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Movement disorders: perivascular space and Parkinson's disease are closely related
Time of Update: 2023-01-04
Figure 1: Paper cover imageIn addition to PVS visible on MRI, other well-established neuroimaging-based markers of cerebral small vessel disease include periventricular and deep leukoplasia (WMHs).
Figure 1: Paper cover imageIn addition to PVS visible on MRI, other well-established neuroimaging-based markers of cerebral small vessel disease include periventricular and deep leukoplasia (WMHs).
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Don't put the back of your ear wrong! Mayo study: hearing impairment is strongly associated with dementia progression, with a 95% increased risk!
Time of Update: 2023-01-04
The study examined hearing loss and its potential link to the development of mild cognitive impairment and dementia using formal behavioral pure tone and speech audiometry, conducted exclusively by audiologists by the Mayo Clinic Aging Study (MCSA).
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Neurology: Association of data-driven high-intensity spatial features of white matter with different cerebral small vessel disease etiologies
Time of Update: 2023-01-04
The association of these WMH spatial patterns with vascular risk factors, amyloid-β PET, and imaging biomarkers of cerebral amyloid angiopathy (CAA) was evaluated, characterizing different forms of cerebral small vessel disease (CSVD) using multivariate regression.
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Will cavernous hemangiomas recur after total resection of difficult locations such as brainstem, cervical medullary, basal ganglia, and ventricles?
Time of Update: 2023-01-04
What is the probability of recurrence after surgery for brainstem cavernous hemangiomas complicated with venous malformations?35-year-old Xiaoling went to the local hospital for 1 month due to dizziness, nausea and vomiting, unstable walking center of gravity, tongue and facial numbness, cranial CT and MRI showed left pontine brain, left fourth ventricle high-density opacity, right cerebellar old hemorrhage, considering cavernous hemangiomas combined with venous malformations, doctors told that the location of cavernous hemangiomas is difficult and the operation is very risky.
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Neurology: Magnetic resonance shows perivascular spaces and dementia risk: Framingham Heart Study
Time of Update: 2023-01-04
MRI Visible Perivascular Spaces and Risk of Incident Dementia: The Framingham Heart Study [published online ahead of print, 2022 Sep 29].
MRI Visible Perivascular Spaces and Risk of Incident Dementia: The Framingham Heart Study [published online ahead of print, 2022 Sep 29].
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Science Blockbuster Special Issue: No Neuron Is an Island" 4 reviews reveal the importance of brain connectivity
Time of Update: 2023-01-04
Here, the authors review methods for integrating data describing neural connections and other patterns in rodent brain atlases and discuss how map-based workflows facilitate whole-brain analysis of neural network organization related to other aspects of neural architecture.
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Upright tilt test can be used for the diagnosis and differential diagnosis of a variety of diseases! Chinese expert consensus
Time of Update: 2023-01-04
The upright tilt test confirms the temporal correlation between cardiac arrest and loss of consciousness and predicts the effectiveness of pacemaker therapy.
The upright tilt test confirms the temporal correlation between cardiac arrest and loss of consciousness and predicts the effectiveness of pacemaker therapy.
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JAMA sub-journal: Predictors of atrial fibrillation in stroke patients due to large/small vessel disease
Time of Update: 2023-01-04
The Known Cause Stroke and Underlying Atrial Fibrillation (STROKE AF) trial found that about one in eight patients with a recent ischemic stroke due to large/small vessel disease had atrial fibrillation (AF) after a stroke detected by a pluggable heart monitor (ICM) at 12 months.
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European Radiology: The value of quantitative assessment of MR iron in the diagnosis of ALS
Time of Update: 2023-01-04
This study shows that SWI provides a quantitative evaluation method for iron changes in the ALS motor cortex, which improves the diagnostic performance and clinical status assessment of ALS.
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European Radiology: classification of leukoencephalopathy and imaging signs of small vessel lesions
Time of Update: 2023-01-04
Brain magnetic resonance imaging (MRI) findings, such as abnormal white matter signaling (WMSA), fissures, cerebral microhemorrhages (CMB), and perivascular space enlargement (EPVS), are important surrogate measures for SVD.
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Neurology: gender differences in intensity of care and prognosis for acute ischemic stroke patients of different ages
Time of Update: 2023-01-04
Sex Differences in Intensity of Care and Outcomes After Acute Ischemic Stroke Across the Age Continuum [published online ahead of print, 2022 Sep 30].
Sex Differences in Intensity of Care and Outcomes After Acute Ischemic Stroke Across the Age Continuum [published online ahead of print, 2022 Sep 30].
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Nature: New study identifies neurons that allow lumbar spinal epidural electrical stimulation to restore movement in paralyzed patients
Time of Update: 2023-01-04
In a new study, Courtine, Bloch, Squair, and their research team not only demonstrated the effectiveness of this therapy in 9 patients, but also sustained improvements in motor function after the neurological rehabilitation process ended and electrical stimulation was turned off.
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Alzheimer & Dementia: Long-term increased pulse pressure may indicate a trend in brain microstructural changes in older adults
Time of Update: 2023-01-04
midlife pulse pressure (PP) or pulse wave velocity (an alternative measure of arterial rigidity) can predict cognitive decline and dementia riskScholars at the University of San Diego studied the association between PP trajectories and brain microstructure measured by confined spectrum imaging in 146 community-dwelling older adults, whether microstructure mediated the association between PP trajectories and executive function, and whether the association with PP-restricted spectrum imaging was altered by the APOE-ε4 state.
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Detailed illustration: MRI staging and clinical coping strategies of cerebral infarction
Time of Update: 2023-01-04
1. Window (hyperacute) phase at the time of reflow: within 6 hours of the appearance of symptoms, during this period, there is often no clear manifestation on the head CT image or only a slight blurred white matter boundary or slightly low-density shadow; In conventional MRI images, there were no abnormal manifestations, high intensity in diffusion-weighted imaging (DWI), low dispersion coefficient (ADC) of water in each pixel of brain tissue, and low perfusion in perfusion MRI (PWI).
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Neurology: Relationship between the white matter network and the striatal dopamine depletion pattern in patients with Parkinson's disease
Time of Update: 2023-01-04
A study published in Neurology aims to explore whether the pattern of striatal dopamine depletion is related to the white matter network (WM) in Parkinson's disease patients.
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Science Advances: The Cao Xiong/Feng Yanqiu team found that astrocytes dysfunction led to abnormal resting functional connectivity in patients with depression
Time of Update: 2023-01-04
Recently, the team of Cao Xiong and Feng Yanqiu of Southern Medical University published a research paper entitled: Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression in Science Advances.
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AD literature reading: Nature—APOE4 drives myelin damage by inducing dysphenidrocytes cholesterol metabolism
Time of Update: 2023-01-04
Year-end inventory: Top ten major breakthroughs in single-cell omics research in neuroscience in 2021: 17 Nature+AD+neurodevelopmental + spatial transcriptomeList of the top ten research advances in 20201.
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Neurology: Genes predict smoking, alcohol consumption, and functional outcomes after ischemic stroke
Time of Update: 2023-01-04
Recently, a study published in Neurology used the Mendelian randomization (MR) framework to explore the genetically predicted relationship between smoking and alcohol consumption and post-stroke prognosis.
Recently, a study published in Neurology used the Mendelian randomization (MR) framework to explore the genetically predicted relationship between smoking and alcohol consumption and post-stroke prognosis.
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BMC Med: cellular transcriptional changes in peripheral blood in Alzheimer's patients
Time of Update: 2023-01-04
Consistent with changes in the proportion of immune cells and previous studies, the researchers found that a large number of up-regulated and down-regulated genes in AD were significantly enriched in three-quarters of the dataset in neutrophil activation/degranulation and B/T cell receptor signaling pathways, respectively (Figure 2B, C).
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Genetic testing shows a predisposition to Alzheimer's disease.
Time of Update: 2023-01-04
Genome-wide association analysis studies have shown that APOE4 is the strongest genetic risk factor for Alzheimer's disease, and APOE4 is present in 40%-50% of Alzheimer's disease patients.
