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Neuromodulation: Long-term efficacy of transcranial direct current stimulation in preventing paroxysmal migraine: results of a randomized controlled trial
Time of Update: 2021-07-27
Compared with sham stimulation, anode tDCS can lead to long-term reduction of migraine days in patients with EM .
Compared with sham stimulation, anode tDCS can lead to long-term reduction of migraine days in patients with EM .
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Nat Commun: EWASplus, a machine learning method for epigenetic analysis, reveals genes related to Alzheimer's disease
Time of Update: 2021-07-27
Multiple array-based whole epigenome association studies (EWAS) have identified strong brain methylation changes in AD; however, array-based detection can only detect about 2% of all CpG sites in the genome .
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Nutritional Neuroscience: Too much coffee will reduce brain capacity and increase the risk of dementia by 50%!
Time of Update: 2021-07-27
Higher coffee consumption is significantly associated with a decrease in brain capacity-basically, drinking more than 6 cups of coffee a day may put you at risk for brain diseases such as dementia and stroke .
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JAMA Sub-Journal: Severe injury in a short period of time does not mean a poor prognosis for moderate to severe traumatic brain injury
Time of Update: 2021-07-27
references:Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study.
2043Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study.
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CELL: Reactivation of CaMKII can protect optic nerve cells to prevent vision loss from glaucoma
Time of Update: 2021-07-27
Similarly, in glaucoma models based on elevated intraocular pressure or genetic defects, gene therapy to increase CaMKII activity proved to have a protective effect on retinal ganglion cells .
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JAMA Neurology-system screens tens of thousands of children's brain magnetic resonance, what are the unexpected findings?
Time of Update: 2021-07-27
The important significance of this large-scale children's study is that the accidental findings of brain MRI and discoveries with potential clinical significance are common in the general pediatric population .
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JAMA Neurology-How is the functional recovery within one year after brain injury?
Time of Update: 2021-07-27
Patients with msTBI often show major functional benefits from 2 weeks to 12 months after injury, including regaining independence .
Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study.
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HUMAN BRAIN MAPPING: How high your pain point is, the insular cortex decides
Time of Update: 2021-07-27
used voxel-based morphometrics (VBM) and graph theory, especially the local clustering coefficient (CC) based on resting state functional connection, To identify brain regions, where the volume of regional gray matter and network characteristics predict individual pain thresholds .
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Ann Neurol.-Zhejiang University of Traditional Chinese Medicine New Discovery: Anti-epileptic Therapy, New Mechanism of Drug Resistance
Time of Update: 2021-07-27
These results support the hypothesis that the Caspase-1-interleukin-1β inflammatory pathway under the cell membrane is a new alternative mechanism for drug-resistant TLE , and suggest that Caspase-1 is a potential target .
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JAMA Sub-Journal: Is ticagrelor combined with "magic drug" aspirin more effective in the treatment of patients with stroke
Time of Update: 2021-07-27
StrokeBased on these studies, current guidelines recommend early and short-term (21 days) combined treatment of clopidogrel and aspirin for high-risk TIA and mild non-cardiac ischemic stroke patients with NIHSS scores of 3 or less .
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Neurology-new mechanism: why patients with migraine are prone to dizziness
Time of Update: 2021-07-27
Our goal is to evaluate the clinical and brain responses of migraine patients and control groups using computer-programmed visual self-motor stimuli to simulate a roller coaster .
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JACC: A new treatment option for atrial fibrillation-predictors of device-related thrombosis after percutaneous left atrial appendage occlusion
Time of Update: 2021-07-27
Currently, internal medicine percutaneous left atrial appendage occlusion (LAAO) is a safe and effective method that can replace anticoagulants to prevent stroke and systemic embolism in patients with atrial fibrillation .
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JAMA Neurology-Intravascular thrombectomy, the faster the better, the better the prognosis
Time of Update: 2021-07-27
In addition, for patients with LVO transferred to hospital, whether the value of repeated angiography is different between patients in the early (0-6 hours) and late (>6-24 hours) treatment window, or whether it is based on the imaging from the non-EVT center to the arrival at the EVT center The length of time is also unknown .
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Ann Neurol-Early onset vs. late onset myasthenia gravis, what is the difference in genomics?
Time of Update: 2021-07-27
Recently, Lahiru Handunnetthi and others of the University of Oxford developed Priority Index, a genomics method that combines cell-type-specific functional genomic information, such as gene expression and chromatin organization, with the findings of GWAS to determine disease-related Gene .
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NEJM: Pimaserin is effective for dementia and psychosis caused by many reasons
Time of Update: 2021-07-27
Vascular FDA researchers recently investigated the effects of pimaserin on the psychiatric symptoms of patients with dementia of various causes .
Pimaserin has a good therapeutic effect on dementia-related psychosis caused by various diseases.
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JAMA Neurology-PET detection of Tau protein predicts cognitive decline, which is better than conventional indicators
Time of Update: 2021-07-27
(2) Perform head-to-head comparisons of Tau PET with established magnetic resonance imaging (MRI) and amyloid PET markers to predict future cognitive changes;(3) Investigate whether age, gender and/or APOE genotype will change the association between baseline Tau PET and cognitive changes .
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BMJ: Relax-how does the lipid-lowering drug statin perform in primary prevention of cardiovascular disease?
Time of Update: 2021-07-27
However, recent guidelines recommend the wider use of statins in primary prevention, so that a large number of low-risk CVD populations are eligible for treatment and face the risk of adverse reactions .
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JAMA Sub-Journal: The relationship between APOEɛ4 allele and adults with dementia caused by Down syndrome
Time of Update: 2021-07-27
In order to study the relationship between APOEɛ4 alleles and clinical and multimodal biomarkers in adult DS patients, JAMA Neurology recently published related studies .
1893Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome.
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JAMA Neurology-Intensive blood pressure therapy, with limited impact on the outcome changes in the brain
Time of Update: 2021-07-27
Both ACCORD and SPRINT showed that compared with standard treatment, the total brain volume (TBV) of intensive treatment had a small but statistically significant decrease, although it is not clear to what extent these differences reflect atrophy and hydration status.
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JAMA Neurology-After 20 years of follow-up, it was found that the overall disability rate of children with multiple sclerosis gradually decreased
Time of Update: 2021-07-27
diagnosisSo far, in adults with multiple sclerosis, the risk of reaching persistent disability has gradually decreased over time; however, this finding has not been confirmed in the POMS population, and their management is subject to DMTs approved before the age of 18.
