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JNNP: Olfactory impairment as an early sign of Parkinson's disease in rapid eye movement sleep behavior disorders: systematic review and meta-analysis
Time of Update: 2021-01-22
This paper provides a systematic review and comprehensive meta-analysis of existing studies to explore the significance of olfactory function in the diagnosis and prognosis (risk of transition to PD) in RBD patients, and to evaluate the regulatory factors that affect olfactory function.
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JAMA: Treatment of patients with acute large vascular thrombosis stroke - thrombosis joint hydrants vs simple mechanical thrombosis (SKIP study)
Time of Update: 2021-01-22
recently conducted a large-scale non-inferior control study to examine the effects of simple thrombosis and venous thrombosis combined mechanical hydrants on patient prognosis.
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JAMA: Effect of in-vascular therapy on the 90-day functional prognosis of pre-circulating large vascular thrombosis stroke patients after in vitro therapy vs thrombosis
Time of Update: 2021-01-22
the study concluded that for patients with ischemic stroke caused by near-end pre-circulatory cysts within 4.5 hours of onset, the 90-day functional prognosis independent rate achieved by intravascular therapy alone was comparable to that of combined therapy.
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Nat Commun: Key neurons regulate the brain's spatial map
Time of Update: 2021-01-22
they found that not only was the spatial map fish unstable, but the precise time between the launches of grid cells was also affected when the neural networks around the nerves were removed.
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Alnylam under-skin injection RNAi therapy Phase 3 clinical trial results were positive
Time of Update: 2021-01-21
announced today that it is working on RNAi therapy vutrisiran, which reaches the primary and secondary endpoints after nine months in Phase 3 clinical trials for patients with hereditary thyroxine protein (hATTR) amyloid degeneration.
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Qilu Pharmaceuticals " O nitrogen flat mouth solution film" is about to be approved for the market
Time of Update: 2021-01-21
Source: Pharmaceutical Rubik's Cube Info recently, Qilu Pharmaceuticals according to the chemical drug class 2.2 declared O nitrogen flat-mouth soluble film application (acceptance number: JXHS1800028, CXHS1900029) in the "in the approval" stage, is expected to be approved by NMPA in the near future.
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Stem cells promise to revolutionn traditional heart surgery!
Time of Update: 2021-01-21
a wealth of evidence from preclinical animal studies and clinical trials suggests that interstitial or mixed bone marrow stem cell groups injected into coronary arteries may be a simple and effective treatment for heart disease.
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Highlights to be read in the December 2020 issue of Science
Time of Update: 2021-01-21
4.Science: Using a gene interaction map to determine the overall structure of the protein complex doi:10.1126/science.aaz4910; Doi:10.1126/science.abf3863 Now, in a new study, researchers from the Gladston Institute in the United States and the University of California, San Francisco, have confirmed that a large-scale systematic genetic method does provide reliable and detailed information about the structure of protein complexes.
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2020 How exactly does AI in the Internet plus Medical Segments misdiagnose?
Time of Update: 2021-01-21
all the apps included in the evaluation have artificial intelligence sub-diagnosis function, which mainly takes the form of "providing information matching misdiagnosis" and "sub-diagnosis through user selection options".
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2020 Final Count: Life Sciences Breakthrough Award Interpretation
Time of Update: 2021-01-20
Professor David Baker of the Howard Hughes Institute of Medicine (HHMI) at the University of Washington, in recognition of his innovative work in protein design and synthesis; Professor Chinese Ming Dennis Lo, of Chinese University of Hong Kong, recognises the discovery of fetal DNA in the mother, thereby facilitating prenatal screening to avoid the birth of deformed fetuses, and Professor Richard J.
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Advances in photogenetics research in 2020 and their prospects
Time of Update: 2021-01-20
photogenetic technology has two characteristics of unique high space-time resolution and cell type specificity, overcomes many shortcomings of traditional means to control cell or organism activity, can carry out non-invasive precision positioning stimulation of neurons and completely changed the research situation in the field of neuroscience, providing a revolutionary research method for neuroscience.
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New drug for nerve pain after shingles! New powerful AAK1 inhibitor LX9211 enters Phase II clinical: penetration of the nervous system, no risk of addiction!
Time of Update: 2021-01-20
RELIEF-PHN-1 is a randomized, double-blind, placebo-controlled, parallel group, multi-center Phase 2 study that is evaluating the efficacy, safety, and pharmacodynamics of LX9211 for the treatment of post-shingles nerve pain (PHN).
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2020 Final Count: MacArthur Genius Award Interpretation
Time of Update: 2021-01-20
Damien Fair has won the MacArthur Genius Award 2020 for designing network connectivity maps in the brain to deepen our understanding of how different regions communicate and develop in typical and atypical situations.
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Nature: New discovery! Pain nerves may help regulate the mobilization of the body's hematopoietic stem cells!
Time of Update: 2021-01-20
JANUARY 4, 2021 // -- In a recent study published in the international journal Nature, scientists from the Albert Einstein College of Medicine and others found that pain nerves in the body's bone marrow may help regulate the mobilization of hematopoietic stem cells.
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Nature: Astrocytes may devour synactical connections to maintain the plasticity of the adult body's brain
Time of Update: 2021-01-20
Professor Won-Suk Chung, an researcher, said the study had far-reaching implications for understanding the molecular mechanisms of changes in the brain's neural circuits during learning, memory and even illness, and that changes in the number of synapses were highly correlated with the prevalence of a variety of neurological disorders, such as autism spectrum disorders, schizophrenia, frontal lobe dementia and multiple forms of epilepsy.
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Mol Neuro: A new treatment for depression
Time of Update: 2021-01-20
" team tested the hypothesis that stress response increases methylation of the BDNF gene, thereby reducing its expression, and that this decrease is associated with depressive behavior.
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New drug for acute treatment of migraines! Axsome's new oral multi-mechanism drug AXS-07 Phase III Clinical: Fast and effective long-lasting migraine relief!
Time of Update: 2021-01-20
, the company announced positive results for evaluating its new oral multi-mechanism drug AXS-07 for the long-term open-label Phase 3 MOVEMENT test for acute migraine treatment.
" MOVEMENT is an open label Phase 3 trial designed to assess the long-term safety of AXS-07 in patients with migraine attacks for up to 12 months.
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New antipsychotic drugs! ALKS3831 (Otspin/samidorphan) has been re-accepted by the FDA: Treatment of Schizophrenia/Biphasy Type I Disorder
Time of Update: 2021-01-20
ENLIGHTEN-1 is a 4-week randomized, double-blind Phase III study conducted in patients with schizophrenia who are experiencing acute exacerbation, comparing the antipsychotic efficacy, safety and tolerance of APKS3831 relative to placebo.
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Brain Circul: Scientists have developed a new strategy for treating stroke
Time of Update: 2021-01-20
researcher Nicolas Bazan says that using experimental models may help develop new therapeutic strategies for treating isothermic strokes, where special signals are produced by primary brain immune cells that reach white blood cells and are called small glial cells, which can cause neuroinflamm, leading to the accumulation of chemicals that damage the brain, and the accumulation of plate plate activators (PAFs), which play a key role in neuron survival.
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End of 2020: Interpretation of important research results in the field of Alzheimer's disease!
Time of Update: 2021-01-20
Previous studies have shown that one of the risk factors involved in alzheimer's disease is the accumulation of β-amyloid proteins in brain cells, and that some people carry mutations in the body called A673T, compared to the general population.
