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Neurology: Patients with tumor brain metastasis may consider using epilepsy drugs to reduce the risk of seizures
Time of Update: 2021-01-25
In the tissue queue, melanoma and non-small cell lung cancer (HR=1.70), diagnosis greater than 4 BrM (HR=1.60), presence of BrM (HR=3.62) in high-risk locations, and lack of local brain-oriented therapy (HR=3.08) were associated with a greater risk of seizure development.
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JAMA Sub-Journal: Neurological outcome prediction of simple venous thrombosis therapy in patients with small stroke combined with large vascular thrombosis
Time of Update: 2021-01-25
, the study aims to develop and validate an ENDi prediction score that is easy to apply to patients with small stroke combined with LVO venous thrombosis.
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Annals of Neurology: The Mendel randomization study reveals that apoB is the ecaused by ischemic stroke
Time of Update: 2021-01-25
studies have shown that high levels of low-density lipoprotein (LDL) cholesterol increase the risk of ischemic stroke, while high levels of high-density lipoprotein (HDL) cholesterol may reduce the risk of ischemic stroke, especially small blood vessel stroke.
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JNNP: Effect of Erenumab on functional outcomes in patients with seizure migraines
Time of Update: 2021-01-25
the purpose of this analysis was to evaluate the functional results reported by patients with the efficacy of Erenumab and placebo in patients who were ineffective with 2-4 preventive drugs in the Phase 3b LIBERTY study.
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Annals of Neurology: Patients with high levels of NfL after surgery are more likely to develop delirium
Time of Update: 2021-01-25
Neuron-specific oleolase (NSE) is a highly specific marker of neurons and exocyte endocrine cells with different results, with one study showing lower NSE levels in cerebrospinal fluid (CSF) in patients with delirium, others reporting higher plasma NSE concentrations, and some studies have found no significant differences between delirium and control groups.
NfL increase in PO1MO is associated with delirium and greater cognitive decline.
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Neurology: fMRI functional connectivity to predict long-term cognitive outcomes after stroke
Time of Update: 2021-01-25
machine learning algorithms can start with patient-level observations and look for a combination of features that can reliably predict results; , Renaud Lopes of the University of Lille in France and others have looked at whether FUNCTIONAL Connectivity can predict long-term cognitive function 36 months after a mild stroke.
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How much exercise is best?
Time of Update: 2021-01-25
subjects with higher MVPA in middle age were less likely to have cavity infarction (OR: 0.68, 95% CI:0.46, 0.99), lower chance of cortique infarction or underthelecture in old age, white matter microstructure is also more complete A prospective analysis of leisure-time physical activity in mid-life and brain damage on MRI in older adults.
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JNNP: Cerebrospinal fluid β-synactin can be used as an early diagnostic indicator of Alzheimer's disease
Time of Update: 2021-01-25
For Alzheimer's disease (AD), the testing of tau protein and amyloid β peptide (A beta 42) in cerebrospinal fluid (CSF) has been successfully applied to current diagnostic standards and clinical applications, but neither tau as a general marker of neurodegenerative degeneration nor a beta 42 as a marker of amyloid protein deposition can reflect degenerative changes in AD.
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JAMA Neurol: The latest evidence on the clinical manifestations and therapeutic characteristics of spontaneous low craniofacial pressure
Time of Update: 2021-01-25
Spontaneous intracranial low pressure (SIH) defines a clinical symptom characterized by a debilitating positional headache that occurs from spontaneous spinal cord fluid (CSF) leakage and/or CSF hypotension.
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Stroke: The course and cognition of delirium after stroke
Time of Update: 2021-01-25
researchers used delirium care scales and delirium rapid assessment methods to conduct two PSD screenings per day and to conduct non-poor evaluations with the standards of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders.
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JNNP: Family clustering effect in genetic screening of 235 French ALS families
Time of Update: 2021-01-25
next-generation sequencing (NGS) analysis with all pre-emptors to study the following genomes: ALS2, ANG, CHCHD10, CHMP2B, DAO, DCTN1, DPYSL3, FIG4, FUS, GRN, MAPT, MATR3, NEF H, OPTN, PRPH, PSEN1, PSEN2, SETX, SIGMAR1, SOD1, SPG11, QSTM1, TAF15, TARDBP, TBK1, TREM2, TUBA4A, UBQLN2, VAPB and VCP.
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Stroke: Relationship between body mass index and clinical outcomes in patients with atrial fibrillation treated with oral anticoagulant therapy
Time of Update: 2021-01-24
higher BMI (5 kg/m2 per increase) and ischemic stroke (risk ratio of 0.891 (95% CI 0.801-0.992)), gastrointestinal bleeding Hospitalization (HR is 0.785 (95% CI is 0.658-0.937) and haemorrhage (HR is 0.794 (95% CI is 0.686-95% CI) 0.919), all-cause death (HR is 0.658 (95% CI is 0.605-0.716) and comprehensive clinical outcome (HR is 0.751 %CI is 0.706-0.799) with a lower risk correlation, with the exception of intracranial bleeding (HR is 0.815 (95% CI is 0.627-1.061).
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JAHA: Relationship between anxiety and pain medication and risk of post-traumatic stress disorder symptoms in patients with acute coronary syndrome
Time of Update: 2021-01-24
adjustment of all covariates, the use of benzodiazepines was significantly related to the overall severity score of the clinician-administered PTSD scale (non-standardized coefficient B (SE) was 0.589 (0.274); the symptoms of acute stress disorder, the relative risk of clinical PTSD in patients exposed to benzodiazepines increased nearly fourfold (ratio ratio was 3.75; 95% confidence interval was 1.31-10.77).
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The Harvard study found that Tau protein affects cognitive function differently between men and women
Time of Update: 2021-01-24
, there have been few reports of results from tau-positive electron emission fault scanning (PET) to explore the gender differences in the distribution of tau signal brains.
ROI, women with higher tau signals showed faster cognitive decline than men (P s 0.04).
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Acta Neuropathologica: Mitochondrial bioeneral energy defects in C9orf72 amyotrophic lateral sclerosis motor neurons lead to axon stabilization disorders
Time of Update: 2021-01-24
Compared with astrocytes, neurons rely mainly on mitochondrial oxidation phosphate, plus extra-long MN axons, which are 20,000 times longer than their cystic diameters, indicating that MN is particularly prone to metabolic defects in the critical process of maintaining the form and function of axons: axon steady-state dysfunction.
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis.
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Stroke: Hemorrhage in children with cerebral hemorrhage is enlarged
Time of Update: 2021-01-24
researchers assessed clinical outcomes at 12 months using King's Children's Head Injury Outcome Scale and defined a score of ≥5 for better outcomes.
was independently associated with poor prognosmation (King's Children's Brain Injury Outcome Scale s.lt;5A, with a ratio of 5.77 (95% CI of 1.01-38.95) ;P=0.043).
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JNNP: Myelin less protrusion glial cell glycoprotein antibody-related diseases, optic neurospinal cord disease spectrum disorders in the brain thymus and cer cerebral injury comparison
Time of Update: 2021-01-24
study, we attempted to determine the frequency, associated symptoms and signs of cerebral and cer cerebral injury in MOGAD, laboratory and MRI characteristics, and their differences from AQP4 IgG NMOSD and MS.
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JNNP: Brain magnetic resonance diagnosis of MOG antibody-related diseases and AQP4 antibody-related diseases
Time of Update: 2021-01-24
in pediatric patients, cer cerebral foot lesions are the majority in MOGAD, but there is no statistically significant difference between brain bridge, pausc and cortical lesions.
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JAMA Psychiatry: Are elevated insulin levels and BMI trends associated with depression and psychosis in adulthood?
Time of Update: 2021-01-24
A new study published recently in JAMA Psychiatry explores these issues, using data from alSPAC birth queues to analyze (1) the longitudinal trajectory of FI levels and BMI based on repeated measurements of individuals aged 1-24, (2) the characteristics of the identified trajectories, and (3) the correlation between mental illness and depression risk at age 24 by sex in the total sample.
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JNNP: Olfactory impairment as an early sign of Parkinson's disease in rapid eye movement sleep behavior disorders: systematic review and meta-analysis
Time of Update: 2021-01-22
This paper provides a systematic review and comprehensive meta-analysis of existing studies to explore the significance of olfactory function in the diagnosis and prognosis (risk of transition to PD) in RBD patients, and to evaluate the regulatory factors that affect olfactory function.
