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Neurology |。 Midlife vascular risk and biomarkers have independent effects on long-term cognitive function
Time of Update: 2020-12-23
Midlife vascular risk and biomarkers, the effects on long-term cognitive function independently of each other in middle age, vascular risk factors (e.g. hypertension, diabetes) and amyloid, tau protein pathology biomarkers were associated with cognitive decline and an increased risk of clinical symptoms of dementia.
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NEJM: Effect of dexamisson on prognosis in patients with chronic epidural hematoma
Time of Update: 2020-12-23
748 patients participated in the study, including 375 in the dexamison group, 373 in the placebo group, with an average age of 74 years, 94 percent of patients who underwent hematoma removal surgery upon hospitalization, and 60 percent of the participants in the hospital rate between 1 and 3.
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Lilly has collaborated with Precision BioSciences on genome editing research
Time of Update: 2020-12-23
Lilly has entered into research partnerships and exclusive licensing agreements with Precision BioSciences to use genome editing to develop treatments for genetic diseases.
the main plan and initial focus of the agreement, which also involves two other unrealed genetic targets, will focus on Duchy muscular dystrophy (DMD).
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JNNP: Effects of oral food properties on inhalation and swallowing dynamics in patients treated with DBS
Time of Update: 2020-12-23
V2 group had more frequent inhalation (OR 1.71, p-0.019) and more frequent penetration and suction (OR 1.68, p-0.009) than V1, and no significant differences were found in the swallowing parameters of MBSImP and FOIS under DBS conditions in any visit.
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NAT COMMUN: How is memory consolidated?
Time of Update: 2020-12-23
Although it is common assumption that "on-demand" release determines the signaling of cannabinin, their rapid degradation is expected to control the time curve of the internal cannabinin action and may affect the conduction of neuron signals.
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Nature: Can't remember staying up late reviewing? Don't eat late-night memory better
Time of Update: 2020-12-23
study showed that fruit flies that ate after training needed sleep to consolidate their memory, while hungry fruit flies' memory was not affected by sleep deprivation.
sleep-dependent memory in general, the study found that fruit flies need sleep to form memories when they are full.
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Lancet: Taking Rimegepant once the next day can prevent migraines!
Time of Update: 2020-12-23
after a four-week observation period, eligible patients were randomly assigned to the Rimegepant group (75 mg, oral, 1 time/2 days) or placebo group for 12 weeks of continuous treatment.
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JNNP: Predicting the clinical characteristics of autoantibodies on the surface of neurons in patients with neo-epilepsy: the significance of immunotherapy
Time of Update: 2020-12-23
, these findings suggest that nonsteroidal anti-inflammatory drugs are tested in new epilepsy patients, but do not have adverse event characteristics and should not alter current clinical treatment.
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JNNP: Late Oncology Depression: A Cross-Sectional Study of Dopamine Deficiency and Pre-Parkinson's Disease Symptoms
Time of Update: 2020-12-23
study, which further enhanced the likelihood that LOD is a pre-existing condition of PD or DLB, showed that the clinical characteristics of motor and non-motor dysfunction in PD were more common in those with PARKINSON's disease with dopamine transporter scans that were abnormal than those scanned.
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J Vasc Surg: Asymptomatic cervical artery stenosis is associated with insufficient brain perfusion
Time of Update: 2020-12-22
To determine whether ACS causes insufficient brain perfusion, the researchers developed a new way to quantify the differences between brain perfusions in peak time (TTP) and average transmission time (MTT) delays in total brain perfusion-weighted magnetic resonance imaging (PWI).
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J Pediatr: The study identified risk factors associated with bacterial meningitis outcomes in children
Time of Update: 2020-12-22
study assessed 9,581 patients between the ages of 0 and 18 and suggested several credible and important prognostic factors to predict adverse outcomes after bacterial meningitis in children.
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Sci Rep: Eating more chocolate can improve the brain's cognitive abilities, especially for people who often handle complex tasks
Time of Update: 2020-12-22
researchers found that healthy adults were able to perform certain cognitive tasks more effectively and perform better in complex project tests after drinking flavanol-rich cocoa drinks.
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Stroke: Post-traumatic stress disorder, antidepressants, and hemorrhagic stroke
Time of Update: 2020-12-22
in a fully adjusted model, the effects of PTSD and SNRI decreased (adjusted HR of 1.03 (95% CI is 0.81-1.34) and adjusted HR was 1.19 (9) 5% CI is 0.83-1.71), but the use of SSRI is still associated with a 45% increase in the risk of hemorrhagic stroke (corrected HR is 1.45 (95% CI is 1.13-1.85).
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Li Xinyi: Diagnosis of ischemic stroke based on CISS parting
Time of Update: 2020-12-22
With the change of people's understanding of ischemic stroke from a "disease" to a "clinical syndrome" concept, and the beginning of the treatment of different ischemic stroke patients based on the cause, the significance of ischemic stroke's cause credit type is even more important.
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JNNP: Synactal nucleoprotein disease as a pathological biomarker of primary REM sleep behavior disorder
Time of Update: 2020-12-22
When the two phosphate α-synaptic nucleoprotein (pAS) staining methods show inconsistent results, adjacent 5 m slices of the gastrointestinal and positive control brain (the cerebral cortitis of a patient with Louis dementia (DLB) are further dyed to check the staining quality and confirm the discovery.
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Neurology: Risk of stroke among cancer survivors
Time of Update: 2020-12-22
recently, a study published in Neurology, an authoritative journal in the field of neurology, looked at population-based, queue-based data to determine whether cancer survivors have a relatively high risk of stroke compared to non-cancer populations.
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Pediatrics: The new algorithm effectively distinguishes bacterial and sterile meningitis
Time of Update: 2020-12-22
recently, a Spanish study aimed at developing and validating a score (MSE) to distinguish between bacterial meningitis and aseptic meningitis in children with initial evaluation of meningitis in emergency departments has been published online in Pediatrics.
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JNNP: Optic neuroscolitis spectrum disorder: pregnancy-related seizures and predictive risk factors
Time of Update: 2020-12-22
this paper explores the effects of pregnancy on patients with optic neuroscolonitis spectrum disorder (NMOSD) and the risk factors for predicting pregnancy-related onset.
independent risk factors for predicting pregnancy-related seizures include age at birth/abortion (20-26.5, p=0.018; 26.5-33, p=0.001), AQP4 antibody titration (≥1:100, p=0.049) and inappropriate treatment during pregnancy and post-natal care (p=0.004).
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JNNP: Study of the plaque form of acute symptomatic intracranial arteriosclerosis
Time of Update: 2020-12-22
recruited adult patients with acute ishemotic stroke or transient cerebral isoemia attacks (TIA), which were attributed to the high level of ICAD (60%-99% stenosis) identified in 3DRA within 4 weeks of the onset of symptoms.
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Stroke: Analysis of acute cerebrovascular events in people infected with COVID-19
Time of Update: 2020-12-22
, however, it is not clear what the characteristics and outcomes of COVID-19 patients with stroke occurred.
patients with COVID-19-negative were more likely to have recessive stroke (51.8% vs.
results, COVID-19 negative and positive baseline characteristics of stroke patients are similar.
