2020 CCO China Oncology Conference. Huang Xiaojun: Precision treatment of leukemia - China's program, the world shared.

Leukemia is a malignant tumor that seriously endangers human health, the mortality rate is high, the treatment is difficult, the treatment cycle is long, and the precision treatment system of leukemia composed of rich leukemia treatment method combined with biomarkers brings hope to finally overcome this malignant tumor.
treatment methods are rich and diverse: including hematopoietic stem cell transplantation and cell therapy, chemotherapy, monoantimmune and targeted treatment, induced differentiation, leading the development of precision targeted therapy.
acute early childhood leukemia (APL) was once a malignant tumor with a very high fatality rate, and the application of all-trans-vitamin acid by the Shanghai team in China was a turning point in the treatment of global APL.
"Shanghai Programme", which includes a joint vitamin acid and arsenic agent, has become a pioneer and example of targeted therapy, revolutioning international hematology.
and oral arsenic therapy APL is equivalent to intravenous arsenic, forming a new model of home treatment and affecting international guidelines.
arsenic has been included in the national medical insurance list to promote the revitalization and development of Chinese medicine.
isogenetic hematopoietic stem cell transplantation is one of the most effective methods to cure leukemia and other blood diseases, due to implantation difficulties and graft anti-host disease (anti-host disease), long-term can only use human leukocyte differentiation antigen (HLA) all-in-one provider, the internationally recognized single-folding barrier (HLA non-fit/semi-conjugation) is difficult to overcome.
By clarifying a new mechanism for induced immune tolerance by granulocyte cluster stimulation factor (G-CSF), the Huang Xiaojun team at Peking University People's Hospital has stabilized the implantation of single-multiplied combined stem cells and reduced the resistance of grafts to host disease; After anti-host disease, improve the efficacy of relapse prevention and treatment after leukemia transplantation, form the internationally widely used provider selection rule, and finally form the world's first single-fold transplant system, the first time to achieve HLA non-efficacy is not related to clinical efficacy, the first time to prove that single-multiply combination transplant treatment of leukemia is better than chemotherapy, and HLA all-in transplant efficacy is the same.
The above series of work breaks through the "clinical exclusion zone" of single-fold combination transplantation, creates a new model of treatment of blood diseases - "Beijing Program", basically solves the world problem of lack of sources of hematopoietic stem cell transplantation, and leads the world into a new era of supply for all.
treatment of malignant blood diseases, bridging, sequentia hematopoietic stem cell transplantation, and application after transplantation, opened a new era of blood tumor diagnosis and treatment! In summary, there has been a breakthrough in the diagnosis and treatment of blood tumors, the Shanghai program is a pioneer in targeted treatment, and the Beijing program is a model of original technology.
to explore new therapeutic targets, conduct clinical trials of new drugs, and optimize stem cell transplantation is the mission and direction of blood oncologists in the new era.
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