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Science: Uncover the mystery of cancer cell immortality, TPP1 and TERT promoter mutations, synergistically lengthening telomeres
Time of Update: 2022-11-25
Dr. Pattra Chun-on in Jonathan Alder's lab was determined to find the missing link between melanoma, a mutation in the promoter of the TERT gene, and long telomeres.
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After chemotherapy, be sure to do one thing well! Of vital importance!
Time of Update: 2022-11-25
There are many test items for blood routine, and we pick the most commonly used introductions:Routine blood checklist White blood cell count (WBC)The most common significance of the white blood cell count is that its value is elevated to indicate possible infection, in addition to other diseases such as leukemia, and its decrease may be aplastic anemia, hypersplenism, severe sepsis.
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Let's talk about self-exempt targets: IL-17 and Th17 cells
Time of Update: 2022-11-25
Role of IL-17 in infection immunityFungal infectionsThere is convincing evidence from experiments on IL-17 polymorphisms and gene knockout mice that IL-17-secreting cells play a central role in the protective immunity of Candida and other fungal pathogens.
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Clin Cancer Res: Activity and safety of the BET protein inhibitor Molibresib in hematologic malignancies
Time of Update: 2022-11-25
CCR-22-1284 Bromodomains (BRD) are conserved modules located in chromatin-associated proteins that regulate the chromatin templating process by recognizing acetylated histones as epigenetic readings.
CCR-22-1284 Bromodomains (BRD) are conserved modules located in chromatin-associated proteins that regulate the chromatin templating process by recognizing acetylated histones as epigenetic readings.
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What do you know about tumor screening? 10 types of high-incidence tumor screening and prevention!
Time of Update: 2022-11-25
Screening recommendationsAge> 40 years old, abdominal pain, bloating, acid reflux, heartburn and other epigastric discomfort symptoms, and chronic gastritis, gastric mucosal intestinal metaplasia, gastric polyps, residual stomach, gastric giant fold sign, chronic gastric ulcer and gastric epithelial dysplasia and other lesions or conditions, as well as patients with a family history of tumors, should be regularly gastroscopy according to the doctor's recommendation.
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European Radiology: Dual-energy CT provides better imaging predictive markers for patients with metastatic renal cell carcinoma
Time of Update: 2022-11-25
Subsequently, the patient showed a complete response, did not progress the disease, and is still alive; Follow-up: more than 21 monthsThis study shows that the early reduction of DL-CT-derived ΔIC (combined) and ΔZeffective (combined) can be used as an independent imaging predictor of favorable prognosis in patients with mRCC, which provides an imaging reference for the formulation of clinical personalized treatment plan.
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European Radiology: Are you still worried about the discomfort of mammography and mammography?
Time of Update: 2022-11-25
Recently, a study published in the journal European Radiology used PGMI classification to evaluate the clinical quality of Senographe Pristina's patient-assisted compression (PAC) and standard compression (SC) mode in mammography examination, which provided a reference and technical support for improving patient compliance and breast cancer diagnosis rate.
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Lancet Haematol: Efficacy of Brentuximab vedotin in combination with nivolumab as consolidation therapy after HSCT for high-risk refractory/recurrent classical Hodgkin lymphoma
Time of Update: 2022-11-25
1016/S2352-3026(22)00318-0 After autologous hematopoietic stem cell transplantation (HSCT), consolidation therapy with Brentuximab vedotin prolongs progression-free survival in patients with high-risk relapsed or refractory classical Hodgkin lymphoma compared with placebo.
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How to correctly exert the efficacy of bevacizumab, you and I need to know
Time of Update: 2022-11-25
Stage III/IV disease after initial surgical resection: the recommended dose of bevacizumab is 15 mg/kg once every 3 weeks (15 mg/kg/q3w), combined with paclitaxel + carboplatin chemotherapy regimen for up to 6 cycles, followed by bevacizumab alone 15 mg/kg/q3w; The total medication time of this drug is up to 22 cycles or continuous use until the disease progresses, whichever occurs first;Platinum-resistantA.
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What happened to my liver? How to prevent and respond to liver function damage during targeted therapy?
Time of Update: 2022-11-25
A small number of patients will have elevated bilirubin (TBil) or alkaline phosphatase (ALP) in targeted therapy, both of which are also important indicators of liver function, and the underlying disease and local metastatic compression are excluded according to the treatment process and related tests (hepatobiliary imaging), and can also be considered as side effects of targeted therapy.
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Eur Urol Oncol: What is the real-world practice model and safety of radiotherapy and cabozantinib in combination for metastatic renal cell carcinoma?
Time of Update: 2022-11-25
in this real-world study of patients treated with mRCC with cabozantinib, 53% of patients received radiation therapy at the same time, and within 90 days of receiving radiotherapy, few reports of grade 3-4 AEs were reported Original source:Original source:Chun Loo Gan， Jiaming Huang， Elizabeth Pan et al.
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JAMA Oncol: Hereditary cancer susceptibility gene variants in patients with appendix cancer
Time of Update: 2022-11-25
8%) patients carried harmful variants in other cancer susceptibility genes (1 case APC [c.
8%) patients carried harmful variants in other cancer susceptibility genes (1 case APC [c.
8%) patients carried harmful variants in other cancer susceptibility genes (1 case APC [c.
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European Radiology: CMR assessment of myocardial microvascular function in patients undergoing chemotherapy for gynecologic malignancies
Time of Update: 2022-11-25
Abbreviations: CMR = Cardiac Magnetic Resonance; PI = Perfusion IndexThis study found that continuous chemotherapy was associated with myocardial microvascular dysfunction in patients with gynecological malignancies, but there was no trend of aggravation.
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Key points of imaging diagnosis| brain parenchymal metastases, other intracranial metastases
Time of Update: 2022-11-25
(Left) In a colon cancer patient, axial T2WI MR showed multiple metastases in the gray-white matter junction, and the lesions were mainly equal signals relative to brain tissue, surrounded by edema of varying strength.
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What is the use of the ovary, and how can stem cells solve the ovarian crisis in modern women?
Time of Update: 2022-11-25
Among them, the Reproductive Medicine Center of Nanjing Gulou Hospital and the team of Professor Dai Jianwu of the Institute of Genetics and Development of the Chinese Academy of Sciences carried out clinical research projects such as "Clinical Research on Umbilical Cord Mesenchymal Stem Cell Treatment of Early-onset Ovarian Insufficiency" and "Clinical Research on Umbilical Cord Mesenchymal Stem Cell Transplantation Intervention in Patients with Premature Ovarian Failure and Infertility", mainly focusing on stem cell therapy for ovarian function.
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Nature: Ning Zhang/Zemin Zhang/Jiye Zhu collaborated to reveal immune microenvironment subtypes and neutrophil heterogeneity in liver cancer
Time of Update: 2022-11-25
This study defines for the first time the five immune microenvironment subtypes of liver cancer at single-cell accuracy, and is named the TIMELASER typing system, which comprehensively reveals the heterogeneity of tumor-associated neutrophils (TAN) for the first time, verifies the pro-tumor mechanism of two key subsets of CCL4+ and PD-L1+ TAN, and finally constructs a mouse liver cancer model from the three levels of In vitro, Ex vivo, and In vivo.
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European Radiology: The value of PET/CT in evaluating the effectiveness of radiotherapy in patients with metastatic nasopharyngeal carcinoma
Time of Update: 2022-11-25
While DRT confers a clear prognostic advantage (in terms of improving PFS and OS rates) for patients in the low- and intermediate-risk tiers, this benefit does not extend to patients in the high-risk tierThis study shows that the Deauville score is appropriate for risk classification in patients with mNPC.
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For unresectable NSCLC, the focus cannot be limited to PACIFIC, but also needs to focus on more immune sequels
Time of Update: 2022-11-25
Currently, the standard of care for patients with unresectable stage III NSCLC is concurrent chemoradiotherapy (cCRT) sequential duvalumab consolidation therapy.
Currently, the standard of care for patients with unresectable stage III NSCLC is concurrent chemoradiotherapy (cCRT) sequential duvalumab consolidation therapy.
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【Review】Research progress of selective CDK inhibitors
Time of Update: 2022-11-25
Figure: Avotaciclib's design strategy, chemical structure, and CDK inhibitory activityAvotaciclib (BEY1107, 18) is an orally available CDK1 inhibitor currently in Phase I/II clinical trials for the treatment of locally advanced or metastatic pancreatic cancer (NCT03579836) as a monotherapy agent or in combination with gemcitabine.
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PARP inhibitor indications withdrawn one after another Where does the back-line treatment of ovarian cancer go?
Time of Update: 2022-11-25
In September 2020, niraparib was approved for the second indication in China for the treatment of adult patients with advanced epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer after achieving complete or partial response to first-line platinum-containing chemotherapy.
