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JNNP: The significance of gene screening for amyotrophic lateral sclerosis system
Time of Update: 2021-02-26
Currently, at least in the UK, only cases with a family history of ALS, dementia or a younger age tend to routinely screen for genes in a clinical setting, and with the emergence of specific genetic forms of treatment for diseases associated with SOD1 or C9orf72 mutations, this raises the question of whether all ALS patients should be genetically screened.
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Science: Changes in a single gene distinguish modern humans from Neanderthals?
Time of Update: 2021-02-26
To answer this question, Muotri's team used CRISPR gene editing techniques to edit stem cells from modern humans, introducing mutations in the Neanderthal NOVA1 gene that simulate "Neanderthalized" brain organs.
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The study found that the intensity of synactic pulses is directly related to the size of synapses
Time of Update: 2021-02-26
allows researchers to artificially activate one nerve cell while measuring the intensity of synapse pulses produced by the other.
because synapses are so small, researchers use high-resolution electron microscopes to reliably identify and accurately measure the contact points of neurons.
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Do you remember what happened last night? 48% of drinkers have had alcohol amnesia before the age of 19!
Time of Update: 2021-02-26
Young people with increasing amnesia are 2.5 times more likely to develop severe alcohol problems in early adulthood, including alcohol abuse and dependence, and for the study, researchers recruited 1,821 13-year-olds from Year 7 classes in New South Wales, Western Australia and Tasmania in 2011-2012 and asked them to complete an annual alcohol-related questionnaire.
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Scientists have found a promising new treatment for Parkinson's disease
Time of Update: 2021-02-26
Researchers from Israel's Ben Gurion University (BGU) have found that protein BMP5/7 promises to provide a new approach to the treatment of Parkinson's disease, which is expected to slow or stop the progression of the disease, according to a recent study published in Brain.
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JACC: Relationship between middle-term subclinical atherosclerosis and brain metabolism and cognitive function
Time of Update: 2021-02-26
CVD risk factors, including high blood pressure, diabetes, high cholesterol levels, sedentary lifestyles and smoking, can affect glucose intake and metabolism in the brain in older adults, according to a study.
: Subclinical Atherosclerosis and Brain Metabolism in Middle-Individuals: The PESA Study.
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IkT-148009 treats Parkinson's, phase I clinical trials have officially begun
Time of Update: 2021-02-26
IkT-148009 is an Abelson non-subject tyrosine kinase (c-Abl) inhibitor used to treat Parkinson's.
, Chief Executive Officer of Inhibikase Therapeutics, said: "The launch of the Phase I study on the treatment of Parkinson's disease by IkT-148009 represents an important milestone for Inhibik Therapeutics.
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JNNP: Prediction of independent mortality in patients with frontal temporal degenerative syndrome
Time of Update: 2021-02-26
a cross-diagnostic survival method was used in an epidemiological cohort in the UNITED Kingdom to test clinically diagnosed behavioral variability pretentiac dementia (bvFTD n=64), non-fluent variability primary regenerative adaffle (nfvPPA n=36) The relationship between clinical characteristics, independence, and survival rates in patients, semantic variant primary progenitic aphdplia (svPPA n=25), regenerative nuclear paralysis (PSP n=101) and cortical substrate artery syndrome (CBS n=68).
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The essence of the February 12, 2021 issue of Science
Time of Update: 2021-02-26
Embedded nanoparticles can produce a cross-immune response to a range of coronavirus, and it is expected that the development of a universal coronavirus vaccine doi:10.1126/science.abf6840 causes a pandemic of SARS-CoV-2 virus is just one of many different viruses in the coronavirus family.
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JACC: Study reveals early link between brain metabolism and cardiovascular risk
Time of Update: 2021-02-26
The CNIC-coordinated study, led by Dr. Marta Cortés Canteli, showed that atherosclerosis and cardiovascular risk factors had been shown to be associated with low metabolism in the brain region in middle age, years before any clinical signs appeared, which was associated with future development of dementia, particularly Alzheimer's disease.
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JAMA Psython: How different are the individuals in antidepressant therapy?
Time of Update: 2021-02-26
used primarily to assess whether individual differences in drug use between groups were related to the severity of baseline depression, the type of antidepressant use, and the year of the study.
Individual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials.
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Eur Radiol: The risk of rupture of intracranial aneurysms is predicted by radiology!
Time of Update: 2021-02-25
5 morphological features and 89 radiological features were significantly associated with aneurysm rupture.
use of radiological features, especially texture characteristics, can significantly improve the performance of predicting aneurysm rupture.
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JAHA: Computer fault scans for the best cervical arterial plaque characteristics associated with ischemic stroke in angiology
Time of Update: 2021-02-25
the final differentiation value (area 78.3% between curves) is higher than in-cavity thrombosis (56.4%, P.lt;0.001), maximum soft spot thickness (76.4%, P-0.007), or only rim signs (69.9%, P-0.001).
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JAHA: Analysis of the outcome of antiplate plate platea-related cerebral hemorrhage
Time of Update: 2021-02-25
Antiplate plate plate therapy increases the risk of hematoma expansion in patients with cerebral hemorrhage (ICH), and the effect on the patient's functional prognosis is not yet clear.
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Acta Neuropathologica: Proteomics study of empty bubble degeneration of Alzheimer's particles and entanglement of neurogenic fibers
Time of Update: 2021-02-25
In addition to amyloid plaques and neurogenic fiber tangles (NFTs), the pathological characteristics of Alzheimer's disease (AD) are usually neurons with particle empty bubble degeneration (GVD).
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JAHA: Treatment trends in patients with ruptured and unbromed aneurysms in the United States
Time of Update: 2021-02-25
researchers performed polynotial regression to calculate the relative risk ratio of treatment for ruptured or unbromed aneurysm patients compared to the reference control group, and time-adjusted.
result, the relative risk ratio of aSAH treatment was significantly reduced over time, while the risk of treatment for patients with unbromed intracranial aneurysms was stable.
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Cerebral Cortex: Regular caffeine intake may affect brain structure
Time of Update: 2021-02-25
10 days after taking the placebo - known as "caffeine withdrawal" - the volume of gray matter was larger than during the same period of taking caffeine capsules.
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JAMA Netw Open: Insomnia? Then fight tai chi
Time of Update: 2021-02-25
compared with the control group, the treatment response rate was higher in the post-intervention and follow-up sports group and tai chi group, and there was no significant difference between the exercise group and tai chi group during the two evaluations.
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Eur Radiol: What is the value of the APT sequence in evaluating ALS patients?
Time of Update: 2021-02-25
recently, a study published in the Journal of European Radiology assessed changes in alamide concentration in ALS patients compared to healthy control groups using quantitative APT and multiparamer magnetic resonance imaging, and tested their relevance to clinical scores, providing a new reference for early diagnosis of ALS.
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Flower season girls swallow 30 pills a day, more than ten years dare not go out, just because... In the end, a few small electrodes saved her
Time of Update: 2021-02-25
There are all kinds of pain in this world is painful, compassionate but some of the pain has been "stigmatized" patients unfair treatment, and even discrimination against epilepsy is one of them in th
