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[Editor's note] In the past five years, succinate dehydrogenase inhibitor (SDHI) fungicides have been growing at a rate of about 30% every year, becoming a wonderful flower in the pesticide market
.
On May 11, the editor-in-chief of "Pesticide Express" Bai Yaluo was invited to give a presentation entitled "New Product Development and Succinic Acid Degradation by Multinational Corporations" at the "3rd Pesticide Industry Economic Operation Analysis Conference and Pesticide Industry Ranking Conference".
Hydrogenase inhibitor" report
.
In the report, Editor-in-Chief Bo not only introduced the new product development of multinational companies, but also re-analyzed the succinate dehydrogenase inhibitor fungicides, and looked forward to the market prospects of these products
.
? The global pesticide market is moving forward? In 2008, the global crop pesticide market increased by 20.
35% year-on-year, setting a record for more than 10 years; however, the situation changed suddenly.
In 2009, the pesticide market turned down and fell by 7.
04%; fortunately, In 2010, the global market maintained a slight increase in stability, and has since entered an upward channel
.
As of 2014, the global crop pesticide market experienced five consecutive years of growth
.
During the 10 years from 2004 to 2014, the compound annual growth rate of the global crop pesticide market was 5.
81%
.
? The strengthening of the US dollar, the decline in agricultural product prices, and the high inventory levels, etc.
, jointly promoted the global pesticide market to stop rising and falling in 2015
.
According to the latest statistics of Phillips McDougall, the global crop pesticide market achieved sales of US$51.
210 billion in 2015, a sharp decline of 9.
6% year-on-year, creating the largest decline in more than a decade
.
The total global pesticide market is 57.
532 billion U.
S.
dollars, a year-on-year decrease of 9.
0%
.
Table 1 2004-2014 World Crop and Non-Crop Pesticide Market (US$100 million) Year (year) Crop protection year-on-year (%) Non-crop protection year-on-year (%) Total year-on-year (%) 2004 322.
04? 46.
75? 368.
79? 2005 328.
14 +1.
89 49.
05 +4.
92 377.
19 +2.
28 2006 325.
08 -0.
.
From 2000 to 2022, the company listed one new product almost every year, and clarified the peak sales and the time to achieve the target for each new product
.
The annual peak sales of its new products average more than US$400 million
.
The active ingredients of the company's 15 new and R&D pipelines will bring the company's annual peak sales of 6.
30 billion US dollars in the future
.
? Syngenta has 9 products in its R&D pipeline.
These products will be launched in 2016-2022, and their potential peak sales will exceed US$3.
6 billion
.
Among them, 4 products target field crops, and the other 5 products are used for special crops and seed treatment
.
? The products of the four target field crops are all large-scale products, with annual peak sales exceeding US$550 million
.
In particular, pydiflumetofen, the largest product among them, will have its annual peak sales exceeding 750 million U.
S.
dollars.
This is a succinate dehydrogenase inhibitor (SDHI) fungicide.
.
? Table 2? Syngenta's 9 product active ingredients in the R&D pipeline.
Product types.
Estimated peak annual sales of pydiflumetofen fungicides at the time of market.
Daejeon >750 million U.
S.
dollars for unnamed pesticides in Daejeon in 2021; Daejeon >550 million U.
S.
dollars for unnamed pesticides Herbicide, Daejeon will be more than US$600 million in 2022, an unnamed fungicide, Daejeon will be more than 6.
.
Among them, the annual peak sales of the fungicide Elatus (benzonifluconazole + azoxystrobin) will exceed US$1.
0 billion.
The company expects to achieve this goal in 2018
.
The quaternary compound herbicide Acuron (bicyclopyrone + mesotrione + atrazine + metolachlor) was launched in the United States in 2015, and achieved sales of 100 million US dollars in the first year of the market, and its annual peak sales will exceed US$500 million
.
Table 3? Syngenta's recently launched six products on the market, the effective ingredient product type annual peak sales time to achieve the target Elatus (benzodifluconazole + azoxystrobin) fungicide> 1,000 billion U.
S.
dollars in 2018 Acuron (bicyclopyrone + sulfonate) Metracone + atrazine + refined metolachlor) herbicide> 500 million US dollars? Seguris (pyrazonamid) fungicide 150 million US dollars 2018 Clariva (Pasteurella) seed treatment 2.
.
? BASF has set an annual peak sales of more than 600 million euros for fluconazole, and the annual peak sales potential of saflufenacil will exceed 200 million euros
.
? Among the three pesticides in BASF's R&D pipeline, two are authorized by Japanese companies, and one is developed by BASF itself
.
All three products have entered a higher-level research and development stage, and the company plans to launch these products in 2016/17
.
?? Table 4? BASF's research and development products, active ingredients, product types, annual peak sales of pyraclostrobin fungicides? Fluconazole fungicides> 600 million euros, saflufenacil herbicides> 200 million euros, unnamed herbicides? 3 unnamed pesticides? Cultivance genetically modified soybeans?
.
? Dow AgroScience hopes that by 2018, sales of its new products can create a $1 billion increase
.
By 2018, four new pesticides (Sulfluoxapyr, fluclopyridin, Rinskor, Inatreq) are expected to increase the company's sales by 300-400 million U.
S.
dollars; during the period, the new seed series is expected to increase by 600-700 million U.
S.
dollars Sales
.
?? Table 5? From 2018 to 2018, Dow AgroSciences new product sales increased by 1 billion U.
S.
dollars.
Active ingredient product type sales increased by 300 million to 400 million U.
S.
dollars for chlorpyridin herbicide Rinskor ( florpyrauxifen) New seed series of herbicide unnamed fungicide? An increase of US$600 million to US$700 million in total? An increase of US$1 billion.
The company pointed out that its recently launched products have a compound annual growth rate of more than 25%
.
These products include clospyridin, flufentrazone, penoxsulam, spinetoram, and sulfoxaflor
.
? Dow AgroSciences mainly uses three waves of new pesticide technologies to strongly support its future growth goals
.
? Fluoxaflor and the herbicide Enlist Duo (24-D Choline + Glyphosate) constitute the first wave of Dow Agronomy's three new pesticides
.
Fluoxaflor is a pioneer in the market, and it provides a new solution to the US$2 billion market for the prevention and control of sap-feeding pests
.
By the end of 2015, sulfoxaflor has been listed in 34 countries around the world, and its annual peak sales will exceed US$400 million
.
? The second wave of products consists of the herbicide fluclopyr and the fungicide Inatreq
.
In 2014, fluclopyridine was first registered in China, which was the first registration of the product in the world
.
Fluclopyridine has a novel mechanism of action and is regarded as a new tool for controlling stubborn broad-leaved weeds on many crops, including wheat and barley
.
Its annual peak sales are expected to exceed $400 million
.
? The addition of Inatreq, a fungicide for cereals, will make the company's fungicide product portfolio more complete
.
In the field of prevention and treatment of Septoria spp.
, Inatreq is the first compound in the industry to provide a new site of action
.
The product will be available from 2018 to 2019, and its annual peak sales are expected to exceed US$200 million
.
? The third wave of products is represented by a broad-spectrum, post-emergence herbicide Rinskor (florpyrauxifen), which will be used to control grass weeds, broad-leaved weeds and sedges in many crops, including rice
.
The product will provide a new weed control mechanism to solve the known resistance problem
.
Rinskor is expected to be listed between 2017 and 2018, and its annual peak sales will greatly exceed US$200 million
.
? DuPont? Between 2008 and 2014, the compound annual growth rate of DuPont's agricultural business, including pesticides and seeds, was as high as 10%
.
During the period, the compound annual growth rate of pesticides was 6%, and the compound annual growth rate of seeds was 11%
.
? In 2014, DuPont's sales of fungicides reached approximately US$800 million, of which picoxystrobin sales exceeded US$400 million.
The product has been sold in more than 50 countries in the world
.
Penthiozamide has been registered in more than 20 countries around the world, and its annual peak sales can reach US$100 million to US$500 million
.
The annual peak sales of the new foliar fungicide fluthiazole pyretidone can reach 100 million to 500 million U.
S.
dollars
.
? Table 6? DuPont's main fungicide product active ingredient sales picoxystrobin 2014 sales> 400 million U.
S.
dollars Pythiazamide annual peak sales of 100 million to 500 million U.
S.
dollars fluthiazole pyridoxine annual peak sales of 100 million ~$500 million Lumigen seed treatment series (picoxystrobin, penthiopyramide, fluthiazole pyridoxine) annual peak sales of more than $500 million DuPont hopes that its insecticides will achieve further growth
.
In 2014, its sales of chlorantraniliprole reached US$1.
2 billion, and its annual peak sales are expected to reach US$1.
5 billion
.
This year, the global sales of chlorantraniliprole were US$1.
480 billion, an increase of US$300 million from the US$1.
18 billion of thiamethoxam
.
At the same time, the company also sees the growth potential of cyantraniliprole, and the annual peak sales of this product will exceed 500 million US dollars
.
DuPont hopes to register its new insecticide Pyraxalt in China, South Korea and the Philippines in 2016 for the control of rice leafhoppers
.
Its annual peak sales can reach US$100 million to US$500 million
.
Table 7? Sales of active ingredients of DuPont's main insecticide products.
Chlorantraniliprole's 2014 sales were US$1.
20 billion? Annual peak sales were US$1.
5 billion and Cyantraniliprole annual peak sales> US$500 million.
Pyraxalt new insecticide , Annual peak sales of 100 million to 500 million US dollars dicloromezotiaz new insecticide is not named, new insecticide is not named, new nematicide? SDHI fungicides stand out? In recent years, multinational fungicides often lead the market.
, Becoming an important support for the company's sales growth
.
Among these fungicides, succinate dehydrogenase inhibitors are particularly praised.
These products are like a dark horse galloping in the pesticide market, adding a touch of color to the sluggish market.
.
? In 2014, the total global sales of fungicides including non-crop uses were 16.
365 billion US dollars, a year-on-year increase of 4.
4%
.
Among them, methoxy acrylate and triazole fungicides are far ahead
.
The sales of succinate dehydrogenase inhibitor fungicides were 1.
372 billion U.
S.
dollars, ranking third in the fungicides market
.
? Table 8? Global Fungicide Market Distribution in 2014 (by chemical type) Share of category sales (US$100 million) Share of category sales (US$100 million) Methoxyacrylates 22.
9% 37.
43 Morpholines 2.
7% 4.
39 Triazoles 21.
2% 34.
70 Phenylamides 2.
5% 4.
10 Succinate dehydrogenase inhibitors 8.
4% 13.
72 Other multi-action sites 2.
.
The sales of SDHI fungicides in 2014 increased by 29.
92% year-on-year, and the compound annual growth rate from 2009 to 2014 was 27.
2%, ranking first among all types of fungicides
.
? From the chart, we can also see that regardless of the methoxy acrylate or triazole fungicides, the 2014 year-on-year growth rate and the 2009-2014 compound annual growth rate are significantly inferior
.
??? Figure 1? 2014 fungicide year-on-year growth rate and 2009-2014 compound annual growth rate (%)?? Boscalid marketed in 2003 is an important milestone in the development history of SDHI fungicides, its 2005 With sales of 105 million US dollars, this type of fungicides increased by 59.
32% year-on-year
.
In recent years, SDHI fungicides have been increasing at a rate of about 30%
.
It is estimated that the sales of SDHI fungicides in 2019 will be US$2.
050 billion, and the compound annual growth rate from 2014 to 2019 will be 8.
4%
.
? Table 9? Global sales of SDHI fungicides in recent years (100 million US dollars) Time (years) The proportion of SDHI sales year-on-year to boscalid sales of boscalid 2003?? Listed? 2004 1.
18??? 2005 1.
88 +59.
32% 1.
05 55.
85% 2007?? 1.
.
As the third-generation broad-spectrum, high-activity SDHI fungicides are successively launched on the market, the sales of this type of products have shown a rapid upward trend
.
Especially since 2010, its growth rate has increased significantly
.
Therefore, it is believed that although SDHI fungicides are still a small group of fungicides, they will definitely not be in the future
.
??????????????????????????? Figure 2? The global market trend of SDHI fungicides from 2004 to 2014? ?? Development of SDHI fungicides The originator of the company is the United States Lililulu (now Kejuya), and currently there are more than 10 companies participating in the development
.
So far, the world's top six innovative pesticide companies have directly or indirectly participated in the development of SDHI fungicides, and domestic research and development institutions have also focused their attention here
.
On July 30, 2015, the technical and two preparations of flufenostamide jointly developed by China Agricultural United and Shandong Agricultural University were registered in China.
This is the first SDHI fungicide developed by a domestic enterprise and listed on the market
.
So far, 23 varieties of SDHI fungicides have been born
.
? Table 10? The 23 SDHI fungicides that are currently on the market or are about to go on the market.
The serial numbers of the English common name Chinese common name Structure type Creation company listing time Annual peak sales 1 carboxin rust thixolan? Dienamides United States Favorable way? (now Kejuya) 1969? 2 oxycarboxin 1975? 3 mepronil
.
? ?? Table 11? SDHI-type fungicides compound patent overview Generic name Patent number Application date Expiration date Patent attribution company Carboxin US3249499 1965-04-26 1985-04-26 U.
S.
Lililai Road (now Kozuya) US3393202 1965-04-26 1985-07-16 US3454391 1966-05-04 1986-07-08 Oxycarboxin US3399214 1965-11-05 1985-11-05
.
? ?? Table 12? Sales of SDHI fungicides in 2014 (US$100 million) Share of active ingredients Share of sales Active ingredients Share of sales Boscalid 28.
43% 3.
90 Chlorine 5.
47% 0.
75 Fluconazole Amide 20.
77% 2.
85 Fluopyram 4.
37% 0.
60 Bixafen 14.
58% 2.
00 Pyoxifen 3.
64% 0.
.
On May 11, the editor-in-chief of "Pesticide Express" Bai Yaluo was invited to give a presentation entitled "New Product Development and Succinic Acid Degradation by Multinational Corporations" at the "3rd Pesticide Industry Economic Operation Analysis Conference and Pesticide Industry Ranking Conference".
Hydrogenase inhibitor" report
.
In the report, Editor-in-Chief Bo not only introduced the new product development of multinational companies, but also re-analyzed the succinate dehydrogenase inhibitor fungicides, and looked forward to the market prospects of these products
.
? The global pesticide market is moving forward? In 2008, the global crop pesticide market increased by 20.
35% year-on-year, setting a record for more than 10 years; however, the situation changed suddenly.
In 2009, the pesticide market turned down and fell by 7.
04%; fortunately, In 2010, the global market maintained a slight increase in stability, and has since entered an upward channel
.
As of 2014, the global crop pesticide market experienced five consecutive years of growth
.
During the 10 years from 2004 to 2014, the compound annual growth rate of the global crop pesticide market was 5.
81%
.
? The strengthening of the US dollar, the decline in agricultural product prices, and the high inventory levels, etc.
, jointly promoted the global pesticide market to stop rising and falling in 2015
.
According to the latest statistics of Phillips McDougall, the global crop pesticide market achieved sales of US$51.
210 billion in 2015, a sharp decline of 9.
6% year-on-year, creating the largest decline in more than a decade
.
The total global pesticide market is 57.
532 billion U.
S.
dollars, a year-on-year decrease of 9.
0%
.
Table 1 2004-2014 World Crop and Non-Crop Pesticide Market (US$100 million) Year (year) Crop protection year-on-year (%) Non-crop protection year-on-year (%) Total year-on-year (%) 2004 322.
04? 46.
75? 368.
79? 2005 328.
14 +1.
89 49.
05 +4.
92 377.
19 +2.
28 2006 325.
08 -0.
.
From 2000 to 2022, the company listed one new product almost every year, and clarified the peak sales and the time to achieve the target for each new product
.
The annual peak sales of its new products average more than US$400 million
.
The active ingredients of the company's 15 new and R&D pipelines will bring the company's annual peak sales of 6.
30 billion US dollars in the future
.
? Syngenta has 9 products in its R&D pipeline.
These products will be launched in 2016-2022, and their potential peak sales will exceed US$3.
6 billion
.
Among them, 4 products target field crops, and the other 5 products are used for special crops and seed treatment
.
? The products of the four target field crops are all large-scale products, with annual peak sales exceeding US$550 million
.
In particular, pydiflumetofen, the largest product among them, will have its annual peak sales exceeding 750 million U.
S.
dollars.
This is a succinate dehydrogenase inhibitor (SDHI) fungicide.
.
? Table 2? Syngenta's 9 product active ingredients in the R&D pipeline.
Product types.
Estimated peak annual sales of pydiflumetofen fungicides at the time of market.
Daejeon >750 million U.
S.
dollars for unnamed pesticides in Daejeon in 2021; Daejeon >550 million U.
S.
dollars for unnamed pesticides Herbicide, Daejeon will be more than US$600 million in 2022, an unnamed fungicide, Daejeon will be more than 6.
.
Among them, the annual peak sales of the fungicide Elatus (benzonifluconazole + azoxystrobin) will exceed US$1.
0 billion.
The company expects to achieve this goal in 2018
.
The quaternary compound herbicide Acuron (bicyclopyrone + mesotrione + atrazine + metolachlor) was launched in the United States in 2015, and achieved sales of 100 million US dollars in the first year of the market, and its annual peak sales will exceed US$500 million
.
Table 3? Syngenta's recently launched six products on the market, the effective ingredient product type annual peak sales time to achieve the target Elatus (benzodifluconazole + azoxystrobin) fungicide> 1,000 billion U.
S.
dollars in 2018 Acuron (bicyclopyrone + sulfonate) Metracone + atrazine + refined metolachlor) herbicide> 500 million US dollars? Seguris (pyrazonamid) fungicide 150 million US dollars 2018 Clariva (Pasteurella) seed treatment 2.
.
? BASF has set an annual peak sales of more than 600 million euros for fluconazole, and the annual peak sales potential of saflufenacil will exceed 200 million euros
.
? Among the three pesticides in BASF's R&D pipeline, two are authorized by Japanese companies, and one is developed by BASF itself
.
All three products have entered a higher-level research and development stage, and the company plans to launch these products in 2016/17
.
?? Table 4? BASF's research and development products, active ingredients, product types, annual peak sales of pyraclostrobin fungicides? Fluconazole fungicides> 600 million euros, saflufenacil herbicides> 200 million euros, unnamed herbicides? 3 unnamed pesticides? Cultivance genetically modified soybeans?
.
? Dow AgroScience hopes that by 2018, sales of its new products can create a $1 billion increase
.
By 2018, four new pesticides (Sulfluoxapyr, fluclopyridin, Rinskor, Inatreq) are expected to increase the company's sales by 300-400 million U.
S.
dollars; during the period, the new seed series is expected to increase by 600-700 million U.
S.
dollars Sales
.
?? Table 5? From 2018 to 2018, Dow AgroSciences new product sales increased by 1 billion U.
S.
dollars.
Active ingredient product type sales increased by 300 million to 400 million U.
S.
dollars for chlorpyridin herbicide Rinskor ( florpyrauxifen) New seed series of herbicide unnamed fungicide? An increase of US$600 million to US$700 million in total? An increase of US$1 billion.
The company pointed out that its recently launched products have a compound annual growth rate of more than 25%
.
These products include clospyridin, flufentrazone, penoxsulam, spinetoram, and sulfoxaflor
.
? Dow AgroSciences mainly uses three waves of new pesticide technologies to strongly support its future growth goals
.
? Fluoxaflor and the herbicide Enlist Duo (24-D Choline + Glyphosate) constitute the first wave of Dow Agronomy's three new pesticides
.
Fluoxaflor is a pioneer in the market, and it provides a new solution to the US$2 billion market for the prevention and control of sap-feeding pests
.
By the end of 2015, sulfoxaflor has been listed in 34 countries around the world, and its annual peak sales will exceed US$400 million
.
? The second wave of products consists of the herbicide fluclopyr and the fungicide Inatreq
.
In 2014, fluclopyridine was first registered in China, which was the first registration of the product in the world
.
Fluclopyridine has a novel mechanism of action and is regarded as a new tool for controlling stubborn broad-leaved weeds on many crops, including wheat and barley
.
Its annual peak sales are expected to exceed $400 million
.
? The addition of Inatreq, a fungicide for cereals, will make the company's fungicide product portfolio more complete
.
In the field of prevention and treatment of Septoria spp.
, Inatreq is the first compound in the industry to provide a new site of action
.
The product will be available from 2018 to 2019, and its annual peak sales are expected to exceed US$200 million
.
? The third wave of products is represented by a broad-spectrum, post-emergence herbicide Rinskor (florpyrauxifen), which will be used to control grass weeds, broad-leaved weeds and sedges in many crops, including rice
.
The product will provide a new weed control mechanism to solve the known resistance problem
.
Rinskor is expected to be listed between 2017 and 2018, and its annual peak sales will greatly exceed US$200 million
.
? DuPont? Between 2008 and 2014, the compound annual growth rate of DuPont's agricultural business, including pesticides and seeds, was as high as 10%
.
During the period, the compound annual growth rate of pesticides was 6%, and the compound annual growth rate of seeds was 11%
.
? In 2014, DuPont's sales of fungicides reached approximately US$800 million, of which picoxystrobin sales exceeded US$400 million.
The product has been sold in more than 50 countries in the world
.
Penthiozamide has been registered in more than 20 countries around the world, and its annual peak sales can reach US$100 million to US$500 million
.
The annual peak sales of the new foliar fungicide fluthiazole pyretidone can reach 100 million to 500 million U.
S.
dollars
.
? Table 6? DuPont's main fungicide product active ingredient sales picoxystrobin 2014 sales> 400 million U.
S.
dollars Pythiazamide annual peak sales of 100 million to 500 million U.
S.
dollars fluthiazole pyridoxine annual peak sales of 100 million ~$500 million Lumigen seed treatment series (picoxystrobin, penthiopyramide, fluthiazole pyridoxine) annual peak sales of more than $500 million DuPont hopes that its insecticides will achieve further growth
.
In 2014, its sales of chlorantraniliprole reached US$1.
2 billion, and its annual peak sales are expected to reach US$1.
5 billion
.
This year, the global sales of chlorantraniliprole were US$1.
480 billion, an increase of US$300 million from the US$1.
18 billion of thiamethoxam
.
At the same time, the company also sees the growth potential of cyantraniliprole, and the annual peak sales of this product will exceed 500 million US dollars
.
DuPont hopes to register its new insecticide Pyraxalt in China, South Korea and the Philippines in 2016 for the control of rice leafhoppers
.
Its annual peak sales can reach US$100 million to US$500 million
.
Table 7? Sales of active ingredients of DuPont's main insecticide products.
Chlorantraniliprole's 2014 sales were US$1.
20 billion? Annual peak sales were US$1.
5 billion and Cyantraniliprole annual peak sales> US$500 million.
Pyraxalt new insecticide , Annual peak sales of 100 million to 500 million US dollars dicloromezotiaz new insecticide is not named, new insecticide is not named, new nematicide? SDHI fungicides stand out? In recent years, multinational fungicides often lead the market.
, Becoming an important support for the company's sales growth
.
Among these fungicides, succinate dehydrogenase inhibitors are particularly praised.
These products are like a dark horse galloping in the pesticide market, adding a touch of color to the sluggish market.
.
? In 2014, the total global sales of fungicides including non-crop uses were 16.
365 billion US dollars, a year-on-year increase of 4.
4%
.
Among them, methoxy acrylate and triazole fungicides are far ahead
.
The sales of succinate dehydrogenase inhibitor fungicides were 1.
372 billion U.
S.
dollars, ranking third in the fungicides market
.
? Table 8? Global Fungicide Market Distribution in 2014 (by chemical type) Share of category sales (US$100 million) Share of category sales (US$100 million) Methoxyacrylates 22.
9% 37.
43 Morpholines 2.
7% 4.
39 Triazoles 21.
2% 34.
70 Phenylamides 2.
5% 4.
10 Succinate dehydrogenase inhibitors 8.
4% 13.
72 Other multi-action sites 2.
.
The sales of SDHI fungicides in 2014 increased by 29.
92% year-on-year, and the compound annual growth rate from 2009 to 2014 was 27.
2%, ranking first among all types of fungicides
.
? From the chart, we can also see that regardless of the methoxy acrylate or triazole fungicides, the 2014 year-on-year growth rate and the 2009-2014 compound annual growth rate are significantly inferior
.
??? Figure 1? 2014 fungicide year-on-year growth rate and 2009-2014 compound annual growth rate (%)?? Boscalid marketed in 2003 is an important milestone in the development history of SDHI fungicides, its 2005 With sales of 105 million US dollars, this type of fungicides increased by 59.
32% year-on-year
.
In recent years, SDHI fungicides have been increasing at a rate of about 30%
.
It is estimated that the sales of SDHI fungicides in 2019 will be US$2.
050 billion, and the compound annual growth rate from 2014 to 2019 will be 8.
4%
.
? Table 9? Global sales of SDHI fungicides in recent years (100 million US dollars) Time (years) The proportion of SDHI sales year-on-year to boscalid sales of boscalid 2003?? Listed? 2004 1.
18??? 2005 1.
88 +59.
32% 1.
05 55.
85% 2007?? 1.
.
As the third-generation broad-spectrum, high-activity SDHI fungicides are successively launched on the market, the sales of this type of products have shown a rapid upward trend
.
Especially since 2010, its growth rate has increased significantly
.
Therefore, it is believed that although SDHI fungicides are still a small group of fungicides, they will definitely not be in the future
.
??????????????????????????? Figure 2? The global market trend of SDHI fungicides from 2004 to 2014? ?? Development of SDHI fungicides The originator of the company is the United States Lililulu (now Kejuya), and currently there are more than 10 companies participating in the development
.
So far, the world's top six innovative pesticide companies have directly or indirectly participated in the development of SDHI fungicides, and domestic research and development institutions have also focused their attention here
.
On July 30, 2015, the technical and two preparations of flufenostamide jointly developed by China Agricultural United and Shandong Agricultural University were registered in China.
This is the first SDHI fungicide developed by a domestic enterprise and listed on the market
.
So far, 23 varieties of SDHI fungicides have been born
.
? Table 10? The 23 SDHI fungicides that are currently on the market or are about to go on the market.
The serial numbers of the English common name Chinese common name Structure type Creation company listing time Annual peak sales 1 carboxin rust thixolan? Dienamides United States Favorable way? (now Kejuya) 1969? 2 oxycarboxin 1975? 3 mepronil
.
? ?? Table 11? SDHI-type fungicides compound patent overview Generic name Patent number Application date Expiration date Patent attribution company Carboxin US3249499 1965-04-26 1985-04-26 U.
S.
Lililai Road (now Kozuya) US3393202 1965-04-26 1985-07-16 US3454391 1966-05-04 1986-07-08 Oxycarboxin US3399214 1965-11-05 1985-11-05
.
? ?? Table 12? Sales of SDHI fungicides in 2014 (US$100 million) Share of active ingredients Share of sales Active ingredients Share of sales Boscalid 28.
43% 3.
90 Chlorine 5.
47% 0.
75 Fluconazole Amide 20.
77% 2.
85 Fluopyram 4.
37% 0.
60 Bixafen 14.
58% 2.
00 Pyoxifen 3.
64% 0.