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Why do we feel "full"? Eating changes the brain's astrocytes.
Time of Update: 2020-07-21
neural circuits in the human brain that control hunger and satiety can alter the connections between these feelings, thereby adjusting eating behavior and maintaining a balance between food intake and calorie consumption.
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Nature: "Brain-Spleen Axis", opens up new directions for neuroimmunology.
Time of Update: 2020-07-21
the original title "Qihai research group published a cooperative article in nature to report the new mechanism of brain spleen nerve loop control vaccine induced immune response".
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Yu Xiang's team reveals the mechanisms that DHA promotes neurodevelopment in the brain.
Time of Update: 2020-07-21
it was found that the development of dendritic spines and functional synapses could be regulated by non esterified DHA (free DHA) in vivo through rxra dependent signal pathway.
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Nat Commu . . . The Liu China/Liu Jingyu team has made significant progress in the field of sodium channels and pain.
Time of Update: 2020-07-21
recently, Professor Liu Zhonghua of Hunan Normal University and Professor Liu Jingyu of Huazhong University of science and technology / Institute of neuroscience, Chinese Academy of Sciences, published the latest research results entitled: spider venom derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels online in nature communications.
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Nature back-to-back: is it subversion or integration? A new breakthrough has been made in the field of thermothemes regulation nerves.
Time of Update: 2020-07-21
chronic activation of qrfp expressing neurons (hereinafter referred to as Q neurons) in the hypothalamus by researchers through chemical genetics technology led to the loss of activity of animals, and the body temperature dropped to about 23 – 24 ° C for up to 48 hours, showing a similar hibernation like behavior.
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The Latest: The most detailed synaptic map record - the change of synapse from birth to aging.
Time of Update: 2020-07-21
according to the molecular and morphological characteristics of synapses, the researchers further divided them into 37 subtypes, and found several characteristics: first, the molecular composition of synapses is changing throughout the life cycle, not limited to lsa-i stage; second, all brain area synaptic subtypes show rapid initial growth to peak in the first three weeks after birth, and then the diversity of synapses has always been It declined until 3 months old, and then kept dynamic balance.
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Nature: Does circadian rhythm cause clinical failure of neuroprotective drugs?
Time of Update: 2020-07-21
the researchers found that 100% oxygen could significantly reduce cerebral infarction in stroke rats during the daytime (inactive period of rats, i.e., zt3-zt9 time period), while 100% oxygen treatment at night (active period of rats, namely zt15-zt21 period) had no effect.
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Mother's Day Special: Mom loves your nerve mechanism.
Time of Update: 2020-07-21
subsequently, Professor Lin Dayu of New York University School of medicine further found that chronic inhibition of the expression of ESR1 neurons in MPOA brain area reduced the number of times that female rats retrieved mice, which inhibited maternal behavior; light activated ESR1 expressing neurons promoted the behavior of female rats to retrieve their offspring.
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Develop more effective diet pills! Shanghai University of Science and Technology co-research results on the latest "Science"
Time of Update: 2020-07-21
} the structure of the complex of MC4R and shu9119 (photo source: reference [1]) indicates that this is the first time to observe the binding mode of functional calcium ion with G protein coupled receptor.
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Cells that become "neurokillers" may be a new target for treating neurodegenerative diseases.
Time of Update: 2020-07-21
recently, a research team from the New York stem cell foundation (nyscf) published a research paper in neuron, a well-known academic journal of neuroscience, for the first time confirmed in human astrocytes that these friendly neuronal supporters can turn into the killers of toxic neurons in case of disease.
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JBC . . . The Li Dan team at Shanghai Jiaotong University has revealed the molecular mechanism of the disease-causing amyloid aggregation of alpha-syn and Tau of Alzheimer's disease.
Time of Update: 2020-07-21
Amyloid aggregation of proteins is an important pathological feature of many neurodegenerative diseases [1], such as amyloid plaques formed by a β protein in Alzheimer's disease (AD), and neurofibrillary tangles formed by tau protein in AD and other tau protein lesions [2, 3] In Parkinson's disease (PD) and other synuclein lesions, the formation of Lewy body aggregation of α - synuclein (α - SYN) proteins and so on [4,5].
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Cell Reports . . . A collaborative study by Tang Wei/King Nai-ho-King reveals the mechanism by which genetic mutations cause autism.
Time of Update: 2020-07-21
on April 21, 2020, Tang Ke, School of life sciences, Guangzhou University, Jing Naihe, Center for excellence and innovation in molecular and cell science, Chinese Academy of Sciences, and he Shuijin, School of life science and technology, Shanghai University of science and technology, jointly cooperated in cell The latest research results published online in Reports Magazine: "balance of empirical / occupational neural differentiation in neurodevelopmental disorders with an Nr2f1 point mutation".
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Nat Neurosci . . . Light affects emotions: Xue Tian/Zhao Huan's team reports on the "light-emotional" neural loop of circadian rhythm gating.
Time of Update: 2020-07-21
this study is the first time to elaborate the loop basis and rhythm gating mechanism of nocturnal light induced negative emotions.
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Neuron. Qiu Xufeng and others prove that TMIE protein is a necessary component of the mechanical electroduction channel of cochlear hair cells.
Time of Update: 2020-07-21
in conclusion, as a regulatory subunit of met channel, the N-terminal of tmie is involved in mechanical gating, and the C-terminal binds to phospholipids such as TMC1 / 2 protein and PIP2 and directly affects the characteristics of met channel.
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Cell . . . Discover new "thin" gene: ALK regulates sympathetic nerves to resist weight gain.
Time of Update: 2020-07-21
genetic and mechanism experiments show that ALK is a sympathetic regulator, which controls energy consumption by affecting lipolysis of adipose tissue, and its mutation can resist weight gain.
Through detailed genetic and mechanism experiments, it is proved that ALK regulates energy consumption through sympathetic control of adipose tissue lipolysis.
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Why is it easy for fat people to "eat more and stare"? The Wang Liming/Huang Rui collaboration reveals the neural mechanisms in which a high-fat diet promotes foraging behavior.
Time of Update: 2020-07-21
later studies also demonstrated this - the researchers found that under high-fat diet, the sensitivity of specific akhr neurons in the brain of Drosophila melanogaster to the starvation signal AKH was greatly increased, and the response of calcium signal was significantly improved, resulting in a stronger foraging behavior output.
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Nature Sub-Journal: Reveals the neural mechanisms that run faster and farther away.
Time of Update: 2020-07-21
in addition, immunofluorescence assay showed that the number of glutamatergic neurons did not change after training, which indicated that there was a conversion from cholinergic to GABAergic in CPPN.
They found that during exercise, cholinergic neurotransmitter conversion from cholinergic to GABA occurs in the brain CPPN, which promotes the ability of motor learning.
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Cell Stem Cell . . . Liang Qi and so on reveal the lipid metabolism to regulate the activity of nerve stem progenitor cells and learn memory.
Time of Update: 2020-07-21
at the same time, they found that the mutation of fatty acid synthase, a key enzyme of de novo lipogenesis, impaired the proliferation of NSPC by inducing lipid accumulation and endoplasmic reticulum stress in mice and human NSPC, resulting in decreased Ahn level and neurogenesis dependent memory impairment in hippocampus.
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Brushyour phone before bed is prone to depression? Xue Tian/Zhao Huan reveals the nerve mechanism of night-time blue light "de-depression".
Time of Update: 2020-07-21
this suggests that the iprgc → dphb → NAC pathway preferentially transmits light signals at night, thus mediating LAN induced depression like behavior.
this suggests that the iprgc → dphb → NAC pathway preferentially transmits light signals at night, thus mediating LAN induced depression like behavior.
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Neuron. "Decision Tree" at the neurotransmitter release site
Time of Update: 2020-07-21
KAESER research team of Harvard Medical School published the article synapse and active zone assembly in the absense of presynaptic Ca2 + channels and Ca2 in the journal Neuron+ The active region is more like a social platform, which determines the location and functional characteristics of synaptic connections, and calcium channels are just VIP users of the platform.
