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Alzheimer Dementia: The heavier the cognitive function, the higher the cost of care
Time of Update: 2021-09-29
Burgdorf1 and others of Johns Hopkins University in the United States, based on the community life medical insurance beneficiaries who received HHC from 2011 to 2016, provided for the first time information about the cognitive impairment and nursing intensity of patients during HHC.
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JAMA Neurology: How effective is antiplatelet therapy for stroke after cerebral hemorrhage?
Time of Update: 2021-09-29
After a median follow-up of 537 participants for 2 years, the main results of RESTART ruled out all risks, but there was a very small increase in the risk of recurrence of ICH after antiplatelet therapy (adjusted hazard ratio [HR] , 0.
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JNNP: Higher blood high-density lipoprotein and apolipoprotein A1 levels are associated with a reduced risk of amyotrophic lateral sclerosis
Time of Update: 2021-09-29
High levels of low-density lipoprotein cholesterol (LDL) apolipoprotein A1 are associated with an increased risk of subsequent ALS.
A combination model was also constructed, including demographic variables, cardiovascular and cerebrovascular diseases, smoking and statin use, as well as all cases of ALS events and excess MET and blood biomarkers in patients diagnosed with ALS more than 5 years from registration .
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Neurology: What are the predictors of epilepsy after ischemic stroke?
Time of Update: 2021-09-29
The risk factors for post-stroke epilepsy are acute symptomatic attacks, more severe strokes, infarctions involving the cerebral cortex, and strokes caused by arteriosclerosis .
No association was found between reperfusion therapy and the risk of acute symptomatic seizures or post-stroke epilepsy .
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Alzheimer's & Dementia: How to prevent Alzheimer's disease by 2025: A brief analysis of the goal-risk-AD-prevention (TRAP) strategy
Time of Update: 2021-09-29
Women’s lifetime risk of developing AD is twice that of men, accounting for more than 60% of patients with the disease.
Preventive diagnosis If the onset of AD is delayed by 1 year in 2020, it will lead to a reduction of approximately 9 million cases in 2050.
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Stroke: The effect of previous antiplatelet therapy on the outcome of acute stroke patients after endovascular treatment
Time of Update: 2021-09-29
The effect of previous use of antiplatelet therapy (APT) on the outcome of acute ischemic stroke patients receiving endovascular therapy is not yet clear .
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JAMA Neuro: Which is more effective?
Time of Update: 2021-09-29
Immune diagnosisSubsequently, for verification, 122 participants (51 with normal cognition, 51 with MCI, and 20 with AD dementia) were included from the AD neuroimaging initiative, using IP-MS-WashU, IP-MS-Shim, IP- MS-UGOT, IA-Elc, IA-N4PE and IA-Quan detection methods were used for Aβ-PET and plasma Aβ assessment .
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Mov Disord: Using longitudinal data can more effectively predict the prognosis of Parkinson's patients
Time of Update: 2021-09-29
of Duke University in the United States established a prognostic model and used a variety of easily available longitudinal measurement methods to predict the time-based clinical trial of early PD from Hehn and Yahr (H&Y) Phase 1 or Phase 2 to Phase 3.
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Alzheimer's & Dementia: Are TNF-α inhibitors more effective than methotrexate in preventing AD?
Time of Update: 2021-09-29
Researchers used insurance claim data from a database of patients eligible for commercial insurance and medical insurance to estimate the risk of dementia and AD in rheumatoid arthritis (RA) patients who started using TNF inhibitors and those who started using methotrexate .
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Mov Disord: What is the basis of the gray matter structure of progressive supranuclear palsy and speech disorder?
Time of Update: 2021-09-29
Clark and others of the Mayo Clinic in the United States explored the relationship between gray matter volume and white matter duct integrity, oral and pharynx dysphagia, and airway invasion .
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Mov Disord: Multi-target transcranial electrical stimulation, the treatment of frozen gait, how effective
Time of Update: 2021-09-29
Based on this evidence and the presumptive role of the cognitive-motor link in FOG, they conducted a randomized controlled trial to test the hypothesis that multi-course TDCS intervention for left dlPFC and M1 would reduce FOG and improve related results .
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TCMIVD: Traditional Medicine Brings New Expectations-Traditional Chinese Medicine Intervenes Vascular Dementia
Time of Update: 2021-09-29
Invigorating the kidney and essence, invigorating the spleen and qi, resolving phlegm and resuscitation, promoting blood circulation and blood stasis, calming the liver and yang, calming and nourishing the mind, are the methods of traditional Chinese medicine to treat VD .
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JNNP: Clinical phenotype of type 2CC peroneal muscular atrophy caused by NEFH mutation
Time of Update: 2021-09-29
The new findings of this study and the previously published pedigree of the 2CC peroneal muscular atrophy familyThis became apparent in 70% of patients (21/30) early in the course of the disease, and the average time from symptom onset to proximal involvement was 4.
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Mov Disord: polygenic score, which can predict the incidence of Parkinson's
Time of Update: 2021-09-29
Current methods lean toward the "common disease, common variant" hypothesis, in which low-risk alleles account for most of the genetic board widely known as the polygenic risk score (PRS) .
28761Polygenic Risk Scores in a Prospective Parkinson's Disease Cohort.
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Alzheimer's & Dementia: An ultra-sensitive immunoassay to predict Alzheimer's disease
Time of Update: 2021-09-29
It can label Aβ plaques in non-fixed AD brain slices and can effectively neutralize AD brain-derived oAβ Synaptic toxicityTherefore, researchers have created a sensitive, high-throughput, and cost-effective method to quantify synaptic toxicity oAβ in human plasma, which is promising for high-throughput analysis of elderly and AD subjects to evaluate this The dynamics of key pathogenic species and their response to treatment .
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Nat Aging: Reprogramming factors help glial cells "rejuvenate"
Time of Update: 2021-09-29
Inhibition in aging induces an aging-like phenotypeIncreasing the expression of c-Myc in elderly OPCs in vivo can restore their proliferation and differentiation ability, thereby enhancing the regeneration ability in the environment of the elderly central nervous system .
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Alzheimer Dementia: How long is the best time to sleep every day to prevent dementia?
Time of Update: 2021-09-29
They used Cox regression analysis to explore the relationship between sleep time, insomnia, and daytime naps and the occurrence of all-cause dementia among 397,777 middle-aged people, and their interaction with the genetic risk of APOE .
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Neurology: Natalizumab (natalizumab), the treatment of drug-resistant focal epilepsy, how effective and safe
Time of Update: 2021-09-29
French of New York University and others hypothesized that by reducing the BBB dysfunction caused by white blood cell-vascular interaction, natalizumab increases the threshold of seizures, thereby reducing the recurrence of epilepsy .
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JAMA Sub-Journal: Attention, too much sleep and too little sleep are all related to depression and Alzheimer's!
Time of Update: 2021-09-29
287Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging.
287Association of Short and Long Sleep Duration With Amyloid-β Burden and Cognition in Aging.
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Neurology: What is the clinical specificity of cerebral venous thrombosis?
Time of Update: 2021-09-29
CVT in adolescents is rare and complex, with special epidemiological characteristics , including differences in clinical manifestations and related conditions between different sexes, as well as more serious results than adults .
