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Molecular findings show the prospect of psoriasis gene therapy
Time of Update: 2021-02-12
Dr Kanhere explains how this finding works: in some diseases, cells lose the ability to differentiate and multiply more rapidly.
This of psoriasis, which is caused by the overbreeding of skin cells.
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Dementia: New culprits and potential treatment targets
Time of Update: 2021-02-12
“ When we see blood vessels leaking, independent of tau and not dependent on amyloid proteins, when people have cognitive impairment at mild levels, this suggests that it may be a completely independent process or a very early process," said senior author Berislav Zlokovic, director of the Zilkha Institute of Neurogenetics at the University of Southern California's Keck School of Medicine.
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Chinese and American medical experts have joined hands to make new advances in 3D bioprinting
Time of Update: 2021-02-12
The study confirms that 3D bioprinting can quickly, accurately and personalizedly construct complex cavity tissues such as blood vessels and urethra containing different functional cells with clear tissue structure through a new design system.
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The study found new breast cancer proteins
Time of Update: 2021-02-12
Professor Matt Smalley, from cardiff University's European Cancer Stem Cell Research Institute, said of the findings: "In order to achieve better outcomes for people facing the disease, we need to better understand how it develops so that we can improve treatments." We wanted to know what drives an aggressive form of breast cancer called triple negative, which is resistant to hormone therapy and occurs in about 15% of cases.
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Prevent gonorrhea with meningitis B vaccine?! GlaxoSmithKline is considering doing so!
Time of Update: 2021-02-12
For the study, researchers analyzed large-scale MeNZB vaccination data and found that the vaccine was 31 percent effective at preventing gonorrhea infections.
GSK spokesman said the company is weighing whether the vaccine Bexsero can prevent gonorrhea and is working with regulators and researchers to assess what more needs to be done to prevent gonorrhea.
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AbbVie has teamed up with Rubin, India, for $1 billion to develop the first MALT-1 inhibitor to treat a series of blood systems:
Time of Update: 2021-02-12
according to a statement released, Rubin has granted AbbVie exclusive rights to the development and commercialization of Rubin's first-in-class MALT1 (mucosal-related lymphoma congenital protein 1) inhibitor project.
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The first new drug, KPI-121, which temporarily relieves symptoms and signs of dry eye disease, including flares, is under review in the United States
Time of Update: 2021-02-12
If approved, KPI-121 (0.25%) is expected to be the first product to temporarily relieve symptoms and signs of dry eye disease, including the treatment of dry eye flares.
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It reveals the toxic mechanism of chromycin and develops a promising class of anti-tuberculosis drugs
Time of Update: 2021-02-12
a new study, researchers from research institutions such as the University of Oxford in the United Kingdom studied the toxicity formation mechanism of lysycin and found that it acted on the gene DPAGT1, which produces an enzyme involved in the biosynthetic synthesis of glycogen.
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The new study identifies 35 genes associated with the risk of chronic kidney disease
Time of Update: 2021-02-12
Researchers have identified 35 genes linked to the risk of chronic kidney disease, and based on this result, better diagnoses and treatments are expected to be developed in the future, according to a new study by the University of Manchester.
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The new stem cell therapy is expected to cure leukemia completely
Time of Update: 2021-02-12
Stem cell transplants can be effective in treating leukemia, but in many cases, immune cells from the receptor attack the healthy tissue of the recipient's body, with lethal consequences, and in a recent study published in the international journal Science Translational Medicine, scientists from the University of Zurich and others identified a special molecule that plays a key role in the process, blocking the molecule's function and significantly improving the prognostic status of patients receiving stem cell transplant therapy.
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Blue light may help reduce blood pressure and the risk of cardiovascular disease
Time of Update: 2021-02-12
In a recent study published in the international journal European Journal of Prevention Cardiology, scientists from institutions such as the University of Surrey found that exposure to blue light may
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CRISPR genome editing is expected to be used in plastic surgery
Time of Update: 2021-02-12
According to a Paper entitled "CRISPR Craft: DNA Editing the Reconstructive Ladder", published in November 2018 in the official journal of the American Society of Plastic Surgery, the genome editing technique promises potential progress in everything from preventing craniofacial malformations to therapeutic skin transplants to new non-exclusion transplants.
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The research and development of PARP inhibitors for the treatment of BRCA1/2 mutations is on the verge of white heat
Time of Update: 2021-02-12
Recently, due to the prominent performance of PARP inhibitors in the treatment of breast and ovarian cancer, the research and development of PARP inhibitors for BRCA1/2 mutations and the fierce market competition have rapidly increased, which has aroused the interest of many drug developers.
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$100 million to help solid tumor immunotherapy enter the clinical phase, Genente update research and development cooperation
Time of Update: 2021-02-12
Today, Immunocore, the industry's leading T-cell-subject (TCR) biotech company, announced that it has signed a new research and development cooperation agreement with Roche's Genentech to jointly develop Immunocore's candidate therapy, IMC-C103C.
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Targeting MDM2-p53 degradation presents a new opportunity for the development of MDM2-p53 inhibitors
Time of Update: 2021-02-12
MDM2 is one of the strongest apoptosis inhibitors ever found, is a cancer gene closely related to malignant tumors, which can regulate p53's various functions, including directly blocking p53's N-end transcriptional activity domain, promoting p53 from the nucleus to cytoprotein, and as an E3 connective enzyme to make p53 ubibination so that p53 degrades.
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Uncovering the mature mechanisms for the production of NK cells promises to lead to the development of new immunotherapy for cancer and infectious diseases
Time of Update: 2021-02-12
researcher Ewa Sitnicka explains that without the Notch signaling path, NK cells would not mature properly and their numbers would decline, which is important for NK cells to fight cancer and infectious diseases effectively; (Bio Valley)
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Will sugar actually prevent the slimming gut bacteria from settling down?
Time of Update: 2021-02-12
Studies have shown that even if the diet is rich in glucose and sucrose, the modified BT bacteria remain unaffected and settle strongly in the guts of mice.
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Identification of new methods for drug candidates for Alzheimer's disease
Time of Update: 2021-02-12
For this reason and based on the results of their previous studies, the team said that non-cersone, curculin and three Alzheimer's disease candidates all met the definition of geostational protectors.
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New research could help treat Alzheimer's disease
Time of Update: 2021-02-12
the study provides a comprehensive review of clinical trials, including ongoing research into drugs used to prevent and treat Alzheimer's disease (and other dementias), noting the need to develop and test drugs based on an understanding of the multiple effects of aging on the brain.
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Peking University has made a breakthrough in the analysis of protease body full atomic dynamics
Time of Update: 2021-02-12
And through the combination of frozen electron microscope and machine learning technology, the paper analyzes the high-resolution (2.8 to 3.6 E) fine atomic structure of 7 intermediate-state configurations in the process of degradation of human-origin protease 26S, preferably with a local resolution of 2.5 E.
