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Cell first observed phase precession in the human brain: the basic code for negotiating between humans and the environment
Time of Update: 2021-08-16
By recording the activity of a single neuron of the patient during spatial navigation, the author identified non-spatially tuned neurons in the human hippocampus and entorhinal cortex The phase precession .
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Wang Xiangting's group reveals a new mechanism of nervous system gene transcription regulation mediated by long non-coding RNA alternative splicing isoforms
Time of Update: 2021-08-16
On the basis of the preliminary work of the research group, on June 10, 2021, Wang Xiangting's research group published a titled Long non-coding RNA PM maintains cerebellar synaptic integrity and Cbln1 activation via Pax6/Mll1-mediated H3K4me3 on PLOS Biology and published it in the journal The official website is highly recommended [5].
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Mov Disord: What are the changes in the brain structure at different stages of Parkinson's?
Time of Update: 2021-08-14
Laansma, MSc and others of the University of Amsterdam, in the largest study on PD brain morphology (ENIGMA) so far, explored the regional cortical thickness and cortical surface area between PD patients and healthy control subjects.
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JNNP: Cost-effectiveness analysis of screening neonatal spinal muscular atrophy with disease-modified therapy
Time of Update: 2021-08-14
A directed graph representation of the health state modeled in the Markov modelIn the NBS intervention cohort, two disease-modifying treatment options, namely nusinersen or gene therapy, were modeled to obtain the cost and outcome of the SMA patients screened .
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PNAS: Staying up late will increase inhibitory neuron activity and destroy human memory
Time of Update: 2021-08-14
On August 5, 2021, researchers from the University of Michigan in the United States published a research paper titled Sleep loss drives acetylcholine- and somatostatin interneuron-mediated gating of hippocampal activity to inhibit memory consolidation in the Proceedings of the National Academy of Sciences (PNAS) .
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Mov Disord: Neuromelanin changes are highly correlated with the deterioration of Parkinson's disease
Time of Update: 2021-08-14
The study found that in PD, using NM-sensitive imaging, the size and signal intensity of SNpc are reduced, and the diagnostic accuracy is high.
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Mov Disord-After ten years of follow-up, how does the movement, cognition and imaging of Huntington patients change?
Time of Update: 2021-08-14
In addition, combining these data sets can capture a wider range of disease progression fragments (for example, although IMAGE and TRACK have a small number of participants in group 1, PREDICT provides the same larger sample of participants), so it can improve characterization Range .
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Mov Disord: What is the relationship between taking phosphoglycerate kinase 1 activator and the incidence of Parkinson's disease?
Time of Update: 2021-08-14
Their retrospective cohort study included men over the age of 66 who were newly exposed to phosphoglycerate kinase 1 activator or tamsulosin, and compared their incidence of PD using health care administrative data from Ontario, Canada .
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Crit Care: The relationship between cerebrospinal fluid protein biomarkers and prognosis in patients with traumatic and non-traumatic acute brain injury
Time of Update: 2021-08-14
Researchers conducted a comprehensive search of the MEDLINE database and PubMed to determine the concentration of protein biomarkers in the CSF and the neurological outcome of patients with acute brain injury reported [ Traumatic brain injury, subarachnoid hemorrhage, acute ischemic stroke ,Observational study of the relationship between status epilepticus or cardiac arrest].
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Case: 5-year-old child with mental retardation
Time of Update: 2021-08-14
medsci. cn/up/transcode/1628152295377_5541726. m3u8">medsci. cn/up/transcode/1628152295377_5541726. m3u8">medsci. cn/up/transcode/1628152295377_5541726. m3u8">"Metz Live Class: Introduction and Improv
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Stroke: Surface markers of extracellular vesicles can be used as diagnostic indicators for transient ischemic attack
Time of Update: 2021-08-14
Recently, the heart blood vessels published on the prestigious journal Stroke the areas of disease research article, the researchers designed to (1) investigate surface antigen characteristic EV suspected TIA patients; (2) development and validation TIA antigen profile based on a particular surface EV diagnosis Forecast model .
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Circulation: The sooner the better!
Time of Update: 2021-08-14
For patients with atrial fibrillation, the main goal of treatment is to control symptoms and prevent heart failure and prevention of arterial thrombosis embolism, especially stroke .
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JNNP: Longitudinal tissue changes of spinal cord gray matter and white matter after spinal cord injury
Time of Update: 2021-08-14
Changes in the differences between C2/C3 and lumbar enlargement standardized white matter (WM) and gray matter (GM) regions in patients with spinal cord injury (SCI) .
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Neuroradiology: Plain scan CT predicts the time of onset, maybe it will greatly change clinical practice?
Time of Update: 2021-08-14
2. Discuss whether it is feasible to use only the CT attenuation of ischemic brain injury to accurately estimate the onset time of stroke, that is, the CT clock .
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Brain: Affects 80% of stroke patients, decision science teaches you how to improve cognitive recovery after stroke
Time of Update: 2021-08-14
It can be seen that additional interventions in neuroscience decision-making have significantly increased the number of effective cognitive training for severely impaired stroke patients .
It can be seen that additional interventions in neuroscience decision-making have significantly increased the number of effective cognitive training for severely impaired stroke patients .
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Journal of stroke: Stroke caused by atrial fibrillation is treated according to the guidelines of the European Heart Association. How effective is it?
Time of Update: 2021-08-14
consensusIn this way, Mi-Yeon Eun and others of Kyungpook National University in South Korea used real-world data to evaluate the short-term clinical outcome events of oral anticoagulant therapy and non-matching therapy that match (recommended) ESC guidelines in patients with atrial fibrillation-related stroke.
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JNNP: A systematic review and meta-analysis of MRI-guided laser interstitial thermal therapy for drug-resistant epilepsy
Time of Update: 2021-08-14
The work of this article conducts a meta-analysis and systematic review of existing relevant literature on laser interstitial hyperthermia, including postoperative adverse events and important surgical results (stratified by age), and expands the previous literature, etiology and follow-up (FU) time , Including studies of all ages and the etiology of DRE patients .
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Mov Disord: Cognitive behavioral therapy can help reduce the anxiety of Parkinson's patients?
Time of Update: 2021-08-14
It is found that CBT is an effective method to treat anxiety in PD patients, which can reduce situational anxiety, social anxiety and avoidance behavior .
It is found that CBT is an effective method to treat anxiety in PD patients, which can reduce situational anxiety, social anxiety and avoidance behavior .
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Mov Disord: Parkinson: Which proteins in cerebrospinal fluid affect the homeostasis of synuclein
Time of Update: 2021-08-14
They found that: (1) Compared with healthy controls, PD and DLB patients have lower levels of proteins related to neurotransmitter secretion, synaptic plasticity and endolysosomal autophagy .
PD and DLB patients have lower protein content related to neurotransmitter secretion, synaptic plasticity and endolysosomal autophagy .
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Alzheimer's & Dementia: What kind of help do people with dementia and informal caregivers want more: a mixed-method study
Time of Update: 2021-08-14
Ranking activities and discussion results show that patients with dementia prefer home care, help with daily activities, and social activities , while informal caregivers prefer social activities, information about dementia, medical system navigation, and emotional support .
Alzheimer's & Dementia Persons with dementia and informal caregivers prioritizing care: A mixed-methods study (2 021).
