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Nat Commun: A new mechanism for balancing emotional responses
Time of Update: 2020-12-26
endo-cannabinin is closely related to multiple aspects of emotional memory processing, the researchers found that the formation of memory through fear regulation selectively accelerates their weakness in the small brain.
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Nature: Don't eat late-night memory better
Time of Update: 2020-12-26
study showed that fruit flies that ate after training needed sleep to consolidate their memory, while hungry fruit flies' memory was not affected by sleep deprivation.
sleep-dependent memory in general, the study found that fruit flies need sleep to form memories when they are full.
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Front Cell Dev Biol: Gene therapy promotes nerve regeneration
Time of Update: 2020-12-26
In order to improve the efficiency of neuronal conversion and pave the way for future translation applications, Professor Chen's team further developed adeno-related virus systems (AAVs) to transfer NeuroD1 to divided and non-dividing astrocytes under the control of GFAP, a star cell promoter, and to confirm the transformation of star glial cells directly into neurons in the spinal cord.
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ACS sub-journal: Chinese and French scientists have teamed up to find that regulating copper ion levels in the brain is expected to reduce memory loss in Alzheimer's disease
Time of Update: 2020-12-26
results were published online December 16, 2020 in the journal ACS Chemical Neuroscience under the title "TDMQ20, a Specific Copper Chelator, Reduces Memory Wells in Alzheimer's Disease Model Mouses." from ACS Chemical Neuroscience, 2020, doi:10.1021/acschemneuro.0c00621.
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Science: Explore the two-way causal relationship between poverty and common mental illnesses
Time of Update: 2020-12-26
DECEMBER 17, 2020 /--- Researchers from the Massachusetts Institute of Technology and Harvard University in the Journal of Science published a review article titled "Poverty, depression, and anxiety: Causal evidence and mechanisms" that analyzed the relationship between poverty and poor mental health.
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Sugar-lowering drugs to treat Alzheimer's disease (AD)! Novo Nord launches a high-dose oral semaglutide (Smeglutide) Phase 3 clinical project!
Time of Update: 2020-12-26
currently, Novo Nord has developed injection preparations (Ozempic) and oral preparations (Rybelsus) for semaglutide:-Ozempic (semaglutide, injection preparation): a weekly sub-cortective injection preparation (0.5 mg or 1 mg) for: (1) as an aid to dietary adjustment and exercise to improve blood sugar control in adults with type 2 diabetes, (2) for adults with type 2 diabetes with cardiovascular disease (CVD), reducing the risk of major adverse cardiovascular events (MACE, including cardiovascular death, non-fatal heart attack, non-fatal stroke).
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Nat Neurosci: New research suggests the new coronavirus can enter the brain through a blood-brain barrier
Time of Update: 2020-12-25
a new study, researchers from research institutions such as the University of Washington School of Medicine in the United States found that SARS-CoV-2 prickly proteins can cross the blood-brain barrier in mice.
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Science Sub-Journal Interpretation! Reducing YKL-40 protein expression levels is expected to slow the progression of Alzheimer's disease
Time of Update: 2020-12-25
"If your circadian clock isn't quite right for years--- you're often suffering from nighttime sleep interruptions and daytime naps -- the cumulative effects of chronic disorders can affect the inflammatory pathway, allowing you to accumulate more amyloid plaques," said Dr. Erik Musiek, an associate professor of neurology at the University of Washington's St. Louis School of Medicine and author of the paper.
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Science Subp.: The new study details the dynamics of two protein markers of Huntington's disease in patients
Time of Update: 2020-12-25
study was published in the December 16, 2020 issue of the Journal of Science Translational Medicine under the title "Mutant Huntingtin and neurofilament light have a longitudinal dynamics in Huntington's Disease." longitudinal dynamics of mHTT and NfL over a 24-month 24-month 24-month 24-month 2020, doi:10.1126/scitranslmed.abc2888.
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Nature: Challenge traditional cognition! The characteristic selectivity of neurons comes from the total number of activated synapses
Time of Update: 2020-12-25
Sholl explains, "Our goal is to test the hypothesis that the reaction of strong synapses closely matches the characteristic selectivity of neurons, while weak synapses do not." to test this hypothesis, the researchers used optical microscope technology to visualize the activity of synth groups on individual neurons in real time.
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Nature: New uses for old medicines! New research reveals the molecular mechanisms of ketamine against depression
Time of Update: 2020-12-25
DECEMBER 20, 2020 /--- In a new study, researchers from McGill University, the University of Montreal and the University of Carlton in Canada found that a group of proteins involved in memory formation called 4E-BP is key to unlocking ketamine antidepressants in the brain.
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Mirogabalin's Phase III study on the treatment of central nervous pain after spinal cord injury has yielded positive results
Time of Update: 2020-12-24
the study was conducted in Asia (Japan, South Korea and Taiwan, China) in a double-blind manner to assess the efficacy and safety of Mirogabalin and placebo in patients with central nervous pain after 274 cases of spinal cord injury.
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JNNP: Relationship between cognitive function and daily life function after brain trauma
Time of Update: 2020-12-24
addition, there were significant differences in mental and physiological health outcomes of SF-12v2 in the GOSE 6-8b population, and there was no evidence to explain the similarity of cognitive performance between these groups.
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Lancet Neurology |。 2020 New Crown ravaged the world, a major clinical study of cerebrovascular disease
Time of Update: 2020-12-24
although in-vascular thrombosis has significantly improved functional outcomes in patients with acute ischemic stroke, many individuals treated have died or suffered severe disabilities.
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JNNP: C9orf72 is associated with pre-onset and plasma microRNA characteristics of frontal lobe dementia and amyotrophic lateral sclerosis
Time of Update: 2020-12-23
study aims to study the expression levels of plasma miRNAs in C9orf72 mutant carriers, including pre-symptom and clinical stages, to identify potential non-invasive biomarkers of C9orf72-related FTD and ALS preclinical and clinical progression.
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Acta Neuropathologica: Malignant transformation of polygonal low neurosurgery (PLNTY) in adolescents
Time of Update: 2020-12-23
, we report a child patient diagnosed with FGFR3-TACC3 fusion who underwent relapsed glioblastoma-like lesions within 18 months.
468 Gene Tumor Sequence Analysis (MSK-IMPACTTM) once again confirms FGFR3-TACC3 fusion, coupled with additional somatic cell changes in TP53, ATRX, PTEN, TEK, and RB1, which are common in high-level gliomas.
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J Neurointerv Surg: Arterial embolism in the meninges can be used as an auxiliary therapy for symptomatic chronic epidural hematoma surgery
Time of Update: 2020-12-23
From April 2018 to October 2018, 46 CSDH participants requiring surgery were prospectively randomized and underwent separate surgical treatment (ST group) or surgically assisted MMA embolism (ST-MMAE group).
, the results show that surgical intervention combined with MMA embolism can increase CSDH re-absorption 3 months after surgery.
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Lancet Neurology: The safety and effectiveness of Satralizumab's single-drug treatment for optic neurospinal cord disease spectrum disorder: a randomized, double-blind, multi-center, placebo-controlled Phase 3 trial
Time of Update: 2020-12-23
study is a Phase 3 randomized trial (SAkuraStar) that evaluates the safety and effectiveness of satralizumab monotherapy and placebo therapy for adult NMOSD patients.
, the use of satralizumab monotherapy in patients with NMOSD delayed and reduced recurrence rates, especially in patients with AQP4-IgG seroposes.
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Lancet Neurology: Prevalence, predictive factors, and prognosis of symptomatic intracranial stenosis in patients with transient ischemic episodes or mild stroke: a population-based queue study
Time of Update: 2020-12-23
this paper focuses on the age-specific prevalence, predictive factors, and prognosis of symptomatic intracranial stenosis in patients with population-based acute cerebral ischemic episodes and mild stroke.
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Two blood factors help with the individualized prognosis treatment of Alzheimer's disease
Time of Update: 2020-12-23
accurate prognostion is important in MCI because it can lead to cognitive decline and dementia (due to AD or other diseases), or benign and stable consequences.
