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【NEJM】The First Affiliated Hospital of China University of Science and Technology Releases Original Stroke Clinical Research Results!
Time of Update: 2022-10-26
The relevant comparison results are shown in the following figure:Image source: New England Journal of MedicineThe results of the ATTENTION study demonstrated that the proportion of patients in the acute basilar artery occlusion embolectomy group who achieved a better neurological prognosis within 90 days was significantly better than that in the optimal drug treatment group with a modified Rankin scale (mRS) to measure the neurological recovery of patients after stroke.
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This article explains in detail the prediction and coping strategies of thrombolytic bleeding complications
Time of Update: 2022-10-26
*For medical professionals onlyCan the risk of bleeding before thrombolysis be predicted in advance?Post-thrombolytic hemorrhagic transformation (HT) refers to a hemorrhagic stroke that occurs for a period of time after intravenous thrombolysis in patients with acute ischaemic stroke.
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Comparison of three treatment options for diabetic neuropathy pain
Time of Update: 2022-10-26
This article is from NEJM Journal WatchComparing Treatment Options for Painful Diabetic NeuropathyComparison of different treatment options for diabetic neuropathy painReviewed by Bruce Soloway, MDAll three regimens, including combination therapy when monotherapy fails, are equally effective.
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How to quickly grasp the diagnosis and treatment of cluster headache? Don't miss this flowchart
Time of Update: 2022-10-26
The main clinical features of CH and other trigeminal autonomic headaches[1] Note: PH is paroxysmal migraine; HC is persistent migraine headache3Other primary headaches Sometimes there can be a certain phenotypic overlap between migraine and CH, which can easily lead to misdiagnosis, and the onset time and degree of sleep headache are similar to CH, which may also lead to misdiagnosis, and the key points of differential diagnosis are shown in the following table.
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Nature: Challenge the classic sport mode! Scientists discover that neurons that control movement "spin in circles"
Time of Update: 2022-10-26
Figure 1: The population of neurons that control movement operates in a circular cycle2The BSG neural network mode simulates rotational dynamics patternsThe traditional push-pull structure organization does not explain the rotational dynamics patterns of these neuronal groups well, and the researchers developed a BSG (balanced sequence generator) network model to explain how spinal cord neurons are organized to drive rotational dynamics patterns, consisting of a network of interneurons and two or more nerve fibers that control movement.
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Studies have found that social isolation affects brain gene expression and is prone to tooth loss!
Time of Update: 2022-10-26
This article is the original of Translational Medicine Network, please indicate the source of reprintingAuthor: kopeStudies have shown that social isolation directly causes structural changes in the brain associated with memory, reduces brain volume, and is associated with a 26% increased risk of dementia.
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A new theory of Alzheimer's disease: may be a congenital autoimmune disease
Time of Update: 2022-10-26
Weaver, director of the Krembil Brain Institute at the University of Toronto, Canada, synthesized journal literature and patents in clinical neuroscience, systems biology, neurobiology, immunology, biochemistry, and drug design to propose the "AD squared" model (AD^ 2）。 The results, titled "Alzheimer's disease as an innate autoimmune disease (AD^2): A new molecular paradigm," were recently published in the journal Alzheimer's & Dementia.
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Why women are more likely to develop Alzheimer's disease
Time of Update: 2022-10-26
Because dysfunction of this balancing process can lead to abnormal accumulation of tau protein in Alzheimer's patients, Kang and co-senior author Jung-A Woo, assistant professor at Case Western Reserve University, conducted a study to investigate why this happens.
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The most complete classification of chronic alcohol toxic encephalopathy, worthy of collection!
Time of Update: 2022-10-26
In patients with long-term heavy drinking, some patients develop organic dementia of the brain, alcohol-dependent patients have repeated tremors, delirium, spasm seizures, acute or chronic progressive personality changes, mental retardation, memory impairment dementia state.
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The level of cell-free DNA in the blood may be a sign of early detection of dementia and weakness
Time of Update: 2022-10-26
*For medical professionals onlyA higher level of circulating cell-free DNA in the blood may mean a higher risk of chronic inflammation. Higher levels of circulating cell-free DNA in the blood may mean
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Neurons: Shocked, the neurons in the dish have learned to play games!
Time of Update: 2022-10-26
Resources:[1] style="letter-spacing: 0px;font-size: 12px;color: rgb(160, 160, 160);box-sizing: border-box;"> ADtaxiThe author of this articleDai Siyu*For medical professionals onlyWhat, the neurons in the dish have learned to play games?Although humans have always been keen to teach various animals and AI to play games, AlphaStar is even already playing StarCraft, but this is a cluster of neurons in a petri dish!
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Cell pain actually protects the intestines! Discover the mechanism by which pain-sensing neurons exert a protective effect on inflammatory bowel disease
Time of Update: 2022-10-26
Pain receptor neurons drive mucus production and intestinal barrier protection through the CGRP-RAMP1 axis (Figure from Cell) In summary, this study identifies a previously unrecognized pathway through which TRPV1+ nociceptive receptors innervated by the intestine regulate the composition of the intestinal flora, mediating tissue-protective processes against the background of persistent intestinal damage and inflammation.
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Differences in excitatory changes specific to different types of neurons in the prefrontal cortex of rats with an early life stress model of AMEM
Time of Update: 2022-10-26
Early life (embryo, newborn, early years, etc. ) is a critical period for brain development, and neglect in early life can have irreversible effects on nervous system and emotional development. In rec
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Nature sub-journal: Peng Junmin's team reveals a new mechanism by which RNA splicing defects lead to Alzheimer's disease
Time of Update: 2022-10-26
The research team created mouse models of RNA splicing errors and β-amyloid aggregation, which are closer to human Alzheimer's disease than previous animal models, using which U1 small ribonucleoprotein (U1 snRNP) was found Mediated dysfunction of RNA splicing can play a role in the pathogenesis of Alzheimer's disease by causing neuronal hyperexcitation and cognitive impairment.
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Mov Disord: A number of common blood markers can be used for early Parkinson's disease surveillance
Time of Update: 2022-10-25
analyzed well-characterized new-onset PD (DeNoPa) patient cohorts and matched HCs Different combinations of markers in longitudinal samples, assessing established markers of neuronal function, inflammation, and cardiovascular risk in deep phenotypic PD by high-throughput sandwich immune multiplex combinations.
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European Radiology: long-term prognosis compared with ultrasound-guided corticosteroid injections for Morton neuroma
Time of Update: 2022-10-25
D Transverse diameter (+) measured in the minor axis coronal planeThis study suggests that ultrasound-guided corticosteroid injections are more effective than blinded injections in patients with MN in the medium to long term.
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JAMA NEUROLOGY: ARB DRUGS NOT ONLY REDUCE HYPERTENSIVE DISORDERS, BUT ALSO SIGNIFICANTLY REDUCE THE INCIDENCE OF EPILEPSY
Time of Update: 2022-10-25
Patients treated with class 1 of the four antihypertensive drugs (β-blockers BBB, ARBs, ACE, ACE, and calcium-channel blockers [CCBs]) were matched using propensity scores.
Patients treated with class 1 of the four antihypertensive drugs (β-blockers BBB, ARBs, ACE, ACE, and calcium-channel blockers [CCBs]) were matched using propensity scores.
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Front aging neurosci: interaction of autophagy with NLRP3 inflammasomes in Alzheimer's and Parkinson's diseases
Time of Update: 2022-10-25
Numerous studies confirm that autophagy and pathological proteins interact in the development of neurodegenerative diseases.
Numerous studies confirm that autophagy and pathological proteins interact in the development of neurodegenerative diseases.
Numerous studies confirm that autophagy and pathological proteins interact in the development of neurodegenerative diseases.
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Neurology: Socioeconomic status, aging (biological), and memory in a diverse national sample of older men and women in the United States
Time of Update: 2022-10-25
In a national sample of middle-aged and older adults, measurements of DNA methylation of senescence (biological) correlated differently with memory trajectories and SES in white, black, and Latino middle-aged and older adults.
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It only takes one month to be completely captured by sweets, and the sensitivity to sweetness drops by 50%! Don't worry, there is still help
Time of Update: 2022-10-25
Image source: 123RFAbout 4 weeks later, the researchers tested the response of the rat tongue to the associated taste nerve when exposed to different flavored liquids, which is responsible for transmitting taste information from the taste bud cells at the front of the tongue to the brain.
