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JAMA Sub-Journal: Why did the FDA accelerate the approval of Aducanumab, a new drug for Alzheimer's disease?
Time of Update: 2021-08-03
S. Food and Drug Administration (FDA) approved Adunazumab (Aduhelm), the first new drug to treat Alzheimer's disease in 20 years .
The reason for the accelerated approval is to provide drugs for the treatment of serious diseases as soon as possible when the final clinical benefits of the drugs are still uncertain at the time of approval .
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Alzheimer & Dementia: A head-to-head comparison of the clinical diagnosis of p-tauT181 and T217 in the cerebrospinal fluid of AD patients
Time of Update: 2021-08-03
Aβ pathology is the earliest detectable change in AD, and the established p-tau181 becomes abnormal in the late stage of mild cognitive impairment (MCI) and dementia .
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HBP: Machine learning uses high-level functional connections to distinguish between type 2 diabetes and healthy people with or without cognitive impairment
Time of Update: 2021-08-03
Differentiating performance between T2DM-CI and HC and T2DM-noCI and HCDifferentiating performance between T2DM-CI and HC and T2DM-noCI and HCThe left panel shows the first two higher-order functional connections based on discriminative dynamics selected from the classification between type 2 diabetes with cognitive impairment (T2DM-CI) and healthy controls (HC) according to the frequency of selection (95.
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Brain’s new discovery: people with migraine are three times more likely to get depression than ordinary people?
Time of Update: 2021-08-03
In order to better determine the degree of overlap between the polygene structure of migraine and bipolar disorder, depression and schizophrenia beyond the genetic correlation, and to determine the shared gene locus, led by a psychiatric specialist from Oslo University Hospital, Norway A study was carried out and the results were published in the latest "Brain" magazine .
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Radiology: Application of STAIR-UTE MRI sequence in myelin imaging
Time of Update: 2021-08-03
Recently, a study published in the journal Radiology explored the feasibility of using the STAIR-UTE sequence under 3T MRI to image ultrashort T2 myelin protons in the white matter of healthy volunteers and multiple sclerosis (MS) patients, and compared MS The myelin content measured by UTE in patients and health volunteers proves its clinical value, and provides a more accurate and direct imaging method for clinical evaluation of demyelinating lesions .
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Radiology: A new perspective on neuromyelitis optica spectrum diseases: from imaging to clinical
Time of Update: 2021-08-03
This study shows that in optic neuromyelitis spectrum diseases, myelopathy is mainly distributed in the upper cervical spinal cord and gray matter on MRI, and is related to spinal cord atrophy and clinical disability.
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Ir J Med Sci: Nursing programs based on reminiscence therapy can alleviate post-stroke cognitive impairment, anxiety and depression in patients with acute ischemic stroke
Time of Update: 2021-08-03
In a randomized controlled study, researchers evaluated the benefits of the Reminiscence Therapy-Based Care (RTBC) program in recovering cognitive impairment, reducing anxiety and depression in patients with AIS.
, Reminiscence therapy-based care program relieves post-stroke cognitive impairment, anxiety, and depression in acute ischemic stroke patients: a randomized, controlled study .
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International Journal of Clinical and Health Psychology: Some post-COVID-19 neurological syndrome symptoms may scare yourself
Time of Update: 2021-08-03
However, the key finding of this study is the impact of the diagnostic threat; exposure to PCNS-related information can increase self-reported symptoms of cognitive dysfunction, but only in COVID-19 patients .
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Ann Neurol-Cerebrospinal fluid bone marrow microvesicles can effectively predict the prognosis of multiple sclerosis
Time of Update: 2021-08-03
This study confirmed that CSF bone marrow microvesicles are a clinically significant biomarker of neuroinflammation and microglia/macrophage activity in the body .
CSF bone marrow microvesicles are a clinically significant biomarker of neuroinflammation and microglia/macrophage activity in the body .
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JNNP-For patients with visual abnormalities, non-invasive local cerebral blood flow monitoring explains its mechanism
Time of Update: 2021-08-03
In addition, compared with the control group, during visual stimulation, the rCBF of the right cerebral cortex of VSS subjects increased, reflecting greater changes related to the task.
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IEEE trans: Study on effective brain connectivity of Ld-EEG in patients with tidal breathing
Time of Update: 2021-08-03
This article analyzes the EEG clinical records of patients with HF and CSR to assess the impact of CO 2 changes caused by the CSR cycle at the cortical level , and evaluates the classic EEG frequency bands of cortex-cortical interactions during CSR in patients with systolic heart failure (ie, δ, θ, α, β, low γ) significant difference in RPDC value .
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PLoS Genet: The cerebellum plays an important role in the evolution of the human brain
Time of Update: 2021-08-03
Many studies on human-specific changes in gene expression and epigenetic markers have focused on the prefrontal cortex, but increasing understanding of the role of the cerebellum in cognition and motor processing has stimulated considerable new research .
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Radiology: The relationship between brain white matter hyperintensity and neural networks and cognitive functions
Time of Update: 2021-08-03
≥This study was made now cerebral white matter high signal (WMH) volume, the local information processing speed and efficiency of the network is interrelated score .
This study was made now cerebral white matter high signal (WMH) volume, the local information processing speed and efficiency of the network is interrelated score .
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Lancet Neurology-After intracerebral hemorrhage, whether it recurs depends on what factors?
Time of Update: 2021-08-03
Therefore, Linxin Li of the University of Oxford and others analyzed two contemporary prospective, population-based cohort studies in the UK to resolve three uncertainties: First, among unselected ICH patients, according to ICH location and combined AF Stratification, the absolute and relative risks of recurrence of ICH and ischemic stroke; second, the risk of all serious vascular events after ICH; and third, the prevalence of RESTART .
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JNNP: Axon orientation dispersion and density imaging reveals early changes in normal white matter in children with multiple sclerosis
Time of Update: 2021-08-03
Using nonparametric multivariate analysis of variance, including age and gender as covariates, the NODDI measurement values of HC and pedMS in NAWM in different brain regions were compared .
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HBP: Learning a foreign language does not affect brain arithmetic activities
Time of Update: 2021-08-03
used functional magnetic resonance imaging to compare the brain activity of 44 English monolinguals and 44 Spanish-English early bilinguals when solving arithmetic problems in English .
used functional magnetic resonance imaging to compare the brain activity of 44 English monolinguals and 44 Spanish-English early bilinguals when solving arithmetic problems in English .
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HBP: Each sweeping the snow before the door, cognitive task training will not improve other behavioral levels
Time of Update: 2021-08-03
In terms of behavior, participants trained on the spatial working memory task improved over time on the task, but did not improve on the spatial span cognitive similarity test or the grammatical reasoning cognitive difference test .
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Nat Commun: Gene editing during pregnancy to treat fatal childhood lysosomal storage disease
Time of Update: 2021-08-03
In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease.
In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease.
Nature Communications In utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease.
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Progress in Metz Neurology (Issue 008)
Time of Update: 2021-08-02
Science: Scientists have discovered a new type of memory cells in the brain 3,Recently, a new study published in the journal Science showed that there is a type of neurons in the temporal poles of the brain that connect facial perception with long-term memory .
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IEEE trans: Evaluation of upper limb function in Friedreich's ataxia patients through self-feeding activities
Time of Update: 2021-08-02
The upper limb function of FRDA is evaluated by clinical scales of disease severity, such as the Friedreich Ataxia Rating Scale (FARS), the nine-hole column test (9HPT), and the block test (BBT) .
