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Alzheimer's & Dementia: Detecting retinal amyloid in clinical trials may help pAD diagnosis
Time of Update: 2021-08-27
The currently approved pAD biomarkers include amyloid ligand positron emission tomography (PET) and cerebrospinal fluid (CSF) amyloid levels ; both methods are used to identify individuals with preclinical and late AD .
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Stroke: Antihypertensive combined with statin therapy can effectively prevent stroke onset
Time of Update: 2021-08-27
Heart blood vesselsIn this way, Jackie Bosch and others of McMaster University in Canada reported a secondary analysis of the pre-defined stroke outcomes of each randomized intervention, based on stroke subtypes, independent predictors, treatment effects of key subgroups, and absolute risk reduction.
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Alzheimers Dementia: What is the national dementia risk in Brazil and what are the implications for China?
Time of Update: 2021-08-27
However, there are only a few reports on the incidence of dementia in developing countries, and only one study included participants under 65 years of age .
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Stroke: After an acute stroke, how does pancreatic islet B cell function affect the prognosis?
Time of Update: 2021-08-27
In non-diabetic patients with acute ischemic stroke, β-cell dysfunction is significantly related to short-term adverse clinical outcomes, and has nothing to do with insulin resistance .
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Alzheimers Dementia: The distribution characteristics of white matter hyperintensity lesions are different, and the effect of predicting cognitive ability is also different
Time of Update: 2021-08-27
Vascular DiabetesIn Alzheimer's disease (AD) patients, WMH appears to be larger than the elderly with cognitive impairment, especially in the periventricular and posterior regions .
In patients with Aβpos-AD, the total and regional WMH volume is larger, especially in S-CC, which is closely related to cognitive decline .
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Stroke: Premature babies, are they more likely to have a stroke in adulthood?
Time of Update: 2021-08-27
Its purpose is: (1) After 43 years of follow-up, determine the estimated value based on population risk for stroke, and its main type and gestational age-related risk estimation at birth;(2) Explore whether these associations change due to gender, fetal growth or birth year;(3) Use co-sibling to assess the potential confounding of common family (genetic or environmental) factors .
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JAMA Sub-Journal: Don’t go for exercise yet—the evidence that physical activity can slow down cognitive decline is here again!
Time of Update: 2021-08-27
In order to evaluate the relationship between physical activity and total tau concentration with baseline and cognitive decline over a period of time, experts from Rush University Medical Center and the Rush Institute of Health and Aging conducted related research, and the results were published in the recent JAMA Network Open In the magazine .
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Stroke: After stroke, do not intensify statin treatment, or greatly increase the mortality rate
Time of Update: 2021-08-27
Dearborn-Tomazos and others of Harvard University used observational studies to describe the statin medication mode of veterans after recent ischemic stroke or TIA in a large national sample .
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Nat Med: A clinical study on the safety and effectiveness of gosuranemab, a monoclonal antibody to Tau protein, in the treatment of progressive supranuclear palsy
Time of Update: 2021-08-27
Not shown Showed no effectHowever, the use of gosuranemab monoclonal antibody reduced the unbound N-terminal tau in the patient's cerebrospinal fluid by 98%, while the use of placebo increased by 11% (P <0.
Nature Medicine Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial.
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JNNP: Incidence and 5 risk factors of white matter hyperintensity progression
Time of Update: 2021-08-27
In order to examine the risk factors for disease progression on an individual patient basis, demographic/unchangeable risk factors (age, gender, and baseline WMH lesion volume) and potentially changeable cardiovascular risk factors (including hypertension, diabetes, Hypercholesterolemia, current smoking status) .
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Alzheimer's & Dementia: Serum metabolome determines the risk of Alzheimer's disease
Time of Update: 2021-08-27
The results of the study showed that changes in apoptosis and the reduction of hippocampal progenitor cell integrity are related to exercise and diet, and can predict the subsequent risk of CD and dementia .
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Stroke: What is the relationship between coronary atherosclerosis and white matter lesions?
Time of Update: 2021-08-27
Johansen and others of Hopkins University previously discovered that among the healthy relatives of early-onset CAD patients, there is an association between the total volume of coronary plaques and the total volume of WMH, which is associated with known vascular risk factors.
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Neurology: Drinking "soy milk" regularly, the brain may become smarter
Time of Update: 2021-08-27
For the NHS, the long-term average dietary intake is calculated through seven repeated food frequency questionnaires (SFFQs), and the SCD was evaluated in 2012 and 2014 .
After major non-dietary factors and specific dietary factors, higher total flavonoid intake is associated with lower SCD probability.
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60% of patients with cerebrovascular disease have hidden onset, how to make early diagnosis, prevention and treatment?
Time of Update: 2021-08-27
consensus Cerebral Small Vascular Disease (CSVD) is a common disease that seriously endangers the health of our people.
Metz Medicine invited the director of the First Affiliated Hospital of Harbin Medical University [Zhang Zhongling] to give online lectures to deeply analyze the clinical features and prevention and treatment of cerebral small blood vessels.
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Heavy: Stroke survivors, exercise more, can greatly reduce all-cause mortality
Time of Update: 2021-08-27
Joundi and others of the University of Calgary in Canada conducted a population-based study using the Canadian Community Health Survey (CCHS) linked to an administrative database to assess: compared with the control group, stroke survivors’ The relationship between PA and long-term mortality risk, while taking into account functional limitations and assessing the difference with age .
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JAMA Sub-Journal: Data of 1 million people from Wang Yongjun’s team suggests that the clinical characteristics, management and efficacy of stroke patients in China
Time of Update: 2021-08-27
In China, in order to improve the compliance of patients with acute ischemic stroke (IS) to evidence-based performance measures and in-hospital results, a multi-faceted quality improvement intervention has been formulated and implemented .
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JNNP: Plasma NfL level and longitudinal change rate of C9orf72 and GRN-related diseases: from customized reference to clinical application
Time of Update: 2021-08-27
NfL levels change in presymptomatic carriers (PS) of FTD/ALS-related mutations, 2-5 years earlier than fully symptomatic disease .
165 neurological health controls evaluated 101 C9orf72 and 86 GRN mutation carriersIn the patient group, the median age of onset (AAO) was 58.
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JAHA: Is there a difference in the risk of stroke after acute and elective cardioversion in patients with atrial fibrillation?
Time of Update: 2021-08-27
Stroke Recently, the heart blood vessels published on the prestigious journal JAHA the areas of disease research article, the researchers included all patients with acute or elective ECV for the first time during the 2011-2018 health care database in the Stockholm area, and missing 30 days after ECV Cox regression analysis was performed for strokes with bloody or unclear etiology, and the CHA2DS2-VASc score, drug treatment, and inclusion year were adjusted .
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Alzheimers Dementia: Screening of 5000 plasma proteins, which ones can predict the risk of dementia?
Time of Update: 2021-08-27
In addition, longitudinal studies have shown that most cognitively normal amyloid-positive people never develop clinical dementia .
For several reasons, circulating proteins are promising targets for biomarker and drug discovery .
Animal studies support the causal role of circulating plasma proteins in neurodegeneration .
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JNNP: Secondary injury and inflammation after intracerebral hemorrhage: A systematic review and meta-analysis of molecular markers in patients’ brain tissue
Time of Update: 2021-08-27
Two or more studies analyzed the same molecule and reported numerical measurements of the association or expression, as well as SE of ICH and control tissues .
