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In the tug of war with the new crown virus, the new crown oral drug is the last "cake" for the normalization of the epidemic, and the new crown small molecule oral drug represented by Pfizer's Paxlovid and Merck's molnupiravir has become the next outlet of the epidemic
.
It can be seen from the U.
S.
government’s new crown drug procurement data that since the new crown oral drug was launched, the number of antibody drugs purchased by the U.
S.
government has declined, and the new crown oral drug procurement trend has increased significantly
.
According to Pfizer's 2021 performance report data released on February 8, Pfizer's revenue in 2021 will be US$81.
A recap of events surrounding Paxlovid
In November 2021, Pfizer announced that it had reached an agreement with the United Nations-backed MPP (Medicines Patents Organization) to allow other generic drugmakers to manufacture its oral Covid-19 drug Paxlovid
.
In the generic drug licensing agreement signed with MPP, China is not included in the list of generic drugs that can be sold to the market
What is Paxlovid?
Paxlovid is a combination antiviral drug consisting of two tablets
.
One of the tablets is Nirmatrelvir (150mg), which is a 3CL protease (also called main protease, Mpro) inhibitor of the new coronavirus
What other new crown oral drugs?
What other new crown oral drugs? In the last year, progress has been made in a number of different types of new crown treatment drugs, such as new crown neutralizing antibody therapy, small molecule new crown drugs,
etc.
The four blockbuster products that have received the most market attention are Pfizer (3CL protease inhibitor), Kintor Pharmaceutical (AR antagonist), Roche (RNA polymerase inhibitor), Merck (RNA polymerase inhibitor), the four major pharmaceutical companies.
In China, many domestic pharmaceutical companies have deployed a variety of oral anti-new crown drugs
.
According to the research report of Huachuang, the "Azvudine (oral)" of Real Bio is in the clinical phase III; the "VV16 (oral)" of Junshi Bio/Wangshan Wangshui/Chinese Academy of Sciences has started the clinical phase II/III Research; Oral 3CL inhibitors from companies such as Ascletis, Simcere, Zhongsheng, and Junshi are in the preclinical research stage and are expected to enter the clinic in the next 6 months
Image source: "Better than Pfizer! The first 3CL new crown specific drug to enter the clinic in China, or it may have been licensed! 》
Medicine Times will continue to pay close attention and report in a timely manner
Reference article:
Reference article:One article to understand the new crown treatment drug nematevir / ritonavir tablets (Paxlovid)
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