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Nature Reviews Neuroscience: The role of astrocytes in neurodegenerative diseases
Time of Update: 2022-11-26
Figure 1: Astrocyte physiological changes associated with neurodegenerative diseaseProteinopathies caused by the accumulation of specific proteins with aggregation ability in astrocytes and proteinopathies are common pathological markers of NDs, and Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) are characterized by amyloid β (Aβ), mutant Huntington protein (HTT), α-accumulation of synuclein and TDP43 is characterized.
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The Neuron-Niu Jianqin/Yi Chen Ju team discovered the coupling mechanism between the differentiation of oligodendrocytes and the formation of astrocytes foot processes in developing oligodendrocyte cells
Time of Update: 2022-11-26
On November 15, 2022, Niu Jianqin's team from Army Medical University, Yi Chenju's team from the Seventh Affiliated Hospital of Sun Yat-sen University, and the University of California, San Francisco Professor Stephen Fancy co-published in Neuron Research paper "Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during neocortical development.
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Cell Reports Zhang Jiyan's team revealed the presence and characteristics of hematopoietic stem cells in the meninges of adult mice
Time of Update: 2022-11-26
Written by | Niu Chunxiao, Zou Tao Responsible editor| Wang Sizhen Edited by Summer: Hemopoietic stem cells (HSCs). Surrounded by a hematopoietic microenvironment called niche in mammalian fetal liver
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Mechanism by which Nature APOE4 triggers Alzheimer's disease: impairing myelination through cholesterol dysregulation in oligodendrocytes
Time of Update: 2022-11-26
Written by | QiGenome-wide association studies have identified genetic variants associated with an increased risk of AD (Alzheimer's disease), with APOE4 showing the strongest association with increas
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Review of Chinese General Medicine: Exploration of the application value of neurofilament light chain protein in peripheral neuropathy
Time of Update: 2022-11-25
Cerebrospinal fluid NfL (cNfL) and/or serum NfL (sNfL) levels have shown great advantages in diagnosing neurodegenerative diseases, central nervous system demyelinating lesions, traumatic brain injury, infectious diseases such as Creutzfeldt-Jakob disease, genetic disorders such as Huntington's disease, and other neurological/psychiatric disorders, assessing disease activity, monitoring response to treatment, and determining prognosis, and, The evidence for cNfL and sNfL as very promising biomarkers for CNS disease is increasing.
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Scientists have revealed new insights into how Alzheimer's disease risk genes contribute to the disease
Time of Update: 2022-11-25
UK Institute of DementiaResearchers have discovered a new biological pathway that may be linked to Alzheimer's disease, led by Professor Paul Elliott of the UK Institute of Dementia Research (UK DRI) at Imperial College London 。 The findings, published in the Proceedings of the National Academy of Sciences (PNAS), provide new insights into the underlying mechanisms of the disease and may provide new targets for future drug discovery.
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Inside and outside to create a 1-hour golden treatment circle, Southern Medical University Southern Hospital is in action
Time of Update: 2022-11-25
In many people's impressions, stroke (commonly known as stroke) is a disease far away from us, but according to the latest statistics released by the National Health Commission, the total number of st
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Stroke Second Hospital of Zhejiang University: Reperfusion injury is associated with adverse outcomes in patients with reperfusion after thrombectomy
Time of Update: 2022-11-25
References:Reperfusion Injury Is Associated With Poor Outcome in Patients With Recanalization After Thrombectomy.
References:Reperfusion Injury Is Associated With Poor Outcome in Patients With Recanalization After Thrombectomy.
References:Reperfusion Injury Is Associated With Poor Outcome in Patients With Recanalization After Thrombectomy.
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Cell research reveals the structural basis of frogus family receptor recognition of itch polypeptides
Time of Update: 2022-11-25
On November 3, 2022, the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, published the research results entitled "Molecular recognition of itch-associated neuropeptides by bombesin receptors" online on Cell Research 。 This achievement is the first to report that the frogeetin family receptor Neuromedin B receptor (NMBR) and Gastrin-releasing peptide receptor (GRPR) bind endogenous polypeptide ligands - neuromedin B (NMB) and gastrin-releasing peptide (GRP), respectively.
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Nature sub-issue: Multimodal neuroimaging predicts brain circuits for nonsuicidal self-injury in patients with major depressive disorder
Time of Update: 2022-11-25
The results showed that MDD patients with a history of NSSI showed significant differences in right putamen gray matter volume (GMV), right upper orbitofrontal cortex ReHo, left globus pallidus, and putamen-center functional network differences compared with HCs. Compared with MDD participants without NSSI, subjects with NSSI in the past showed significant right superior temporal gyrus (STG) GMV, right lingual gyrus ReHo, sigma, and global efficiency, as well as differences in cerebellum-center functional networks.
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Organoids: The magic of stirred reactors for the preparation of organoids
Time of Update: 2022-11-25
A simple culture method for embryoid bodies and kidney-like organs using stirred reactor suspension to culture pluripotent stem cells[11]-05 - Concluding remarksStirred bioreactors have shown application value in some organoid types, helping the development of organoid technology.
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Science: How does the hippocampus selectively recruit neurons to consolidate memory?
Time of Update: 2022-11-25
During oscillations of ripples in vivoPreferential recruitment of AcD cellsRecent studies have shown significant morphological and functional inhibition between host cells in cortical networks, and found non-cellular origin (i.
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Molecular pathway connecting amyloid and mitochondrial pathology in Alzheimer's disease CHCHD6/APP
Time of Update: 2022-11-25
The authors' team observed a significant decrease in APP total protein levels and C99 fragment enhancement in CHCHD6 KO cells (Figure 3i).
The authors' team observed a significant decrease in APP total protein levels and C99 fragment enhancement in CHCHD6 KO cells (Figure 3i).
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Nature: A new mechanism for the regulation of synaptic plasticity: demystifying the role of synaptic vesicles in rapidly replenishing the key molecule SYT3
Time of Update: 2022-11-25
The model that found that SYT3 KO affects the release probability of tightly docked vesicles failed to reproduce the behavior of WT synapses [Fig. 3f,g], indicating that SYT3 binds to residual Ca2+ to accelerate vesicle docking, thereby having a great effect on vesicle replenishment during high-frequency activity.
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Mesenchymal stem cells and exosomes improve cognitive function in aging brains by promoting neurogenesis
Time of Update: 2022-11-25
Researchers from Jilin University wrote a review on the possible mechanisms by which exosomes secreted by mesenchymal stem cells improve cognitive function in aging brains.
Researchers from Jilin University wrote a review on the possible mechanisms by which exosomes secreted by mesenchymal stem cells improve cognitive function in aging brains.
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Neurology cases: Bing-Neel syndrome: a rare imitator of secondary normal-stress hydrocephalus
Time of Update: 2022-11-25
(Figure: A-B: CT confirms progressive ventricular enlargement; C: fluid decay reversal recovery sequence shows high intensification of fluid-fluid levels in the subarachnoid space and lateral ventricles; D: Contrast-enhanced T1 showed cavernous sinus thickening/strengthening[*]; E: T2WI can be seen with horsetail thickening; F: Spherical sediment in cerebrospinal fluid[*]) An 80-year-old man in remission with Waldenström macroglobulinemia (WM) presents with cognitive decline, broad-based shuffling gait and nocturia.
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Not only cephalosporin, you can't drink alcohol when you take these medicines! Beware of the risk of death
Time of Update: 2022-11-25
"Cephalosporin is wine, just go"This phrase is often said in jokesActually, a lot of people don't do it rightBut sometimes it's really not a jokeWhy is "cephalosporin + wine" likely to kill people?The
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After bleeding from the brainstem cavernous hemangioma, is the symptom "self-healing" when the symptoms improve?
Time of Update: 2022-11-25
Haochen couldn't believe it: "I insist on exercising every day, and I usually don't even have a cold, how did I suddenly become a brain tumor?" ”The doctor took the light film and said with an indifferent expression: "In a situation like yours, we can't operate, so it is recommended to go home to rest and observe conservative treatment.
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European Radiology: Use of iron-sensitive MRI in differentiating hereditary spastic paraplegia from other motor neuron diseases.
Time of Update: 2022-11-25
As a serendipitous finding, patients with UMN-ALS have superficial arachnoid lesions (arrows of C)This study suggests that iron-sensitive magnetic resonance imaging of the primary motor cortex can provide additional useful information for the clinical diagnosis and treatment of patients with sporadic adult-onset UMN syndrome, especially when the lower extremity is the only or first affected body area.
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"Alzheimer's disease" marker – a hot project on the rise
Time of Update: 2022-11-25
Research backgroundAlzheimer's disease (AD) is an insidious and slow-degenerative disease that is the most common form of senile dementia, accounting for an estimated 60 to 80 percent of total dementi
