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BRAIN: Abnormal symposydroid dopamine in schizophrenia is structurally associated with cortical-pausc brain insemination
Time of Update: 2021-01-17
in a system centered on a significant network, the patient's synthesized dopamine synthesis was reduced, which was positively associated with a significant network-central-cerial iFC decrease.
In a system centered on an auditory-sensory motor network, the patient's sensory motor synthesized dopamine synthesis was positively associated with an increase in the auditory-sensory motor network-abdominal cerum iFC.
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Stroke: Depression and diabetes are associated with the onset of dementia after stroke
Time of Update: 2021-01-17
previous studies have shown that stroke patients tend to have worse cognitive impairments when combined with diabetes and depression, but the risk of long-term dementia remains uncertain.
, women with a combination of diabetes and depression had a significantly increased risk of developing LTC and dementia after stroke.
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BRAIN: Cross-frequency coupling of γ and deep brain stimulation frequencies in people with Parkinson's disease
Time of Update: 2021-01-17
It is generally believed that the destruction of pathologically enhanced β oscillation is considered to be one of the key mechanisms to mediate the clinical effects of deep brain stimulation on the motor symptoms of Parkinson's disease.
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Neurology: Chronic brain trauma cell therapy
Time of Update: 2021-01-17
It can be seen that SB623 cell implantation treatment is safer and has good tolerance, and compared with the control group, patients with chronic motor dysfunction secondary to brain trauma (TBI) implantation SB623 treatment improved significantly at 6 months.
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BRAIN: Cerebral amyloid vascular disease: Cortical superficial iron deposition and neuropathological correlation?
Time of Update: 2021-01-17
overall, these data show that cortical superficial tin disease on MRIs corresponds to iron-positive deposits in the shallow epithelial layer, representing a chronic manifestation of soft meningococral hemorrhage attacks.
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Neurology: Xiangya Hospital has found that NfL may be a biomarker of spinal small brain disorders
Time of Update: 2021-01-17
addition, a previous study found elevated serum NfL (sNfL) levels in SCA3 patients, further supporting this hypothesis.
the severity of clinical diseases were assessed using the SARA and Non-Resonance Disorder Signs Scale (INAS).
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BRAIN: The effects of dopamine on intensive learning in Parkinson's disease depend on motor-induced power generation
Time of Update: 2021-01-17
formal modeling showed that dopamine drugs had different computational effects on the ideomorphism of Parkinson's disease, and adjusted the motivational bias and learning rate of non-tremor and tremor patients respectively.
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JAMA Psy: Machine learning identifies risk factors for suicide attempts
Time of Update: 2021-01-17
Using the survey questions in the first interview, the suicide attempt risk model produced a cross-validated subject operator characteristic curve with an area of 0.857, with a sensitivity of 85.3% and a specificity of 73.3% at the optimized threshold.
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Expert interview | Hu Hao: Change the mind, prevent stroke, adhere to standardized operation, for patients to bring better prognostication
Time of Update: 2021-01-16
In recent years, China's structural heart disease field has developed rapidly, in congenital heart disease, left heart ear blocking and other fields have been in the international leading level; rece
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Neurology: Beijing Tiantan Hospital found: intracranial ruptured small aneurysm, aspirin treatment is safe and effective
Time of Update: 2021-01-16
to determine whether a small aneurysm rupture is high risk is key to preventing fatal and disabling intracranial bleeding.
of the study is to find that aspirin is a safe treatment for patients with both small UIAs and ICVD.
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BMJ Sub-Journal: Study of Trauma and Depressive Symptoms in People at High Risk of Dementia in Middle Age
Time of Update: 2021-01-16
use linear and logical models to assess the association between childhood trauma, depression, dementia risk, cognitive test scores, and sea mass volume.
childhood trauma and depressive symptoms were closely related to the decrease in the size of the sea mass, but not to current cognitive function or dementia risk.
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Cell: Continuous progress! Yigong Shi's team uncovered the whole process of combining Alzheimer's important protein gamma secretase with drugs for the first time
Time of Update: 2021-01-16
December 28, 2020, a team from Tsinghua University published a research paper entitled "Structural basis of γ-secretaseion and modulation by small γ drugs" online, which looked at the structural mechanisms of three different GSI inhibitors γ secretion enzymes: S.
study, three different structural mechanisms of GSI γ inhibition of secretion enzymes were reported: Semagacestat, Avagacestat, and L685,458.
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Wake up "plant people" and improve nerve function Beijing Tiantan Hospital neurosurgery consciousness disorder area officially opened
Time of Update: 2021-01-16
The neurosurgery consciousness disorder area of Tiantan Hospital in Beijing mainly carrys out consciousness assessment, diagnosis and prognosis of consciousness disorder, and uses comprehensive treatment methods such as surgery, medicine, neuroconstransitation and brain-machine interface to accelerate and improve the consciousness recovery of DOC patients and maximize the improvement of nerve function.
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BRAIN: Genetic, cellular and connective tissue characteristics of the brain regions common to gliomas?
Time of Update: 2021-01-16
based on previous studies of neuropsycological disorders and cancer, gliomas are expected to be located in brain regions characterized by the transcription of genetic drivers of functional hubs, stem cell-like cells and gliomas.
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Elife: God! Scientists have found that the drug can reverse age-related cognitive decline overnight
Time of Update: 2021-01-16
new study is based on a previous mouse experiment in which researchers found that long-term ISR activity was associated with persistent cognitive and behavioral impairment in patients with traumatic brain injury, and that using ISRIB therapy almost overnight restored normal brain function in mice.
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Nature Neuroscience: Downlink regulation of mechanical sensory hypersensitive reactions by star-shaped glial cells in the shallow spinal cord of the brain
Time of Update: 2021-01-16
HES5 is highly expressed in embryonic neuro prescient cells and is essential for negative regulation of nerve and less protrusion glial cell differentiation.
HES5 is highly expressed in embryonic neuro prescient cells and plays an important negative regulatory role in the differentiation of nerve and less protrusive glial cells.
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Lancet Neurol: Professor Xue Mengzhou, Zhengzhou University, reviewed the mechanisms of secondary injury and protection associated with inflammation after cerebral hemorrhage
Time of Update: 2021-01-16
Recently, Professor Xue Mengzhou, Director of cerebrovascular disease department of Zhengzhou University and director of the Key Laboratory of Cerebral Vascular Disease Translational Medicine in Henan Province, published a paper entitled: Neuroinflammation inintracerebral haemorrhage: immunotherapies with potential for translation in The Lancet Neurology(impact factor 30.039) in the field of neurology.
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JNNP: cerebrospinal fluid β-synuclein as an early diagnostic marker for Alzheimer's disease
Time of Update: 2021-01-16
addition, the findings confirm previous studies that have given mass spectrometry, i.e. increased levels of β-synuclein in CSF in AD and CJD patients, supporting its potential use as a synapse degeneration marker.
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Nat Neurosci: Immune cells accelerate normal brain aging
Time of Update: 2021-01-16
In addition, evidence such as RNA sequencing and immunosequencing suggests that aging causes the main tissue-compatible complex Class I molecule (MHC-I) on the surface of neuro preamble cells to be reduced, resulting in a loss of immune tolerance, thereby activating immunosuppression during normal brain aging and damaging nerve precipitate cells (Figure I).
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AXS-07 achieved positive results in Phase III trials of migraine therapy
Time of Update: 2021-01-16
Biologics company Axsome Therapeutics announced today that the AXS-07 Long-Term Open Phase III Trial (MOVEMENT Study) has yielded positive results.
results showed that AXS-07 provided lasting relief from migraines, with 24 percent of patients not using first aid drugs within 24 hours and 83 percent not using first aid drugs within 48 hours.
