-
How is blood pressure managed perioperatively for endoscopic hematoma removal? These are key things to note
Time of Update: 2022-11-01
*For medical professionals only, refer to endoscopic hematoma removal combined with standardized and reasonable blood pressure management to improve the prognosis of patients with ICH.
*For medical professionals only, refer to endoscopic hematoma removal combined with standardized and reasonable blood pressure management to improve the prognosis of patients with ICH.
-
Science Two FTD-ALS genes induce TDP-43 pathology and degeneration
Time of Update: 2022-11-01
To study the role of these two genes in FTD-ALS, the team of Leonard Petrucelli/Yong-Jie Zhang of Mayo Clinic (first author: Dr. Wei Shao) published a paper in Science Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration, where TBK1 is phosphorylated upon repeated polymerization in C9orf72 and subsequently wrapped into aggregates (Aggregates) leads to loss of TBK1 activity, which eventually leads to neurodegeneration.
-
NPP—Xu Yun's research group revealed that microalbumin-positive interneurons in the prefrontal cortex play an important role in the regulation of mood disorders in the early stage of Alzheimer's disease
Time of Update: 2022-11-01
On October 13, 2022, Professor Xu Yun's team from the Drum Tower Hospital affiliated to Nanjing University School of Medicine was at Neuropsychopharmacology A report titled "Prefrontal parvalbumin interneurons deficits mediate early emotional dysfunction in," was published in NPP Alzheimer's disease" research paper, presenting PFC brain regions PV+ INs in AD Early mood disorders play an important role in the regulation.
-
Treatment still relies on "old" drugs from decades ago, how to solve the problem of stagnant research and development of new drugs for Parkinson's disease?
Time of Update: 2022-11-01
▲If you have any business needs, please long press to scan the QR code above, or▎WuXi AppTec content team editorFor the pharmaceutical industry, the research and development of new drugs for Parkinson's disease (PD) has always been a difficult "hard bone", although pharmaceutical companies have invested a lot of money and manpower over the years, but the clinical trials of new drugs for Parkinson's disease are often unsatisfactory.
-
Nature: Human-derived brain-like organs connect animal neural circuits to drive reward behavior
Time of Update: 2022-11-01
1038/s41586-022-05277-wThe images in the article are from referencesFigure 3: The neural circuit formed by hCO is functionalsummaryIn this paper, human-derived brain-like organs cultured in vitro were transplanted into rats, which can be successfully integrated into existing neural circuits and can play the function of regulating behavior.
-
Master the key points of "autoimmune encephalitis" treatment, it is enough to master this article
Time of Update: 2022-11-01
Studies have shown that about 97% (42/43) of patients with this disease received immunotherapy at the first onset of the disease, and first-line immunotherapy drugs include steroids, IVIg; Rarely, second-line immunotherapies such as rituximab, cyclophosphamide, mycophenolate mofetil, azathioprine, and tacrolimus are used.
-
Science Café Expert Review: Sleep to anxiety, listen to pain
Time of Update: 2022-11-01
。 SDS induces socially frustrated mice to sleep in the next few hours, and researchers such as researcher Yu Xiao from Imperial College London and Professor Dong Hailong's team at Xijing Hospital of the Fourth Military Medical University of China found that this restorative sleep activates a small number of nerve cells located in the ventral tegmental area (VTA) of the midbrain [1].
-
How is status epilepticus diagnosed and treated in children? Take a look at the latest Chinese expert consensus
Time of Update: 2022-11-01
Status epilepticus (SE) is one of the critical diseases of the children's nervous system characterized by persistent seizures and may cause damage to the nervous system and even multiple organs, with
-
Another way: efficiently delivers AAV to the brain through the nose, bypassing the blood-brain barrier
Time of Update: 2022-11-01
The study, which validates the team's previously developed focused ultrasound intranasal delivery (FUSIN) method in a mouse model for the first time, confirms that FUSIN is able to break through the blood-brain barrier (BBB) and convert adeno-associated viral vectors (AAV) is efficiently delivered to the brain through the nose.
-
Cerebrovascular disease can also be secondary to seizures, this article is a complete summary
Time of Update: 2022-11-01
Cerebrovascular disease can cause seizures, and often become the first symptom of its onset, at the same time seizures can also cause cerebrovascular diseases, thereby bringing difficulties to diagnos
-
Several typical neuroimaging signs
Time of Update: 2022-10-31
Although normal people can also have iron deposition in the brain, abnormal, age-inconsistent iron deposition is a feature of HSD, bilateral globus pallidus, substantia nigra symmetric iron-containing pigment deposition is the standard for pathological diagnosis of this disease, head MRI T2 weighting shows bilateral globus pallida symmetric high-intensity "tiger's eye sign" is the most characteristic manifestation of this disease.
-
Commun Bio: The epilepsy team of Xuanwu Hospital of Capital Medical University directly revealed the functional diversity of the basal ganglia of the human brain for the first time in the world
Time of Update: 2022-10-31
On October 23, 2022, Communications Biology published online a report from the epilepsy team of Xuanwu Hospital of Capital Medical University entitled “Intracranial direct electrical mapping reveals t
-
Stroke: occult stroke is a risk factor for stroke recurrence in patients with atrial fibrillation
Time of Update: 2022-10-31
Regarding the one-year cumulative incidence of recurrent ischaemic stroke and all-cause death, the two groups were compared using the Fine and Gray subdistributed hazard model and the Cox frailty model with non-stroke death as a competitive risk, respectively.
-
A case of chronic subdural hematoma after endoscopic third ventriculostomy
Time of Update: 2022-10-31
Massive cerebrospinal fluid loss during ETV surgery can displace the ventricular collapse cortex, resulting in enlargement of the subdural space.
Massive cerebrospinal fluid loss during ETV surgery can displace the ventricular collapse cortex, resulting in enlargement of the subdural space.
-
CD(IF=38) Zhili Huang/Weimin Qu/Fengfei Ding, Fudan University, reveal the underlying neural mechanisms of REM sleep termination and sleep continuation
Time of Update: 2022-10-31
Original link: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is 【iNature】iNaturePhysiological rapid eye movement (REM) sleep termination is essential for initiating non-rapid eye movement (NREM) sleep or wakefulness, while inhibition of excessive REM sleep is promising in the treatment of narcolepsy.
-
Annals of Neurology: Actigraphy enables home screening for REM behavioral disorders in Parkinson's disease
Time of Update: 2022-10-31
Finally, the method validated accuracy at home in non-PD patients with insomnia, either alone or associated with other sleep disorders, and without a history of RBD.
Finally, the method validated accuracy at home in non-PD patients with insomnia, either alone or associated with other sleep disorders, and without a history of RBD.
-
Phytomedicine: Therapeutic potential of Yuanzhi saponins in neurological diseases
Time of Update: 2022-10-31
Objective: This review aimed to summarize the traditional uses of Yuanzhi plants and discuss the latest phytochemical, pharmacological and toxicological research results, mainly related to the application of Yuanzhi saponins in the treatment of neurological diseases.
-
Stroke: occult cerebral infarction is a risk factor for stroke recurrence in patients with atrial fibrillation
Time of Update: 2022-10-31
The investigators compared the cumulative one-year incidence of ischemic stroke recurrence and all-cause mortality between the two groups, using the Fine and Gray subdistribution risk models and the Cox frailty model with non-stroke death as a competitive risk, respectively.
-
The whole course treatment strategy of sulfapride has been jointly created by many experts in the field of psychiatry!
Time of Update: 2022-10-31
1. 2 Application in patients with relapseSuch patients have relatively low sensitivity in terms of drug efficacy and adverse effects, and can take a relatively aggressive approach to therapeutics such as starting therapeutic dose, target dose, and time to complete dose titration in order to control or alleviate clinical symptoms and behavioral problems as soon as possible.
-
Medical Movie Boutique Imaging signs of cerebral vein embolism
Time of Update: 2022-10-31
(A, B), axial non-contrast CT, showing abnormally high-density opacities of the right transverse sinus and superior sagittal sinus, consistent with cerebral vein embolism (long white arrow).
(A, B), axial non-contrast CT, showing abnormally high-density opacities of the right transverse sinus and superior sagittal sinus, consistent with cerebral vein embolism (long white arrow).
