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to identify five tumor microenvironments and clarify multiple mechanisms of cancer-promoting neutrophils
Time of Update: 2023-01-06
This time, the team of Zhang Ning, Zhang Zemin and Zhu Jiye of Peking University cooperated to perform single-cell RNA sequencing analysis based on patient samples and mouse samples, define five immune microenvironment subtypes of liver cancer, and also reveal the significance of tumor-associated neutrophils in the progression of liver cancer, and found that neutrophil depletion can reduce tumor burden and inhibit the progression of liver cancer in mice [2].
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to identify five tumor microenvironments and clarify multiple mechanisms of cancer-promoting neutrophils
Time of Update: 2023-01-06
This time, the team of Zhang Ning, Zhang Zemin and Zhu Jiye of Peking University cooperated to perform single-cell RNA sequencing analysis based on patient samples and mouse samples, define five immune microenvironment subtypes of liver cancer, and also reveal the significance of tumor-associated neutrophils in the progression of liver cancer, and found that neutrophil depletion can reduce tumor burden and inhibit the progression of liver cancer in mice [2].
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of malignant phenotype and tumor microenvironment of small bowel adenocarcinoma
Time of Update: 2022-10-03
This article is the original of the translational medicine network, please indicate the source when reprinting Author: MiaSmall bowel adenocarcinoma (SBA) is a rare malignant tumor with high mortality
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Single-cell multi-omics analysis provides an in-depth analysis of the tumor microenvironment of pancreatic cancer
Time of Update: 2022-09-30
They paid particular attention to cells that express acinar markers, as one theory suggests that pancreatic ductal adenocarcinoma originates from acinar cells that undergo acinar-duct metaplasia (ADM).
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Single-cell multi-omics analysis provides an in-depth analysis of the tumor microenvironment of pancreatic cancer
Time of Update: 2022-09-30
They paid particular attention to cells that express acinar markers, as one theory suggests that pancreatic ductal adenocarcinoma originates from acinar cells that undergo acinar-duct metaplasia (ADM).
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[Nat Med] Tumor immune microenvironment plays a decisive role in car T treatment for large B-cell lymphoma
Time of Update: 2022-09-14
evaluated TME in patients with DLBCL who received CAR T (Axicabtagene ciloleucel, axi-cel) in the ZUMA-1 Phase II study, and the results showed that the immune content of TME was associated with clinical response, survival, and toxic outcomes.
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Cell Rep: Discovery of a new pathway for DNA transfer in the tumor microenvironment
Time of Update: 2022-04-25
"We've shown that DNA is present in these microvesicles with transference, and now we have an excellent platform to assess genetic aberrations," said D'Souza-Schorey, who is also affiliated with the Berthiaume Institute for Precision Health, Boler-Parseghian Center for Rare and Neglected Diseases and Harper Cancer Institute .
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Basement membrane protein in tumor microenvironment inhibits T cell activation and promotes tumorigenesis
Time of Update: 2022-03-06
TRS_Editor A{font-family:;font-size:12pt;} On January 28, the international academic journal Journal of Molecular Cell Biology (JMCB) published online the latest achievement "Basement membrane promotes tumor development" by Ge Gaoxiang's research group at the Center for Excellence in Molecular Cell Science (Institute of Biochemistry and Cell Biology), Chinese Academy of Sciences.
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Chinese and foreign scholars found that liver microenvironment reprograms tumor cells to promote liver metastasis of colorectal cancer
Time of Update: 2021-08-28
The treatment strategy of rectal cancer liver metastasis shows that inhibitors targeting HGF and DPP4 can significantly inhibit the metastasis of colorectal cancer and prolong the survival time of tumor-bearing mice .
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Dev Cell: Zhou Jun and others analyze the impact of tumor microenvironment on tumor growth
Time of Update: 2021-08-01
On June 30, 2021, the German Cancer Research Center and the Michael Boutros group of Heidelberg University published an online research paper titled: Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth in the Journal of Developmental Cell .
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and application of single cell technology in the field of tumor microenvironment and immunotherapy
Time of Update: 2021-05-20
: Insights Gained from Single-Cell Analysis of Immune Cells in the Tumor MicroenvironmentThis review system summarizes the recent research progress of single-cell transcriptome technology in the analysis of tumor microenvironment, including the new characteristics of infiltrating T cells and myeloid immune cells, as well as its application and potential in revealing tumor immunotherapy mechanisms.
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Harvard scientists discovered an anti-cancer target that can not only affect tumor cells
Time of Update: 2021-04-27
Specifically, not only has the anti-cancer activity of T cells increased, but also the ability of T cells whose Carm1 gene has been knocked out to enter tumors has also increased.
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Harvard scientists discovered an anti-cancer target that can not only affect tumor cells
Time of Update: 2021-03-26
Specifically, not only has the anti-cancer activity of T cells increased, but also the ability of T cells whose Carm1 gene has been knocked out to enter tumors has also increased.
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Clini Cancer Research: Effects of ADT Joint Cy/GVAX Treatment on Microenvironment T-Cell Immersion of Prostate Tumors
Time of Update: 2020-07-14
BACKGROUND: Previous studies have shown that androgen deprivation therapy (ADT) promotes anti-tumor immunity in prostate cancer But it remains unclear whether a vaccine-based approach can amplify
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Cell Death Dis: Genetic trajectory and tumor microenvironment of pulmonary-specific oligosastatic colorectal cancer
Time of Update: 2020-05-29
Colorectal cancer (CRC) is the third most common tumor in the world and the second leading cause of cancer-related death In clinical practice studies, most metastatic CRC patients exhibit diffuse c
