15 billion ADR market local pharmaceutical companies accelerate import substitution

According to data from the national health and Health Commission, the number of new born in 2016 reached 17.86 million, an increase of 7.92% over the previous year, forming a small peak According to a survey data, there are about 90 million women in line with the "two child" policy in China Under the risk of old age pregnancy and childbirth, 28% of them still have the desire to have children The huge market increase of domestic assisted reproductive drugs has attracted the attention of domestic and foreign manufacturers The medical research shows that follicular dysplasia syndrome caused by endocrine dysfunction accounts for 48.42% of all the causes of infertility, ranking first in the causes of female infertility In clinical treatment, in addition to the reasonable adjustment of menstrual period and the treatment of causes, it is necessary to choose an ideal ovulation promoting program to promote the development and maturity of follicles so as to achieve the purpose of pregnancy The advancement of modern medical drug research has solved some problems and promoted the development of sex hormone drug market After the new policy of national fertility policy was launched, the market of sex hormone drugs moved, and the market of infertility treatment and IVF technology attracted more and more attention According to the data of mienei.com, in 2017, the amount of female hormone use in public hospitals in key cities reached 1.88 billion yuan, an increase rate of 5.09% over the previous year It is estimated that the market scale of assisted reproductive drugs in China has exceeded 15 billion yuan The market of clinical female hormone consists of four parts, among which gonadotropin, progesterone, estrogen, contraceptive and androgen account for 60.58%, 21.91%, 6.52% and 10.99%, respectively Domestic enterprises are trying to capture the high-end market At present, in the end market of assisted reproduction and sex hormone, bioengineering drugs have been replacing small molecular drugs Recombinant human follicle stimulating hormone, recombinant follicle stimulating hormone β, recombinant human chorionic gonadotropin and human luteinizing hormone α gradually expanded In the market structure of assisted reproduction terminal, small molecule drugs are still the basis of assisted reproduction drugs On February 2, 2018, Zhengda Tianqing's ganirik acetate injection was successfully launched, breaking the market monopoly situation of mosadong, improving the medication pattern of GnRH antagonists for ovulation induction and control of in vitro infants, and forming the full potential of cetrik, ganirik and GnRH agonist leuprorelin In general, the market of assisted reproductive drugs is basically oligarchic, most of which are controlled by foreign manufacturers Merck xuelanuo, Merck Sadong and Huiling, while domestic Lizhu group, Kinsey pharmaceutical and other industries aim at import substitution In addition, domestic hormone manufacturers such as Zhejiang Xianju, Shenzhen Hanyu, Zhejiang Aisheng, Nanjing Xinbai and Yantai Dongcheng Pharmaceutical Co., Ltd are also growing rapidly, which will open a breakthrough in the consistency evaluation of generic drugs, so as to occupy the high-end market of assisted reproductive drugs and sex hormones In the past five years, the market of gonadotropins in the public hospitals of key cities in China has doubled Gonadotropins are the first category in the market According to the data of mienei.com, in 2017, the amount of gonadotropin drugs used in public hospitals in key cities in China was 1.154 billion yuan, with a small increase under the influence of the stock market in the previous year Gonadotropins are glycoprotein hormones that regulate the development of gonads and promote the generation and secretion of sex hormones Luteinizing hormone and follicle stimulating hormone work together to stimulate the development of reproductive cells and the generation of sex hormones in ovaries or testes The top 10 varieties of gonadotropins in public hospitals of key cities in China are ranked as follows according to the terminal purchase amount: recombinant human follicle stimulating hormone, triptorelin, urofollicle stimulating hormone, urogonadotropin, recombinant follicle stimulating hormone β, cetrix, oxytocin, carbetoxine, recombinant human chorionic gonadotropin and human luteinizing hormone α The characteristics of clinical drug use are: high proportion of imported drugs, more biological products, more self paid drugs Domestic recombinant human follicle stimulating hormone is mainly used in the treatment of infertility, anovulation and polycystic ovary syndrome The original imported drug is "gonaphene", a brand drug of German Merck xuelanuo In 2015, the former CFDA approved the recombinant human follicle stimulating hormone for injection developed by Jinsai pharmaceutical, a subsidiary of Changchun hi tech, thus breaking the situation that imported drugs dominate the world In 2017, the amount of recombinant human follicle stimulating hormone used in public hospitals in key cities in China was 358 million yuan, of which the amount of "gonaphene" used by Merck xuelanuo was 345 million yuan, down 4.71% year on year The amount of recombinant human follicle stimulating hormone used in public hospitals in key cities was 12.57 million yuan, an increase of 16.44% over the previous year With the advancement of domestic drugs of Changchun Kinsey, it will gradually replace imported drugs Progesterone is the first of the three sex hormones: progesterone, estrogen and androgen According to minenet data, in 2017, the amount of progesterone used in public hospitals in key cities in China was 417 million yuan, an increase of 1.61% over the previous year Among them, the top 5 varieties are progesterone, didroxyprogesterone, medroxyprogesterone, and allylestradiol Progesterone is the first drug in the market Progesterone is a kind of progesterone which has been used for many years Progesterone is a hormone to protect the female endometrium, which can provide support and guarantee the early growth and development of fetus It plays an important role in promoting the development and maturity of the second sex sign in cooperation with estrogen According to minenet data, in 2017, the amount of progesterone used in public hospitals in key cities in China was 216 million yuan, an increase of 5.57% over the previous year The top 5 manufacturers are Merck xuelanuo, Zhejiang Xianju, faxing, Zhejiang Aisheng, Zhejiang Xinchang and Zhejiang Xinchang, accounting for 61.71%, 16.90%, 11.40%, 6.24% and 2.02%, respectively Progesterone dosage form was more In clinical samples, progesterone gel accounted for 62.22%, capsule 31.64%, injection 6.12% and suppository 0.02% Progesterone accounts for 50% of the drugstore's progesterone retail market According to the data of mienei.com, in 2016, the terminal sales of progesterone in retail pharmacies in key cities in China was 42.3 million yuan, an increase of 80.73% over the previous year It is a drug with high-speed growth in the retail market of assisted reproductive drugs in China, accounting for 50% of the retail market of progesterone in pharmacies The top 5 manufacturers of progesterone in the drugstore retail market are Merck xuelanuo (34.24%), Zhejiang Aisheng (26.25%), Zhejiang Xianju (21.99%), faxing (12.84%) and Zhejiang Xinchang Pharmaceutical (4.16%) In the retail market, progesterone capsules accounted for 65.34%, gel 34.23%, injection 0.43%, and estrogen 3 The market for estrogen drugs increased steadily According to the data from internal network, the amount of estrogen used in city hospitals in 2017 was 124 million yuan, up 9.37% over the previous year In 2017, the amount of estrogen used in public hospitals in key cities in China was 140 million yuan, an increase of 0.33% over the previous year The top 5 varieties are estradiol, estradiol didroxyprogesterone, ethinylestradiol and cyproterone, tibolone and estradiol and cyproterone valerate At present, most of the commonly used estrogen drugs are synthetic derivatives of estradiol, such as estradiol benzoate, estradiol valerate, ethinylestradiol, ethinylestradiol, marestrone and so on