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16 Recognized and Promising Longevity Supplements, see how many are familiar to you?

 Last Update: 2022-09-15
 Source: Internet
 Author: User

16 longevity supplements

→ rapamycin

Rapamycin, also known as sirolimus, is primarily used to suppress immunity, is useful

Suppresses immunity

Rapamycin has the effect of senomorphics, which is able to change the cellular aging phenotype and prevents senescent (zombie) cells from releasing inflammatory molecules

Efficacy of senomorphics,

There are two ways to intervene in aging: senolytics are mainly to work by eliminating aging cells; The function realization of senomorphics is achieved by regulating the characteristics of senescent cells and rejuvenating them

Improving cellular health has the potential to prolong healthy lifespans
Rapamycin's ability to inhibit the mTOR target has antifungal, immunosuppressive and anti-cancer properties

mTOR targets antifungal, immunosuppressive and anticancer
Rapamycin is not a complete suppression of the immune response, but to prevent immune overreaction, healthy people eat without worrying about losing immunity

mTOR is involved in many processes associated with aging, including cellular senescence, immune response, cell stem regulation, autophagy, mitochondrial function, and protein homeostasis
.

mTOR acts as a cell nutrient sensing and energy regulator, regulating cell anabolism, cell cycle progression, and cell growth
.

It can also cause the same effect as fasting and valley breaking, which increases blood sugar, but this reaction is generally mild and reversible, and can be restored
after discontinuation.
Raises blood glucose and recovers after mild and reversible discontinuation
→ Metformin
→ Metformin
Metformin is an old friend that many people are familiar with, although it is a diabetes drug, it has anti-aging, anti-tumor, cardiovascular protection effects
.
Related reading→ Why is metformin anti-aging and longevity?
Anti-aging, anti-tumor protection cardiovascular
It plays an anti-aging role through three aspects:
1.
Inhibits mitochondrial respiratory chain complex I, resulting in an increase in ampoule/ATP ratio, and then activates AMPK
.
Activate AMPK
.
Activating AMPK enables:
1.
Inhibit the downstream mTOR pathway, thereby improving nutrient perception and autophagy function
.

2.
Activate the PGC-1α signaling pathway, promote mitochondrial growth, and inhibit telomere shortening
.

3.
Transcriptional regulation through histone modification and miRNA to exert anti-aging effect
.

Extracellular, metformin is able to downregulate insulin/IGF1 signaling, which also indirectly leads to inhibition
of the mTOR signaling pathway.

2.
The inhibition of metformin on the mitochondrial respiratory chain also leads to the non-dependent anti-aging effect of AMPK, including decreased reactive oxygen species (ROS) and decreased advanced glycosylated end products (AGEs), thereby alleviating macromolecular damage
.
AMPK's non-dependent anti-aging effects Reactive Oxygen Species (ROS) Reduce Late Glycosylated End Products (AGEs) Reduces Large Molecule Damage
.
3.
By down-regulating pro-inflammatory cytokines, NF-κB signaling, activating NRF2-Gpx7 and ATM-signaling pathways, it exerts the anti-inflammatory and anti-aging effects
of non-AMPK-dependent.
Downregulates pro-inflammatory cytokines, NF-κB signaling, activation of NRF2-Gpx7, and ATM-signaling pathways
However, taking metformin has some side effects: vitamin B12 and folate deficiency, hypoglycemia, lactate buildup, gastrointestinal discomfort and so on
.
Vitamin B12 and folate deficiency, hypoglycemia, lactic acid accumulation, gastrointestinal discomfort and so on
→ spermidine
→ spermidine
Spermidine is a natural component of sperm, and our bodies (male and female) produce only one-third of the spermidine in the body, with the rest coming from the diet
.
Its food sources include: aged cheese, mushrooms, natto, green peppers, wheat germ, cauliflower, broccoli and so on
.
Aged cheese, mushrooms, natto, green peppers, wheat germ, cauliflower, broccoli
Asians consume more argenic acid from their diets, which may be related
to their long lifespan.
Long lifespan
In recent years, research on spermidine has been growing, and current studies have found that it has the following effects:

Prolong healthy lifespan;

Improve the cognitive level of the elderly;

Neuroprotective effect;

Reducing all-cause mortality;

Lowers blood pressure;

Induce autophagy, delay aging;

It can make hair grow faster and nails firmer
.

Prolong healthy lifespan;
Improve the cognitive level of the elderly;
Neuroprotective effect;
Reducing all-cause mortality;
Lowers blood pressure;
Induce autophagy, delay aging;
It can make hair grow faster and nails firmer
.
We have also written an article before, you can review the → Science, Nature endorsement: this thing is very
powerful.
→ Hydrogen (H2)
→ Hydrogen (H2)
Hydrogen is one of the oldest and most abundant elements in the universe, and hydrogen molecular medicine is an emerging discipline that was previously used to treat respiratory diseases, and now scientists are exploring its role
in the field of "cancer control.
"
Free radicals are not always bad, and sometimes important signaling molecules, but most antioxidants indiscriminately scavenge all free radicals, which can cause damage
to the body's normal cells and tissues.
Normal cells and tissues are damaged
Molecular hydrogen, on the other hand, selectively scavenges harmful reactive free radicals, as well as those oxygen substances that interfere with normal cellular function, reducing patients' levels of
oxidative stress.
Harmful reactive free radicals interfere with normal cell function with oxygen substances that reduce the patient's oxidative stress levels
In addition to lowering ROS levels and increasing coenzyme CoQ10 levels to combat aging, molecular hydrogen has been scientifically proven:
Lower ROS levels, and increase coenzyme CoQ10 levels to fight aging

Fights inflammation;

Reduce oxidative stress;

Activates the Nrf2 endogenous antioxidant pathway;

Maintain the function of mitochondria;

Cancer control;

Prevention of damage caused by chronic psychological stress;

Fights inflammation;
Reduce oxidative stress;
Activates the Nrf2 endogenous antioxidant pathway;
Maintain the function of mitochondria;
Cancer control;
Prevention of damage caused by chronic psychological stress;
Related reading→ Zhong Nanshan and other 4 academicians endorsement: it can be antioxidant, anti-inflammatory, cancer control, many people do not know .
.
.
Related reading→ Zhong Nanshan and other 4 academicians endorsement: it can be antioxidant, anti-inflammatory, cancer control, many people do not know .
.
.
→ Epitalon
→ Epitalon
Epitalon is a synthetic anti-aging peptide, produced from the amino acid chain alanine-glutamate-asparagine-glycine, which upregulates telomerase activity in the human body to help reduce the rate
of aging.
Synthetic anti-aging peptides alanine-glutamic acid-asparagine-glycine upregulate telomerase activity in the human body to help reduce the rate of aging
Telomeres are like hard hats that protect DNA, and most chromosomes in the body have telomeres at both ends; The main function of telomerase is to help maintain the length
of telomeres in the body.

There are some diseases associated with telomeres that are too short, leading to a faster rate of aging; Epitalon can be used to treat diseases that cause premature aging, such as Bloom syndrome, Werner syndrome and so on
.
Treatment of diseases that lead to premature aging
Epitalon also helps reduce the risk of diseases associated with telomerase deficiency, such as diabetes, which is suppressed
due to telomerase deficiency because of insulin secretion.
diabetes
The peptide may also have a positive effect on heart health and may help prevent heart disease; Scientists are studying its potential
in treating tumors.
Prevention of heart disease
→ nicotinamide adenine dinucleotide (NAD+)
→ nicotinamide adenine dinucleotide (NAD+)
NAD+ is the body's energy currency, it can be said that without it, the body can not last more than 30 seconds, the body's more than 500 physiological processes need NAD+ to function
.
As we age, NAD+ declines, our energy levels decline, and our bodily functions decline, which is the main principle
of cellular aging.
As we age, NAD+ decreases cellular senescence
With the decrease of NAD+ in the body, aging is accelerated, inflammation increases, and various diseases appear
.
The decrease in NAD+ will accelerate aging, increase inflammation, and various diseases will appear
There are three main ways to increase NAD+ levels and delay aging: supplementation with NAD+ precursors, activation of NAD+ biosynthetase, and inhibition of NAD+ degradation
.
Supplementation of NAD+ precursors, activation of NAD+ biosynthetase, and inhibition of NAD+ degradation
.
Vitamin B3 is recognized as the safest and most efficient precursor to NAD+, of course, NR and NMN can also, but the clinical safety of humans has not been verified
.
Vitamin B3NAD + NRNMN
In addition to eating supplements, through diet and lifestyle changes, it is also possible to increase NAD+ levels, eat more foods containing NAD+ precursors, avoid high-sugar diets, reduce stress, improve sleep quality, etc
.
NAD+ Eat more foods containing NAD+ precursors, avoid a high-sugar diet, reduce stress, and improve sleep quality
→ISRIB
→ISRIB
The combined stress response (ISR) is usually responsible for detecting problems with protein production in cells, and if abnormalities are found, isarr can respond by inhibiting cellular protein synthesis mechanisms; ISRIB, on the other hand, stands for an inhibitor
of ISR.
The combined stress response (ISR) ISRIB stands for an inhibitor of ISR
Protein production in the body's cells is gradually damaged with aging, a process that is due to a chronic inflammatory process that occurs in the body that gradually erodes the cells and eventually leads to the extensive activation
of the comprehensive stress response (ISR).
Extensive activation of the chronic inflammatory process Comprehensive Stress Response (ISR).
ISRIB may have a wide range of effects on neurological disorders, and it can improve or even reverse neurological disorders
such as Alzheimer's disease, Parkinson's disease, Down syndrome, amyotrophic lateral sclerosis (ALS), and age-related cognitive decline.
Neurological diseases Such as cognitive decline
A 2013 rodent study found that it significantly enhanced memory and restored memories in older mice with non-traumatic brain injury
.
Significantly enhanced memory recovery in older non-traumatic brain injury mice
Cutting-edge research in 2020 found that ISRIB can reverse age-related memory decline in
older mice.
ISRIB can reverse age-related memory decline in
older mice.
It has not been observed that ISRIB can cause serious side effects, and perhaps in the near future, ISRIB can become a magical and powerful anti-aging drug
.
→ Astaxanthin
→ Astaxanthin
Affectionately known as "nature's sunscreen," a compound that gives the flesh of krill and salmon a red color, as a supplement, it is a potent antioxidant that protects the brain, nervous system, heart, and mitochondria
.
Astaxanthin "Nature's Sunscreen" antioxidant that protects the brain, nervous system, heart and mitochondria
Astaxanthin has systemic effects, from improving skin and protecting against ultraviolet rays, to scavenging free radicals to reducing inflammation, to enhancing brain function
.
Improves skin and protects against UV rays to scavenge free radicals to reduce inflammation and enhance brain function
Astaxanthin has a strong antioxidant power at the same time, but also has the advantage of systematic anti-aging
.
Powerful antioxidant capacity systematizing anti-aging

Improve the synthesis rate of antioxidant enzymes in the human body to achieve endogenous anti-aging;

Scavenging free radicals represented by monolinear oxygen in the human body;

Promotes the synthesis of elastin and collagen;

Induce autophagy, delay aging;

Improve immunity;

Improve the synthesis rate of antioxidant enzymes in the human body to achieve endogenous anti-aging;
Scavenging free radicals represented by monolinear oxygen in the human body;
Promotes the synthesis of elastin and collagen;
Induce autophagy, delay aging;
Improve immunity;
If you want to fight oxidation, especially against photoaging, you must try supplementing with astaxanthin and omega-3
.
→ ketones
→ ketones
The main reasons why the ketogenic diet is popular include losing weight and making the mind clear
.
When the body begins to burn body fat, it produces ketones that provide clean energy to the brain and boost the brain's performance
.
Ketone bodies have anti-aging effects, and studies have found that BHB (β-hydroxybutyric acid) can promote cell division, prevent cell aging, and keep blood vessels and brains young
.
BHB (β-hydroxybutyric acid) promotes cell division, prevents cellular aging and keeps blood vessels and brain young
The body can produce ketone bodies by avoiding carbohydrates, or it can take exogenous ketone supplements to speed up this process and reduce the pain of the transition period, known as the "ketone flu.
"
Taking exogenous keto supplements to speed up this process
A ketogenic diet or taking exogenous ketone supplements can slow down aging, improve cognitive performance, and help avoid neurodegenerative diseases such as Alzheimer's disease
.
It can slow down aging and improve cognitive ability to avoid neurodegenerative diseases such as Alzheimer's disease
→ dasatinib
→ dasatinib
As we age, some of our cells will escape the cleanup of the immune system, and these "surviving" cells cannot play their original role, but at the same time they are still consuming energy
.
Such "only eat and do not work" cells, also known as "zombie cells", or senescent cells, will accumulate with age, so that the efficiency of the body's operation is reduced
.
"Zombie cells" Senescent cells make the body run less efficiently
Fasting, exercise, and other healthy lifestyles trigger autophagy and clean up zombie cells
.
Dasatinib is a chemotherapy drug used to treat leukemia, which can also effectively remove aging fat cells and reduce the secretion
of pro-inflammatory cytokines in the body's adipose tissue.
Dasatinib effectively removes senescent fat cells
It was the first Senolytics drug to be discovered, a drug capable of temporarily disabling the SCAP (anti-apoptotic pathway) by interfering with the senescent cell signaling pathway, thereby selectively removing senescent cells
.
Senolytics drugs
Substances that can remove senescent cells, such as PCC1 of the Chinese Academy of Sciences, and other components
such as quercetin.
→ cannabinoids
→ cannabinoids
The active compounds of cannabis, collectively known as cannabinoids, are a group of terpenol compounds, the most famous of which are tetrahydrocannabinol (THC) and cannabidiol (CBD
).
Cannabinoids (cannabinoids) Tetrahydrocannabinol (THC) Cannabidiol (CBD)
THC is a regulated First Class of Psychotropic Substances
in China.
CBD can fight free radicals in skin cells, play an antioxidant, anti-aging effect, often added to skin care products, but also often used to relieve chronic pain, the effect is very good
.
Antioxidant, anti-aging
→ rosewood
→ rosewood
Resveratrol is no stranger to everyone, and Pterostilbene knows less, it is a methylated form
of resveratrol.
Pterostilbene is more bioavailable than resveratrol and is currently the best natural plant anti-aging hormone found:
The best natural plant anti-aging hormones:

Strong free radical scavengers;

Enhance endogenous antioxidants;

Activate sirtuins;

Activates AMP kinase;

simulated calorie restriction (luring your body into cell regeneration, which normally occurs only when starving);

Enhance autophagy;

Enhance DNA repair mechanisms;

Strong free radical scavengers;
Enhance endogenous antioxidants;
Activate sirtuins;
Activates AMP kinase;
simulated calorie restriction (luring your body into cell regeneration, which normally occurs only when starving);
Enhance autophagy;
Enhance DNA repair mechanisms;
At present, it is very popular NAD+ supplement NMN, often used in combination with pterostilbene, two anti-aging antioxidant circles of the "shoulder handle" strong combination, the effect is doubled!
NAD+
→ fullerene (C-60)
→ fullerene (C-60)
Fullerene is particularly famous in the skin care industry, it is very easy to react with free radicals, has a strong free radical absorption capacity, known as "free radical absorption sponge"
.
It reacts easily with free radicals
In one study, it also showed a powerful lifespan-prolonging effect, extending the lifespan of rats by 90%; Other mouse studies have shown a 5 to 14 percent
increase in lifespan.
Rats' lifespan increased by 90% to increase life by 5% to 14%
It works in two ways: removing metabolic waste, and neutralizing free radicals, and its other benefits include:
Removes metabolic waste, and neutralizes free radicals

Kills microorganisms;

Protection of nerves;

Prevents skin damage;

Kills microorganisms;
Protection of nerves;
Prevents skin damage;
→ curcumin
→ curcumin
Turmeric is a very Indian-inspired ingredient, and curcumin is the most studied active ingredient in turmeric, with strong anti-inflammatory and antioxidant effects
.
Studies have shown that curcumin can activate sirtuins (deacetylase), and AMPK (AMP-activated protein kinases), which help delay cellular aging and prolong lifespan
.
⑳
Activates sirtuins (deacetylatases), and AMPK (AMP-activated protein kinases)
In addition, curcumin has been shown to fight cell damage and significantly extend the lifespan of fruit flies, roundworms and mice; It can also delay the occurrence of age-related diseases and alleviate the symptoms of age-related diseases
.
Fighting cell damage significantly prolongs the lifespan of fruit flies, roundworms and mice delays the occurrence of age-related diseases and alleviates the symptoms of age-related diseases
→ Rhodiola Rosea
→ Rhodiola Rosea
Turmeric is India's anti-aging boss, while Chinese, Russians, and Navia rely on Rhodiola Rosea, a rare medicinal plant
of Rhodiola rosea.
Some studies of athletes and astronauts have shown that Rhodiola can reduce and treat disease and improve overall health, and this effect
has also been observed in healthy people.
Alleviating and treating disease improves overall health
Rhodiola's longevity effect is worth affirming, and it has many other effects:

Anti-aging;

Anti-inflammatory;

Anti-stress;

Antioxidants;

Antiviral substances;

Anti-cancer;

Improve immunity;

Enhanced NAD+ repair;

Improves adaptation
to hypoxia and angiogenesis.

Anti-aging;
Anti-inflammatory;
Anti-stress;
Antioxidants;
Antiviral substances;
Anti-cancer;
Improve immunity;
Enhanced NAD+ repair;
NAD+
Improves adaptation
to hypoxia and angiogenesis.
These food ingredients, you can try slowly, there is no need to try them all, and some ingredients overdose has certain side effects, please adjust according to the body's feedback
.
Key Skinny Dragon said
Premature aging has been classified as a disease
.
More and more scientists are engaged in the study of anti-aging, hoping to find more useful substances, prolong life and improve the quality of life
.
However, it is worth reminding that if you eat and drink every day, eat sugar, eat a lot of carbs, smoke, stress, stay up late, and sleep badly
.
Eat a lot of sugar and eat a lot of carbs
It is impossible
for you to have these bad habits, but what artifacts you rely on to make you immortal.
Most of the time, you don't need a price-added lab to slow down aging, and it's recommended to start with a
simple diet.
1.
Usually pay attention not to eat too much, through fasting, exercise or low-carbon ketogenic diet, naturally increase the level
of ketone.
2.
Use NAD+ precursors to replenish energy for cells and fight aging
.
NAD+
3.
Usually pay attention to eating more foods with high nutrient density:
For example, eat some salmon supplements ofomg-3, krill to obtain astaxanthin, you can also ingest some foods rich in curcumin, eat animal offal, egg yolk and other foods
with high nutrient density.
Do you have a unique anti-aging secret? Welcome to share the discussion
in the comments section.
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