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Zhiqi Xiong's team reveals the pathological mechanism of PRRT2 gene mutations leading to paroxysmal movement disorders
Time of Update: 2021-09-30
Life science On September 21, 2021, the Xiong Zhiqi team of the Chinese Academy of Sciences Brain Science and Intelligent Technology Excellence Innovation Center and the Shanghai Brain Science and Brain-like Research Center published a long article in the journal Cell Reports under the Cell Press titled "Cerebellum The research paper on "Cerebellar spreading depolarization mediates paroxysmal movement disorder" reveals the pathological mechanism of PRRT2 gene mutations leading to paroxysmal movement disorder .
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Nature Sub-Journal: New Technology!
Time of Update: 2021-09-30
On September 6, 2021, Steven Finkbeiner's research team at the Gladstone Institute in San Francisco modified the gene-encoded calcium ion indicator to develop a fluorescent probe GEDI that marks dead cells so that it can be located in the cytosol.
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What to do if you smell fried chicken while losing weight?
Time of Update: 2021-09-30
Image source: 123RF In the experiment, the researchers let the subjects smell a mixed odor of food and non-food, such as the odor mixture of "pizza-pine" or "cinnamon bun-cedar".
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Research reveals new mechanism of paroxysmal dyskinesia
Time of Update: 2021-09-30
Studying model mice based on paroxysmal kinesigenic dyskinesia (PKD), using electrophysiological, calcium imaging, and behavioral analysis techniques to prove that mutations in the PKD pathogenic gene PRRT2 can cause depolarization of the cerebellar cortex Spreading depolarization is susceptible.
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Clinical manifestations, outcome and management of delirium in critically ill patients
Time of Update: 2021-09-30
Among more than 25,000 patients in nearly 100 hospitals, the A2F clustering strategy showed dose-effect dependence characteristics (such as higher compliance, better results), which can improve survival rate, shorten hospital stay, shorten the duration of coma and delirium, Save treatment costs and reduce the number of ICU reentry .
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Precise diagnosis and treatment first-the application of biomarkers in precise diagnosis and treatment of diseases NCN2021
Time of Update: 2021-09-30
Figure 1 Types of biomarkers The development and application of biomarkers has promoted the transformation of clinical diagnosis and treatment models, and provided the possibility for the development of precision therapy (Figure 2) .
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Researchers have discovered early signs of Alzheimer’s disease in the brain｜《Science · Translational Medicine》
Time of Update: 2021-09-30
According to a new analysis by Heidi Jacobs and colleagues, the integrity of the locus coeruleus (LC) area in the brain stem is related to some of the main features of early Alzheimer’s disease, including toxic proteins.
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It is expected to slow down or stop the progress of DMD!
Time of Update: 2021-09-30
Recent popular reports from Yimaike ★NoticeShanghai Minhang Biopharmaceutical Industry Development Conference and 2021 Life and Health Industry Summit Forum is about to open in Shanghai ★September·ShanghaiOncolytic Virus Drug Development Forum is about to open Click on the picture and sign up for the conference September 25, 2021 EMedClub News/--Recently, the life science company Solid Biosciences released the latest phase I/II clinical trial results of the gene therapy SGT-001 for Duchenne muscular dystrophy (DMD).
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Cerebral Venous Thrombosis: Focus on Five Hot Issues NCN 2021
Time of Update: 2021-09-30
*It is only for medical professionals to read and explain, not to be missed! Cerebral venous thrombosis (CVT) refers to the formation of intracranial vein or venous sinus thrombosis caused by various
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Professor Wang Yongjun: Looking back and looking forward, a new journey of antiplatelet therapy for ischemic stroke
Time of Update: 2021-09-30
Figure 3: Comparison of CAST and IST research Professor Wang Yongjun introduced that based on these two famous clinical studies, aspirin has been written into the guidelines of various countries since 1998, opening a new era of aspirin treatment of ischemic stroke .
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Deletion of EMBO J︱ neuron Miro1 protein disrupts mitochondrial autophagy and over-activates the integrated stress response
Time of Update: 2021-09-30
, EMBO J 2021; 40: e100715) Figure 5 Work summary diagram: Miro1 deletion leads to long-term destruction of mitochondrial homeostasis and mitochondrial fusion, mitochondrial remodeling and integrated stress response ( ISR) continues to be activated .
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Three in and three out?
Time of Update: 2021-09-30
First, the patient’s initial cerebrospinal fluid showed hemorrhage, but other inflammatory markers (cerebrospinal fluid protein, IgG synthesis rate/index, and OCB) were in the normal range; the segmental stenosis seen on the initial cerebral angiography was 2 months After alleviation, RCVS is more supported .
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Professor Chen Biao: It is not too late to understand the staging and intervention of Alzheimer's disease!
Time of Update: 2021-09-30
Early, middle and late AD patients show a series of cognitive impairments, the most prominent manifestation is memory problems, and secondly, patients also show mental symptoms and personality changes, which will affect the patients' daily life and work ability .
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Hot research The latest research progress of Alzheimer's disease
Time of Update: 2021-09-30
51237 About Alzheimer's disease published by Wiley Disease research journal MoreWiley promotes world progress and development with scientific research and education25910 Original title: Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome from the journal: Annals of NeurologyJanuary 2021 Original link: https://onlinelibrary.
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Express significantly relieves the symptoms of advanced DMD patients, and the Phase 2 clinical results of cell therapy are positive
Time of Update: 2021-09-30
▎Editor of WuXi AppTec's content team On September 24, 2021, Capricor Therapeutics announced the final results of a phase 2 clinical trial of cell therapy CAP-1002 for the treatment of patients with advanced Duchenne muscular dystrophy (DMD) .
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Brain abscess, brain cyst with hemorrhage, spinal cord subacute combined degeneration 3 minutes, 33 phase
Time of Update: 2021-09-30
Diagnosis: Brain abscess (pathological) Case discussion: The image shows a subcutaneous cystic space on the right frontal area, which is "mushroom-like", the skull is eroded and destroyed, and invades the dura mater, ring-enhanced, and partitioned inside .
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For the treatment of rare diseases!
Time of Update: 2021-09-30
Recent popular reports from Yimaike ★NoticeShanghai Minhang Biopharmaceutical Industry Development Conference and 2021 Life and Health Industry Summit Forum is about to open in Shanghai ★Bluebird sub
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Liu Qiang/Xu Huaxi team collaborated to discover a new mechanism for RNA-binding protein to regulate brain aging and Alzheimer's disease
Time of Update: 2021-09-30
On September 23, 2021, Professor Liu Qiang from University of Science and Technology of China and Professor Xu Huaxi from Xiamen University jointly published a research paper on Molecular Neurodegeneration Nuclear speckle specific hnRNP D-Like prevents age- and AD-related cognitive decline by modulating RNA splicing, the article reveals The RNA-binding protein hnRNP D-Like participates in a new mechanism that regulates brain aging and Alzheimer's disease by regulating the RNA alternative splicing process of neurons .
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Randomized controlled trial: Can Omega-3 supplementation in patients with Alzheimer's disease maintain memory function?
Time of Update: 2021-09-30
Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial—The OmegAD Study.
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Courier allows specific children with DMD to walk for 5 more years!
Time of Update: 2021-09-30
Data from 241 patients indicate that compared with standard treatment (SoC) alone, Translarna can delay the inability to get out of bed in boys with nonsense mutant Duchenne muscular dystrophy (nmDMD) by more than 5 years, and the decline in lung function is also delayed on average 1.
