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Life Med: Liu Yan of Nanjing Medical University uses brain organoids to simulate high cholesterol exposure leading to neurodevelopmental abnormalities
Time of Update: 2022-10-25
Due to unhealthy diet and living habits, obesity has become a serious social health problem. Maternal obesity accompanied by increased cholesterol levels before or during pregnancy has been reported t
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Follow-up Question Series – Why is the brain sometimes blank? Does mental illness increase the risk of dementia? How do psychostimulants improve insomnia?
Time of Update: 2022-10-25
A recent article published in the top international journal PNAS brings us the latest research on thinking gaps.
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Transl Psychiatry—Yang Xun's team reveals the different neural mechanisms of schizophrenia in the reward expectation and reward outcome stages
Time of Update: 2022-10-25
On October 16, 2022, Yang Xun's team from the School of Public Administration of Chongqing University delivered a presentation at Translational Psychiatry "Neural substrates of reward anticipation and outcome in schizophrenia: a meta-analysis of fMRI findings in the monetary incentive delay task".
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Sci Transl Med: Niacin receptor HCAR2 regulates microglial response and AD progression
Time of Update: 2022-10-25
and activated HCAR2 using an FDA-approved niacin (Niaspan) preparation in 5xFAD mice, thereby reducing plaque load and neuronal dystrophy, reducing neuronal loss, and improving memory deficits, thereby mitigating amyloid-induced pathology, suggesting that the use of Niaspan may be a promising treatment for AD, specifically targeting neuroimmune responses.
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JAMA: High-frequency stimulation therapy for chronic nerve root pain after lumbar spine surgery
Time of Update: 2022-10-25
for patients with chronic nerve root pain after surgery for degenerative lumbar spine disease, high-frequency stimulation therapy had no significant effect Original source:Original source:Sozaburo Hara et al.
Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery A Randomized Clinical TrialJAMA
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Guidelines for the diagnosis and treatment of essential tremor
Time of Update: 2022-10-25
Propranolol, arrolol, and primidone are the preferred initial agents for ET and can be used in combination when monotherapy is ineffective; Botulinum toxin type A multipoint intramuscular injection may be effective in patients with head or voice tremors; Surgical treatment is suitable for patients with severe symptoms and refractory drugs.
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Mol Neurobiol—Zhu Lixin/Guo Jiasong team revealed the important role of the basement membrane protein Perlecan in the recovery of blood-spinal cord barrier function after spinal cord injury
Time of Update: 2022-10-25
) , Mol Neurobiol, 2022）In summary, the study shows that Perlecan is specifically localized to the blood-spinal barrier (BSCB) basement membrane, and the degradation and remodeling process occurs after spinal cord injury 。 Overexpression Perlecan inhibits the downstream ROCK/MLC signaling pathway by interacting with interginβ1, thereby inhibiting the inflammatory response and promoting blood-spinal cord barrier repair and neurological function recovery.
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Schizophrenia—Brain network hub and working memory performance in patients with schizophrenia
Time of Update: 2022-10-25
In summary, the results of the study reveal that patients with schizophrenia exhibit diffuse abnormalities in the hub center, especially in the ventral attention of the brain (VAN), the left orbitofrontal area (FPN), and the default mode network ().
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NEJM: Professors Wei Hu and Xinfeng Liu of the First Affiliated Hospital of USTC Publish the Efficacy and Safety of Arterial Thrombectomy for Acute Bassilar Artery Occlusion (ATTENTION Study)
Time of Update: 2022-10-25
The relevant comparison results are shown in the following figure: Image source: New England Journal of MedicineThere was also a significant advantage in the thrombectomy group across all secondary outcomes, with the proportion of patients in the embolectomy group having the ability to live independently within 90 days significantly better than the control group, and the benefit ratio was comparable to that of anterior circulation endovascular therapy compared with optimal medical therapy.
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Science: Microglia regulate neurodegeneration in Alzheimer's and Parkinson's diseases
Time of Update: 2022-10-25
A deep understanding of the pathways that regulate pruning and specific signals that guide microglia to engulf synapses can help identify potential therapeutic targets for cognitive decline and identify candidate biomarkers to quantify microglial dysfunction associated with synaptic loss.
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Attention should be paid to differentiating benign paroxysmal positional vertigo from vestibular migraine
Time of Update: 2022-10-25
Benign paroxysmal positional vertigo (BPPV) and vestibular migraine (VM) are different independent diseases with completely different treatment methods and the choice of treatment modality affects eff
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Basic knowledge of CT perfusion of cerebral ischemia
Time of Update: 2022-10-25
Perfusion imaging showed prolonged time to reach bee (TTP), and mean time to pass (MTT), rCBF, and local cerebral blood volume (rCBV) were normal.
Perfusion imaging showed prolonged time to reach bee (TTP), and mean time to pass (MTT), rCBF, and local cerebral blood volume (rCBV) were normal.
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Why doesn't scratching yourself itch? The latest research finds a neuroscience explanation
Time of Update: 2022-10-25
James from the Recessed Fei Temple qubit | Official number QbitAII don't know if you found it, you don't itch yourself much -But when others gently scratch your arm sockets, it is easy to make you itc
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Mol Psychiatry: A must-see for depression research [Review]: Summarize the six molecular mechanisms of depression from the perspective of synapses
Time of Update: 2022-10-25
Figure 2: Receptor-related signaling pathways of serotonin, opioids, and BDNF regulate neuronal activity and synaptic function2The neurotrophic factor hypothesisThe "neurotrophic hypothesis for depression" suggests that disruption of neurotrophic support is a key mechanism of MDD-related synaptic and brain-related functional changes.
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It only takes one month to be completely captured by sweets, and the sensitivity to sweetness drops by 50%! Don't worry, there is still help
Time of Update: 2022-10-25
Image source: 123RFAbout 4 weeks later, the researchers tested the response of the rat tongue to the associated taste nerve when exposed to different flavored liquids, which is responsible for transmitting taste information from the taste bud cells at the front of the tongue to the brain.
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Neurology: Socioeconomic status, aging (biological), and memory in a diverse national sample of older men and women in the United States
Time of Update: 2022-10-25
In a national sample of middle-aged and older adults, measurements of DNA methylation of senescence (biological) correlated differently with memory trajectories and SES in white, black, and Latino middle-aged and older adults.
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JAMA NEUROLOGY: ARB DRUGS NOT ONLY REDUCE HYPERTENSIVE DISORDERS, BUT ALSO SIGNIFICANTLY REDUCE THE INCIDENCE OF EPILEPSY
Time of Update: 2022-10-25
Patients treated with class 1 of the four antihypertensive drugs (β-blockers BBB, ARBs, ACE, ACE, and calcium-channel blockers [CCBs]) were matched using propensity scores.
Patients treated with class 1 of the four antihypertensive drugs (β-blockers BBB, ARBs, ACE, ACE, and calcium-channel blockers [CCBs]) were matched using propensity scores.
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Front aging neurosci: interaction of autophagy with NLRP3 inflammasomes in Alzheimer's and Parkinson's diseases
Time of Update: 2022-10-25
Numerous studies confirm that autophagy and pathological proteins interact in the development of neurodegenerative diseases.
Numerous studies confirm that autophagy and pathological proteins interact in the development of neurodegenerative diseases.
Numerous studies confirm that autophagy and pathological proteins interact in the development of neurodegenerative diseases.
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Mov Disord: A number of common blood markers can be used for early Parkinson's disease surveillance
Time of Update: 2022-10-25
analyzed well-characterized new-onset PD (DeNoPa) patient cohorts and matched HCs Different combinations of markers in longitudinal samples, assessing established markers of neuronal function, inflammation, and cardiovascular risk in deep phenotypic PD by high-throughput sandwich immune multiplex combinations.
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European Radiology: long-term prognosis compared with ultrasound-guided corticosteroid injections for Morton neuroma
Time of Update: 2022-10-25
D Transverse diameter (+) measured in the minor axis coronal planeThis study suggests that ultrasound-guided corticosteroid injections are more effective than blinded injections in patients with MN in the medium to long term.
