2020 POST-ASCO: The current situation and future of glioblastoma treatment.

neurogliomas are the most common primary brain tumors in the central nervous system, more than half of which are glioblastomas. !----, so, in the field of cancer treatment concept is constantly changing today, glioblastoma treatment status and progress? Invited to the Sun Yat-sen University Affiliated Oncology Hospital Professor Mu Yongxuan to answer., Chief Physician, Chief Medical Professor, Doctor of Medicine, Doctor al-DoctorAl, Director of Neurosurgery, Department of Neurology, Sun Yat-sen University Affiliated Oncology Hospital, Chairman of the Committee of Neurocancer Experts of the Chinese Society of Clinical Oncology (CSCO), Chairman of the Committee of The Surgical Oncology Professional Committee of Guangdong Cancer Association, Standing Committee of the Chinese Anti-Cancer Association Glioma Professional Committee, China Anti-Cancer Association Deputy Head of the Brain Metastatic Tumor Seratology Group of the Professional Committee of The Chinese Society of Neuroscience, member of the Department of Neuroscience Foundation and Clinical Branch of the Chinese Medical Technology Association, member of the 3D printing technology branch of the Chinese Medical Technology Association, member of the Chinese Physicians Association's Glioma Professional Committee, member of the Brain Function Research and Transformation Professional Committee of the Chinese Research Hospital Association, and deputy director of the Professional Committee of Chest Tumor Brain Metastasis in Guangdong Province.TTF electric field therapy for glioblastoma patients to bring dawn due to glioblastoma in-immersive growth, no envelope., as a result, surgery is difficult to achieve the goal of cure.of course, after surgery, further treatments such as chemotherapy can be used, but the effects that may be limited, regardless of chemotherapy.is that part of the tumor's cells belong to the radiation, chemotherapy resistance type, and radiation dose too large may also lead to brain cell necrosis, thus affecting brain function, at the same time, the brain has a blood-brain barrier, the drug is difficult to reach the concentration of tumor cells in the brain. As a result,, the five-year survival rate of glioblastoma is now only about 5%, and very few are more than 10%., although the emerging immunology and targeted treatments are under study, the efficacy of these drugs is limited in terms of research trends, which can only prolong the survival of patients to a certain extent.new research shows that the use of TTF electric field therapy can bring a ray of life to patients with gliomas.if the patient adheres well and follows the guidelines for electro-field therapy, the patient's median survival will be more than 20 months, which is currently the ideal method for the treatment of glioma.glioblastoma surgery: Although the future of electro-field treatment may replace the status of surgical treatment, but at present, surgery is the most fundamental method.surgery can remove the tumor, reduce intracranial pressure, but also can identify pathology and molecular diagnosis, and provide some guidance and help for follow-up treatment.at this stage, the intraoperative magnetic resonance, wake-up surgery, functional area tumor and other ways, has been to maximize the help of tumor removal.at the moment, it needs to be clear exactly what should be done to remove the tumor.the idea that gliomas are malignant tumors and that removal is more or less the same, however, this idea is not correct.the degree of excision of glioma determines the patient's prognosis, therefore, in recent years, I proposed the non-functional glioma En bloc removal method, this is the core of my proposed glioma surgery "tumor-free" concept, significantly improve the survival of patients, patients get significant survival benefits, in the corresponding clinical studies, 106 patients can have a median survival of more than 20 months.therefore, for patients with glioma, should emphasize as much as possible excision, otherwise, if there is residue, radiation, chemotherapy treatment is limited, resulting in a decline in survival benefits.as a surgeon, Enbloc resection should be done as well as possible at this stage.glioblastoma treatment: Multi-tool combination is the future although in ASCO and NCCN guidelines, there are targeted drugs that can treat gliomas, such as bevalo zumas used in recurrent glioblastomas.however, because of the high heterogeneity of the tumor, the single target inhibitor is difficult to cope with, so a single target drug is difficult to fundamentally control the tumor.the treatment of glioblastoma syndacell tumors with multi-target and multi-treatment methods.in addition, clinical studies have been conducted to stimulate patients with dysphonoid glioblastoma patients using their newborn antigens to make a vaccine to stimulate patients' DC cells., although the cost of the trial is too high to be given free of charge to a limited patient population, the trend of patient benefit has been observed in the patient population in Germany and the UK.therefore, immunity therapy is considered to be a treatment for glioblastoma, including the combination of active and passive immunity, which can also be tried.there is also a new treatment, namely the electric field therapy mentioned by Fang.in 2018, the treatment has been written into the guidelines.the traditional treatment simply followed by surgical sequential synchronous chemotherapy and assisted chemotherapy, electric field therapy is now available at the end of the postoperative synchrotron chemotherapy.electric field therapy can be combined with radiotherapy, chemotherapy, and even targeted, immunotherapy, to play a 1 plus 2 effect.with electric field therapy on the market in China, prices will fall further and may benefit more patients.Nathan Source: Tumor Information, !-- End of Content Presentation -- !-- Determine If Login Ends.