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SCI Adv-He Xiaosong et al. reveal the physiological basis of network control theory applied to brain science research
Time of Update: 2023-01-01
Written by He Xiaosong - Wang Sizhen, Fang Yiyi edited - The dynamic neural activity in Wang Sizhen's brain all the time is the physiological basis of all human psychology and behavior. In recent year
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After 12 minutes of light, the memory becomes stronger! The team of Beijing Normal University published the results of human experiments on laser stimulation therapy
Time of Update: 2023-01-01
▲ Schematic diagram of the experimental process (Image source: Reference [1]) According to the experimental results published by the research team in Science Advances 1064nm photostimulation acting on the right prefrontal lobe can significantly improve the individual's visual working memory capacity, and can successfully recall 4~5 targets in the memory test, compared with the control group, visual working memory increased by 25%.
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Nature: Severe new crown disease may accelerate brain aging
Time of Update: 2023-01-01
Link to the paper: style="letter-spacing: normal;color: rgb(136, 136, 136);font-size: 12px;" _mstmutation="1" _istranslated="1"> Open reprint, welcome to forward to Moments and WeChat groups Written byWang CongEditorWang Duoyu TypesettingShui Chengwen COVID-19 is an acute respiratory disease caused by the new coronavirus (SARS-CoV-2) infection, which may be accompanied by neurological sequelae。 Previous studies have shown that the overall cognitive ability of severely ill patients infected with the new crown will be significantly reduced, equivalent to aging for 10 years.
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The Nat Commun-Chen Zhong/Wang team revealed a new mechanism by which astrocytes are involved in seizures
Time of Update: 2023-01-01
Written by - Zhao Junli edited - Wang Sizhen, Fang Yiyi edited - Wang Sizhen epilepsy It is one of the most common neurological diseases, affecting nearly 1% of the global population, and nearly one-t
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CRPS—Self-powered speech recognition system developed by Guo Wenxi/Wu Ronghui's research group of Xiamen University for the hearing impaired
Time of Update: 2022-12-30
The study first started from the fact that many hearing-impaired people only have hearing loss and intact vocal ability [6], based on the assumption that "only a limited vocabulary can well cover the communication needs of a specific situation", and finally established a reliance on STVS and CRM of the speech recognition system (Figure 1).
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Cell Reports - "Wet matches that stop epilepsy from igniting", Chen Zhong/Wang Yi's team analyzes the significance of epilepsy interseizure treatment
Time of Update: 2022-12-30
2020, 2022a,b; iScience, 2022, Science Adv, 2022）。 In this study, the researchers used early gene-driven cell labeling technology, combined with optogenetics, pharmacogenetics and other regulatory methods, to reveal for the first time the role of two groups of neurons with different functions related to epileptic states in the piriform cortex of the brain, which is related to the proposed "interictal phase" Activated clusters of neurons may be an important time window and therapeutic target for future epilepsy treatment.
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Aging Cell Du Yifeng's team reveals a new mechanism of long-term aerobic exercise against memory decline in Alzheimer's disease
Time of Update: 2022-12-30
, Aging Cell, 2022) Conclusion and discussion, inspiration and prospectsIn summary, this study reveals that long-term aerobic exercise can act on the BBB by promoting neuronal exosome delivery miR-532-5p through a variety of experimental methods in vitro, thereby improving its structure and function, and ultimately enhancing the trans-BBB of Aβ Clearing, improve learning and memory ability.
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Nature: Gut bacteria increase the desire to exercise by promoting brain pleasure
Time of Update: 2022-12-30
Link to paper: style="text-indent: 0em;letter-spacing: normal;color: rgb(136, 136, 136);font-size: 12px;" _mstmutation="1" _istranslated="1"> Open reprint, welcome to forward to Moments and WeChat groups Humans, like other mammals, are occupied by trillions of microorganisms, including bacteria, viruses, and fungi, collectively known as commensal flora.
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Xiong Man's research group of Brain Fudan Brain Hospital uses human striatal GABA neurons to efficiently repair hypoxia-ischemic damage to the basal ganglion circuits of the brain
Time of Update: 2022-12-30
iNatureNeonatal hypoxic-ischemic encephalopathy (HIE) refers to neonatal cerebral hypoxic-ischemic injury due to asphyxia and other reasons during the perinatal period. The incidence of HIE in live bi
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Nature: Deep brain stimulation can help treat Alzheimer's disease
Time of Update: 2022-12-30
The method can be used to treat motor neurological disorders(DBS) uses stereotaxic techniques to implant stimulation electrodes at specific targets in the brain for high-frequency electrical stimulation Thus, the excitability of the corresponding nuclear group is adjusted to achieve the therapeutic purpose.
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Brain Stimul—Wang Kai's group revealed that transcranial alternating current stimulation can improve language comprehension in patients with aphasia after stroke
Time of Update: 2022-12-30
Figure 1: Timeline and effect of transcranial alternating current stimulation (tACS) combined with speech-language therapy (SLT) in the treatment of chronic post-stroke aphasia (Source: Xie, XH.
Figure 1: Timeline and effect of transcranial alternating current stimulation (tACS) combined with speech-language therapy (SLT) in the treatment of chronic post-stroke aphasia (Source: Xie, XH.
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EMBO J—He Kaiwen's research group found that the function of small albumin-positive PV neurons in the cortex is regulated by time and sleep
Time of Update: 2022-12-30
Source—"Logical Neuroscience" sister public account "Lanhan Life Science" written by Zong Fang Jiao Responsible editor—Fang Yiyi， Edited by Wang Sizhen—Yang Binwei GABAergic neurons expressing small a
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Science/JCI Tao Wenjuan, Anhui Medical University/Zhi Zhang, University of Science and Technology of China, discovered the underlying mechanism of refentanil-induced hyperalgesia
Time of Update: 2022-12-30
In addition, on July 7, 2022, Zhang Zhi of the University of Science and Technology of China, Tao Wenjuan of Anhui Medical University, and Liu Yuanyuan of the National Institute of Health (NIH) jointly published a joint newsletter entitled "Sound induces analgesia through corticothalamic circuits" on Science Online The study paper found that the analgesic effect of sound depended on a low (5 dB) signal-to-noise ratio (SNR) relative to ambient noise in mice.
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Cell: Cerebrospinal fluid immune dysregulation is a new culprit for cognitive disorders such as Alzheimer's disease
Time of Update: 2022-12-30
In the cerebrospinal fluid of people with cognitive dysfunction, clonal dilated T cells cause damage to the brainAll in all, this study shows that the CSF immune system plays an important role in cognitive disorders such as Alzheimer's disease, It was found that the CXCL16-CXCR6 signaling pathway is the molecular mechanism by which antigen-specific T cells enter the brain.
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JCI Jun Liu/Yulei Deng/Yuanyuan Li of Shanghai Jiao Tong University found that soluble TREM2 levels are associated with the transition from mild cognitive impairment to Alzheimer's disease
Time of Update: 2022-12-30
Correlation between CSF and plasma sTREM2 levels in the CABLE cohort (Image from Journal of Clinical Investigation) In addition, a recent study showed that the proportion of sTREM2 and phosphorylated Tau (sTREM2/p-Tau) in CSF was associated with cognitive decline 。 Previous studies have shown that sTREM2 concentrations change dynamically during AD progression and peak in the early symptom phase, suggesting that an early increase in CSF sTREM2 can be used to predict MCI-to-AD conversion.
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【Nature】Sports addictive? Scientists reveal gut-brain axis signals that amplify the effect of motor reward
Time of Update: 2022-12-30
1038/s41586-022-05525-zThe images in the article are from referencesFigure 1: Reduced motor skills in mice after antibiotic treatment2Striatal dopamine drives mouse locomotionThe striatum is a key brain region that drives motivational behavior.
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Cell Immune system study of cerebrospinal fluid in aging population
Time of Update: 2022-12-30
On December 13, 2022, David Gate's research group from Northwestern University published a report in Cell titled Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive Impairment's article, Exploring the CSF Immune System by Single-Cell Transcriptional Profiling and Finding that the CXCL16-CXCR6 signaling pathway guides CD8+ T cells into the CSF.
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The new coronavirus causes retinal inflammation by gathering the eye through the trigeminal nerve and optic nerve
Time of Update: 2022-12-30
1038/s41467-022-35225-1The images in the article are from referencesFigure 2: SARS-CoV2 causes an increase in retinal inflammation3SARS-CoV2 infects the eye through the trigeminal and optic nervesTo study the route of SARS-CoV2 infection in the central eye, the researchers infected mice with nasal infection (IN), bronchial infection (IT), ventricular infection (IC), eye infection (ED), and tail vein injection (IV), and found that all other ways can infect the brain except eye infection.
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Review Article Recommendation Issue 2 - Selected Reviews of the Latest Frontiers in the Field of Neuroscience in Cell Journal (October 11-11, 2022)
Time of Update: 2022-12-30
Review Article Recommendation Topic Issue 1 - Cell Journal Latest Frontier Review Selection in the Field of Neuroscience (October 11, 2022) Welcome to scan the code to join Logical Neuroscience Literature Learning 2 Group Remarks Format: Name-- Field of study - degree/title/title/positionEnd of articleIn the central nervous system (CNS), numerous studies have demonstrated that microglia play a key role in regulating brain development, brain homeostasis, and disease progression.
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The Neuro Oncol/Bosden team revealed the molecular mechanism of abnormal activation of the ribosome biogenesis pathway in glioma stem cells
Time of Update: 2022-12-30
iNatureGlioblastoma (GBM) is the most common and deadly primary brain tumor in adults. Despite some progress in diagnosis and treatment, the prognosis for patients with GBM remains poor. GBM is classi
