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What is the judgment of benign and malignant pulmonary nodules? This is the most important point
Time of Update: 2023-01-04
Patient Information:Female 69 years oldInquiry Questions:Lung nodules are found one year ago to help diagnose, see if it is malignant. Whether or not to take medication:Yes, bye FuleImage display and
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FAN: Green tea improves cognitive function in middle-aged and elderly Chinese by improving antioxidant stress
Time of Update: 2023-01-04
In summary, regular drinking of green tea is related to the cognitive function of middle-aged and elderly people, mainly in terms of memory and executive function.
regular drinking of green tea is related to the cognitive function of middle-aged and elderly people, mainly in terms of memory and executive function.
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Science has confirmed that exercise stimulates specific areas of the brain to produce proteins that burn skeletal muscle fat
Time of Update: 2023-01-04
In a study published today in Science Advances, researchers from the State University of Campinas and the University of São Paulo in Brazil have for the first time characterized a neuromuscular circuit that links skeletal muscle fat burning to proteins in the brain.
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Neurology cases: bilateral solitary nucleus lesions associated with neurogenic respiratory failure
Time of Update: 2023-01-04
(Figure: Brain MRI at 2 years old shows typical "putaminal eye" sign [A, arrow]; MRI at 7 years of age showed progressive basal ganglia and glial hyperplasia and cortical atrophy [B], and bilateral symmetric signal changes in solitary bundle nuclei were seen on fluid decay reversal recovery sequences [C, arrow] and T2WI [D, arrow] A 7-year-old girl with MEGD(H)EL[3-methylpentenediouria, dystonia-deafness, (liver disease), encephalopathy, Leigh-like syndrome, SERAC1] presents with worsening respiratory compromise.
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BMC Med: cellular transcriptional changes in peripheral blood in Alzheimer's patients
Time of Update: 2023-01-04
Consistent with changes in the proportion of immune cells and previous studies, the researchers found that a large number of up-regulated and down-regulated genes in AD were significantly enriched in three-quarters of the dataset in neutrophil activation/degranulation and B/T cell receptor signaling pathways, respectively (Figure 2B, C).
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JAMA sub-journal: Predictors of atrial fibrillation in stroke patients due to large/small vessel disease
Time of Update: 2023-01-04
The Known Cause Stroke and Underlying Atrial Fibrillation (STROKE AF) trial found that about one in eight patients with a recent ischemic stroke due to large/small vessel disease had atrial fibrillation (AF) after a stroke detected by a pluggable heart monitor (ICM) at 12 months.
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Neurology: Genes predict smoking, alcohol consumption, and functional outcomes after ischemic stroke
Time of Update: 2023-01-04
Recently, a study published in Neurology used the Mendelian randomization (MR) framework to explore the genetically predicted relationship between smoking and alcohol consumption and post-stroke prognosis.
Recently, a study published in Neurology used the Mendelian randomization (MR) framework to explore the genetically predicted relationship between smoking and alcohol consumption and post-stroke prognosis.
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European Radiology: The value of quantitative assessment of MR iron in the diagnosis of ALS
Time of Update: 2023-01-04
This study shows that SWI provides a quantitative evaluation method for iron changes in the ALS motor cortex, which improves the diagnostic performance and clinical status assessment of ALS.
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Wang Xiaofei exposed that Xiao S took Snows to paralyze himself, what is Snow, and how big are the side effects?
Time of Update: 2023-01-04
The findings advocate a smaller dose of sleep medication and placebo medication strategy, a new approach that maximizes the clinical gains for individuals in falling asleep and staying asleep, while reducing side effects and cutting prescription drug costs.
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Sleep disorders and cardiovascular disease
Time of Update: 2023-01-04
Sleep disturbances have a high incidence in the general population. The most common sleep disorder is insomnia, followed by sleep-disordered breathing such as obstructive sleep apnea (OSA). Sleep diso
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Sun Yat-sen University research found that staying up late to watch the ball and catching up on sleep during the day increased the risk of fatty liver
Time of Update: 2023-01-04
The study showed that staying up late, napping, and snoring were all associated with a higher risk of metabolism-related fatty liver disease, with poor sleep at night and people who took long naps during the day having the highest risk of fatty liver.
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Brain Health Inventory of important research results in the field of stroke
Time of Update: 2023-01-04
0000000000201473）Osaka University, Japan: Irregular dinner times are associated with an increased risk of hemorrhagic stroke mortalityIn the study, researchers analyzed 28,625 men and 43,213 women, aged 40-79, who were free of cardiovascular disease and cancer at baseline.
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CT identifies patients with TIA who are at high risk of stroke
Time of Update: 2023-01-04
A new study shows that computed tomography (CT) results suggestive of acute ischemia can identify patients at high risk of impending stroke in patients with transient ischaemic attack (TIA) or non-disabling stroke.
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Neurology: relationship between regional cortical network atrophy and primary progressive aphasia dementia
Time of Update: 2023-01-04
These results suggest that baseline atrophy of the cortical network of nonverbal cognitive and affective functions is a valid predictor of progression to dementia in patients with PPA.
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Nature: Brain boundary macrophages cause cerebrospinal fluid flow disorders involved in the development of AD
Time of Update: 2023-01-04
Figure 2: Injection of macrophage colony-stimulating factor to improve cerebrospinal fluid flow disorders caused by agingSingle-cell sequencing found that PBM in AD model mice had phagocytosis, endocytosis and interferon γ signaling pathway, among which the expression of interferon γ receptor gene was significantly increased, and these signal changes also appeared in AD patients' tissues.
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Movement disorders: Parkinson's disease, bacterial butyrate is associated with epigenetic changes, or is associated with depressive symptoms
Time of Update: 2023-01-04
To test whether butyrate affects epigenetic markers in the blood and brain of PD patients, and whether this correlates with the severity of symptoms, Aoji Xie of Parkinson's Disease Center in Michigan, performed DNA methylation analysis of whole blood samples and neuronal tissue from PD patients and controls in both cohorts and linked these findings to gut microbiome and metabolite data in feces, as well as clinical symptoms.
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Cell sub-journal: Bao Lan's team reveals the molecular mechanism by which m6A-modified lncRNA regulates neurodevelopment
Time of Update: 2023-01-04
In summary, this study reveals the function of m6A dynamic modification of lncRNA in neuronal development to regulate mRNA translation by stabilizing RNA-binding proteins.
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JPD: plasma short-chain fatty acids can be used as biomarkers for differential diagnosis of multiple system atrophy and Parkinson's disease
Time of Update: 2023-01-04
Methods: The plasma short-chain fatty acid content of 25 patients with multisystem atrophy, 46 patients with Parkinson's disease and 46 healthy controls was detected by gas chromatography-mass spectrometry, and their demographic and clinical data were evaluated.
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Construct a three-dimensional map of neurotransmitter receptors in the human brain to map brain structure, dynamics, and cognitive function
Time of Update: 2023-01-04
PET images of neurotransmitter receptors and transportersReceptor distribution reflects structural and functional organizationTo quantify the potential for two brain regions to be modulated by endogenous or exogenous input similarity, the authors calculated the correlation of receptor-transporter fingerprints between paired brain regions (Figure 2A), called receptor similarity, similar to other commonly used measures of inter-region attribute similarity, including anatomical similarity, morphological similarity, genetic similarity, temporal profile similarity, and microstructural similarity.
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The molecular mechanism of APOE4 triggering AD was revealed and a promising treatment was found
Time of Update: 2023-01-04
Preface:The heritability rate of Alzheimer's disease (AD, also known as "senile dementia") is estimated to be between 50% and 80%, indicating that "heredity" is the most important risk factor after "a
