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Phytomedicine:M13, an anthraquinone compound isolated from Euphorbia that promotes osteogenic differentiation of mesenchymal stem cells
Time of Update: 2023-01-04
M13 had a significant effect on the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cellsIn terms of mechanism, M13 strongly interacts with the docking site of the WNT signaling complex, thereby activating the WNT/β-catenin pathway.
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to induce the differentiation and regeneration of NK cells from human pluripotent stem cells
Time of Update: 2022-11-26
On November 8, 2022, the research team of Wang Jinyong, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, and Beijing Institute of Stem Cell and Regenerative Medicine, published an online report on Cell Discovery Research paper on the Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells.
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Human induced pluripotent stem cells differentiate into hypothalamic vasopressin neurons
Time of Update: 2022-11-04
Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state.
Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state.
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A special type of droplet related to stem cell differentiation could provide a target for new cancer therapies
Time of Update: 2022-10-13
In studying the stem cell differentiation pathway, researchers at the University of California, Santa Barbara, found that all the proteins involved did not form assembly lines or rigid structures, but combined into a single droplet.
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The Chinese team discovered a new method for safe induction of pluripotent stem cells, which
Time of Update: 2022-09-20
New methods for the safe induction of pluripotent stem cells have been "cracked". Recently, Yang Xin's team from Cardiff University in the United Kingdom and Wuhan Ruijian Pharmaceutical team publish
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Human periodontal membrane stem cells undergo cyclic mechanical stress to stimulate osteogenesis differentiation under the relevant signaling pathways
Time of Update: 2022-09-14
Next, in order to confirm the participation of the PI3K/Akt signaling pathway in the activation of Nrf2 in PDLSC during bone-form differentiation stimulated by cyclic mechanical stress, LY294002 was applied in the study based on KEGG pathway analysis.
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Targeting ZNF117 induces differentiation of GBM stem cells into oligodendrocyte lineage
Time of Update: 2022-08-20
Jun Liu of Yale University Neurosurgery and colleagues combined genome-wide image-based RNAi screening with single-cell sequencing (scRNA-seq) to detect zinc finger protein 117 (ZNF117, or H-PLK) as a regulator of GSCs differentiation .
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New discovery: "Lipid droplet nirvana" initiates a new model of pluripotent stem cell differentiation
Time of Update: 2022-08-10
Paper linkA schematic diagram of lipid droplet-mitochondrial interactions regulating epigenetics and cell fate On May 25, Cell Death & Differentiation published online the latest research results of Liu Xingguo's team from Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences "Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation" (Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation".
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Guangzhou Health Center achieves targeted differentiation and regeneration of pluripotent stem cells B immune lineage
Time of Update: 2021-12-29
On December 10, Wang Jinyong's research group from Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published a research paper entitled Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors in Cellular & Molecular Immunology .
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Nature: Obesity makes hair follicle stem cells differentiate into sebaceous cells, causing irreversible hair loss
Time of Update: 2021-10-09
Recently, a study published in nature found that obesity changes the differentiation fate of hair follicle stem cells by activating certain inflammatory cytokine signals, making them differentiate into keratinocytes or sebum-secreting sebocytes on the skin surface instead of hair growth.
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LEUKEMIA: Circulating cytokines in patients with multiple myeloma inhibit osteoblast differentiation of adipose stem cells
Time of Update: 2021-09-29
90% of patients have osteolysis-related bone pain and spontaneous fractures as their main symptoms, but they may also be related to anemia, renal failure, hypercalcemia, spinal cord compression, and immunodeficiency .
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Tongji University Nature publication: A deep learning-based neural stem cell differentiation fate prediction system
Time of Update: 2021-08-10
The results show that the prediction system established by the research has high prediction accuracy in different differentiation days and differentiation directions of NSCs, and can accurately predict the future differentiation of cells after a short time processing of factors/small molecules/nanomaterials using flow cytometric single cell brightfield images Among them, the shortest directions of neurons, astrocytes and oligodendrocytes only take 1 day, 12 hours, and 1 day, respectively.
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Southern Medical University Cell publication: The important role of lysosomes in the multidirectional differentiation of mesenchymal stem cells
Time of Update: 2021-08-05
Loss of Vangl2 leads to the activation of CMA lysosomes, which selectively degrades the above-mentioned osteoinhibitory factors, thereby promoting the osteogenic differentiation of mesenchymal stem cells .
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FDA approves Vertex clinical test stem cell-derived fully differentiated islet cell therapy
Time of Update: 2021-03-12
Vertex plans to launch a phase 1/2 single-arm, open-label clinical trial in the first half of 2021, using VX-880 to treat patients with type 1 diabetes (T1D) with impaired and severe hypoglycemia.
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Scientists analyze in depth the basic molecular mechanisms of self-renewal and differentiation of intestinal stem cells
Time of Update: 2021-03-09
In a recent study published in the international journal Nature Cell Biology entitled "Non-canonical Wnt/PCP signaling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates", scientists from institutions such as the German Centre for Environmental Health Research have solved the molecular mechanisms of self-renewal and differentiation of intestinal stem cells.
