dahl Baunwall said: "In rare cases, you may find that the treatment you are studying is so effective that it is morally impossible to continue
.
"
"Our study is an example of a new FMT treatment that is much better than standard antibiotic treatment, and it would be unethical to continue to do so because patients in the control group would be at risk
of not receiving FMT treatment.
"
Denmark is the most advanced country
in Europe in terms of promoting treatment to relevant patient groups.
However, a survey last year showed that only 25 percent of patients could benefit from
FMT treatment.
Across Europe, the figure is only one in
ten.
There are also many signs that FMT is not only an effective treatment for Clostridium difficile patients: the therapy is also being trialed in a wide range of other diseases where disturbances in the gut microbiota may be triggers
.
Simon Mark Dahl Baunwall said: "There is currently a lot of research going on around the world on FMT for the treatment of various diseases, with the most promising showing that FMT has a beneficial effect
on patients with inflammatory bowel disease and multidrug-resistant bacteria.
"
Faecal microbiota transplantation for first or second Clostridioides difficile infection (EarlyFMT): a randomised, double-blind, placebo-controlled trial
