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"Hand tremor" suspected Parkinson's disease? Diagnostic criteria see here!
Time of Update: 2022-12-04
Clinically diagnosed Parkinson's disease:There are no absolute exclusion criteria and warning signs.
Clinically diagnosed Parkinson's disease:There are no absolute exclusion criteria and warning signs.
Clinically diagnosed Parkinson's disease:There are no absolute exclusion criteria and warning signs.
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"Cool down" the brain! Science has brought a new dawn to epilepsy gene therapy, which is more effective than drugs
Time of Update: 2022-12-04
A recent study in Science made a major breakthrough in addressing this problem, and co-corresponding author Dr. Gabriele Lignani said: "We have developed gene therapies that can precisely target abnormally active neurons and restore their activity to normal.
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Cell: Cao Peng's team at the Beijing Institute of Biological Sciences reveals the neurobiological mechanism of the "nausea-vomiting" response
Time of Update: 2022-12-04
Effects of specific activation of DVC Tac1+→rVRG or DVC Tac1+→LPB neural circuits on SEA-induced nausea and retching responses In addition to food toxins, chemotherapy drugs, such as cisplatin and doxorubicin, can also trigger nausea and gagging.
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Nature Prenatal immunostress impairs microglial activity and neural circuits
Time of Update: 2022-12-04
Written by | A fishMicroglia are major immune cells in the brain that influence neural circuit connections and neuronal function [1]. As early as embryonic development, microglia penetrate into the ne
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ECTRIMS 2022 HOT TOPICS ABOUT NMOSD AND MS, THIS ARTICLE IS NOT TO BE MISSED!
Time of Update: 2022-12-04
*For medical professionals only, the 38th ECTRIMS Conference ended successfully, wonderful content, not to be missed! Among the central nervous system demyelinating diseases, neuromyelitis optica spec
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Delivering treatments for Parkinson's disease and ALS, mitochondrial target emerging received £16 million Series A financing
Time of Update: 2022-12-04
▲If you have any business needs, please press and hold to scan the QR code above, or▎WuXi AppTec content team editor Recently, NRG, an innovative neuroscience company targeting mitochondrial dysfunction Therapeutics has announced the completion of a £16 million Series A funding round.
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"Cell" sub-issue: Don't want to use your brain after work? That's right! Scientists found that after 6.5 hours of high-intensity mental work, "poisons" accumulate in the brain, resulting in dull thinking and physical exhaustion
Time of Update: 2022-12-04
In this regard, Mathias Pessiglione's team in-depth research found that the "metabolic waste" glutamate produced by brain processes accumulates in the area responsible for cognitive control in the brain, the lateral prefrontal cortex (lPFC), resulting in an increase in the "cost" required to activate lPFC, thereby triggering cognitive fatigue.
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iScience—Columbia University Peng Yueqing's team revealed that sensory input regulates abnormal EEG in mice with absence epilepsy through the thalamic cortex pathway
Time of Update: 2022-12-04
Written by - Hu Ruining, Peng Yueqing edited - Wang Sizhen, Fang Yiyi edited - Wang RuhuaAbsence epilepsy is a generalized seizure that is common in many neurodevelopmental disorders, and the hallmark
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Peng Dantao: The onset is hidden and complex How to treat cerebral small vessel disease?
Time of Update: 2022-12-04
" Professor Peng Dantao pointed out that in addition to the above clinical symptoms, imaging examination can find generalized white matter demyelination, lacunar status, microbleeding foci, new small infarction, perivascular space enlargement and other characteristics, suggesting that patients may suffer from cerebral small vessel disease.
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Mol Psychiatry—Xiaolei's team revealed the regulatory role and circuit mechanism of VTA D1 neurons on anxiety-like behavior
Time of Update: 2022-12-04
October 4, 2022, Institute of Brain Sciences, Fudan University/ The team of researchers from the State Key Laboratory of Medical Neurobiology by Xiaolei presented a paper in Molecular Psychiatry "D1 receptor-expressing neurons in ventral tegmental area alleviate mouse anxiety-like behaviors via glutamatergic projection to lateral septum" research paper, revealed The important role and neural circuit mechanism of D1 receptors and D1 neurons in the regulation of anxiety-like behavior in the ventral tegmental area (VTA).
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European Radiology: What is the clinical value of magnetic resonance imaging for patients with double vision or dizziness in the emergency department?
Time of Update: 2022-11-26
At this stage, computed tomography (CT) is still the most common imaging test in emergency departments (EDs), but CT has its inherent drawbacks, with acute ischaemic stroke missed in approximately 9% to 14% of patients with ED 。 Diagnostic imaging (CT or magnetic resonance imaging (MRI)) is used for about 40% of dizziness visits, or about 12% of the total annual cost of dizziness visits.
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Nature Sub-journal Hou Shengtao's team of Southern University of Science and Technology used deep brain stimulation to activate hypothalamic temperature-sensitive neurons to achieve hypothermia and protect the stroke brain
Time of Update: 2022-11-26
iNatureDuring or after cerebral ischemia, therapeutic hypothermia of 32-34 ° C has a protective effect on nerves. However, hypothermia triggered by peripheral cold sensors is ineffective and causes in
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The Neuron Niu Jianqin/Yi Chen Ju team discovered the coupling mechanism between oligodendroid precursor cell differentiation and astrocytes foot process formation
Time of Update: 2022-11-26
On November 15, 2022, the team of Niu Jianqin from the Army Medical University and the team of Yi Chenju from the Seventh Affiliated Hospital of Sun Yat-sen University jointly delivered a report on Neuron Astrocyte endfoot formation controls the termination of oligodendrocyte precursor cell perivascular migration during neocortical development.
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Cell Reports—Lee's team revealed the basis of the neural circuits underlying the occurrence of irritable psychiatric symptoms in Alzheimer's disease
Time of Update: 2022-11-26
Written by | Zhang ZhongyuResponsible editor| Wang SizhenEditor—Summer Leaf In addition to cognitive decline, Alzheimer's disease (AD) patients are often accompanied by neuropsychiatric symptoms such
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Neurology: Efficacy of endovascular thrombectomy in patients with acute stroke and cancer
Time of Update: 2022-11-26
A study published in Neurology used a large inpatient database, the National Inpatient Sample (NIS), to examine clinical outcomes in cancer patients undergoing EVT.
A study published in Neurology used a large inpatient database, the National Inpatient Sample (NIS), to examine clinical outcomes in cancer patients undergoing EVT.
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Nature Medin co-deposition with Aβ in blood vessels of the brain of Alzheimer's disease
Time of Update: 2022-11-26
Neher's research team from the University of Tübingen in Germany published an article in Nature titled Medin co-aggregates with vascular amyloid-β in Alzheimer's disease In AD patients and model mouse brain blood vessels, medin co-localized with Aβ, knocking out medin can inhibit Aβ deposition, AD patients have higher levels of MFGE8 expression, and are associated with cognitive decline.
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STM poly (ADP-ribose) (PAR) may be a potential therapeutic target for frontotemporal dementia
Time of Update: 2022-11-26
Rothstein's team from the Mayo Clinic in the United States co-published a paper titled Science Translational Medicine Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins, they demonstrate that PAR can induce R-DPR agglomeration and promote its induced SGs formation and TDP-43 aggregation, and that the absence of PAR can inhibit neurodegeneration。 Together, they identified PAR as a promoter of R-DPR toxicity that could serve as a potential target for the treatment of c9ALS/FTD.
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Mol Psychiatr—Guohua Zhang/Xiaolong Wang team at China Medical University reveals novel mechanisms of depressive disorder induced by chronic ethanol exposure
Time of Update: 2022-11-26
Original link: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is [iNature]iNatureEthanol, commonly known as alcohol, is one of the common abuse substances worldwide, chronic ethanol exposure can not only cause cognitive memory impairment, but also increase the risk of anxiety, depression and other mental disorders, but the specific mechanism of action is not clear.
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Cell Metab Ji Tong/Wang Xu/Sun Shuyang discovered a new mechanism of cancer pain regulating tumor development
Time of Update: 2022-11-26
This study reveals for the first time that tumor cells can actively "hijack" a type of sensory nerve that senses, conducts, and regulates cancer pain-nociceptive sensory nerves when faced with nutrient deficiency in the tumor microenvironment to maintain their own vigorous growth needs.
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Mechanism by which Nature APOE4 triggers Alzheimer's disease: impairing myelination through cholesterol dysregulation in oligodendrocytes
Time of Update: 2022-11-26
Written by | QiGenome-wide association studies have identified genetic variants associated with an increased risk of AD (Alzheimer's disease), with APOE4 showing the strongest association with increas
