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Professor Sun Yongan: Starting from the pathogenesis, solving the key problems in AD diagnosis and treatment
Time of Update: 2021-10-10
Professor Sun Yongan said that in the neurology department where he works, the number of dementia patients caused by AD has surpassed that of cerebrovascular disease, and other departments often come into contact with AD patients in their diagnosis and treatment work .
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BMJ: So many depression screening scales, are you using it right?
Time of Update: 2021-10-10
diagnosisIn order to update the previous meta-analysis of individual participant data, determine the most commonly used depression screening tool in general practice-Patient Health Questionnaire-9 (PHQ-9) in the detection of major depression in the overall and research or participant subgroups Accuracy, experts from the University of Montreal in Canada conducted a comprehensive and systematic review, and the results were published in the BMJ magazine .
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Interview with Professor Zhao Yuwu: Management of Blood Pressure Variability in Hospitalized Patients with Ischemic Stroke
Time of Update: 2021-10-10
Yimaitong: "Shanghai Expert Recommendations on the Management of Blood Pressure Variability in Inpatients with Ischemic Stroke" for reducing BPV in patients with hypertension?
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Nature: Saturated lipids induce astrocytes to actively kill neurons
Time of Update: 2021-10-10
The saturated lipids contained in APOE and APOJ lipid particles are the "primordial culprits" that mediate the toxicity induced by astrocytes, not proteins .
Neurotoxic reactive astrocytes induce cell death via saturated lipids Nature (2 021).
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Wish you remember me-Heliyon selection of World Alzheimer's Day
Time of Update: 2021-10-10
Use multi-convolutional neural network for hippocampus segmentation for epilepsy and Alzheimer's disease research The Diedre Carmo team of the University of Campinas in Brazil published the latest research .
Research results show that inhalation of V2O5 can induce cell death similar to Alzheimer's disease, and there are obvious cytoskeletal changes .
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ELife︱The sorting protein SNX27 regulates the transport of AMPA receptors through the synaptoadhesin LRFN2
Time of Update: 2021-10-10
Written by Wang Peixiang, edited by Wang Peixiang, Wang Sizhen The endosome network plays a key role in regulating cell surface functions, and this role is mainly achieved through the sorting mechanism of endocytic proteins, that is, the endocytosed integrin can be transported Degraded by the lysosome, it can also be transported to the plasma membrane for reuse through the circulation route [1] .
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Alzheimer's & Dementia: Pulmonary dysfunction actually affects cognitive ability
Time of Update: 2021-10-10
Researchers have found that low PF is related to the rapid decline of overall cognition and specific domain functions , including explicit memory, semantic memory, working memory, visuospatial ability, and perception speed .
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Early anticoagulation of acute ischemic stroke, before operation, during operation, and after operation, all in one article!
Time of Update: 2021-10-10
In 2015, a systematic review reviewed 24 RCT studies on early anticoagulation treatment of AlS from 2008 to 2014, (21 of which used UFH), 23748 patients, and the results showed that anticoagulation therapy can reduce the recurrence rate of AlS , Pulmonary embolism and deep vein thrombosis rates, but are offset by the increased risk of intracranial hemorrhage [3] .
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PLOS ONE: Is it useful to stay up late to make up for sleep?
Time of Update: 2021-10-10
The time taken by the patient to perform the task in accuracy (top) and reaction time (bottom)The results showed that during the sleep restriction period, all measurement indicators showed a consistent decline .
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Express treatment of Alzheimer's disease, Eisai/Bojian's second amyloid antibody therapy starts rolling application
Time of Update: 2021-10-10
▎Editor of WuXi AppTec's content team On September 27, Eisai and Biogen jointly announced that they have submitted a rolling submission for the treatment of early-stage Alzheimer's disease (AD) antibodies to the US FDA through the accelerated approval channel Biological product license application (BLA) for the therapy lecanemab (BAN2401) .
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JNNP: The gray matter changes of the thalamus can reflect the visual hallucinations of Parkinson's patients
Time of Update: 2021-10-09
The important significance of this study lies in the discovery: PD hallucinations show white matter loss, especially in the posterior connection and the thalamic nucleus, and the thickness of the cortex is relatively preserved over time .
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Stroke: Amyloid angiopathy, iron deposition on the surface of the cerebellum may be a new indicator
Time of Update: 2021-10-09
5 out of 50 Dutch type hereditary CAA patients (10%[95%CI, 2-18]) had superficial cerebellar spider web disease, 4/45 (9%[95%CI, 1-17]) In sporadic CAA patients, 0 (0%[95%CI, 0-8]) of 43 patients with intracerebral hemorrhage related to deep perforating arterial lesions were present .
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Stroke: Tiantan Hospital: The influence of antiplatelet therapy on the prevention of ischemic events after intracranial aneurysm stent surgery
Time of Update: 2021-10-09
A randomized controlled trial showed that compared with standard antiplatelet therapy, changing antiplatelet therapy under the guidance of platelet function monitoring can reduce the frequency of thromboembolic events without increasing the amount of bleeding.
Antiplatelet therapy under the guidance of platelet function monitoring reduces thromboembolic events in patients with unruptured intracranial aneurysms after stent placement.
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Stroke: How to manage stroke during pregnancy?
Time of Update: 2021-10-09
Although this retrospective multicenter study concluded that pregnant women and postpartum women had similarly good short-term results after any acute reperfusion therapy (thrombolysis, intravascular or catheter-based), this study did not study mechanical thrombectomy MT itself,In addition, this evaluation was carried out before the publication of clinical trial data in 2015, which verified the effectiveness of MT in the general stroke population .
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Alzheimer Dementia: What are the characteristics of amyloid distribution in different areas of the brain?
Time of Update: 2021-10-09
They evaluated 24 amyloid beta (Aβ)+ patients with atypical, early-onset absence or non-absence AD and 62 Aβ- and 132 Aβ+ Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants in 18 F-flortaucipir PET imaging changes between regions and individuals .
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Stroke: Patients with embolic stroke of undetermined origin, frequency and pattern of cerebral infarction
Time of Update: 2021-10-09
No one has described in detail the number and pattern of recent cerebral infarctions detected by magnetic resonance imaging (MRI) in ESUS patients before stroke .
Among eligible ESUS people who had no history of stroke or transient ischemic attack before, 68% (510/755) had multiple cerebral infarctions .
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Alzheimer Dementia: Tianjin Medical University: Poor lung function, or cognitive decline
Time of Update: 2021-10-09
Some epidemiological studies have shown that there is an association between PF indicators (including FEV1, FVC, and PEF) and the overall cognitive decline of the elderly .
12479 Pulmonary function is associated with cognitive decline and structural brain differences.
12479 Pulmonary function is associated with cognitive decline and structural brain differences.
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Alzheimer Dementia: In the early stage of dementia, multiple markers can be combined to predict the progression of dementia
Time of Update: 2021-10-09
In this way, Line Kühnel1 of the University of Copenhagen and others have developed and verified a continuous prediction model based on biomarkers, which allows to reduce the test sample size while defining the personal cognitive prognosis at any time in the future .
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JNNP: High-density lipoprotein may reduce the risk of frostbite
Time of Update: 2021-10-09
Higher levels of low-density lipoprotein cholesterol (LDL) and apolipoprotein B:A1 are associated with an increased risk of subsequent ALS, with temporal changes in lipid biomarkers observed in the decade before diagnosis .
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JNNP: Longitudinal changes in thalamic white matter and gray matter related to visual hallucinations in patients with Parkinson's disease
Time of Update: 2021-10-09
Visual hallucinations (VH) are common in Parkinson’s disease (PD) and can cause severe suffering to affected individuals and their families, leading to worse results: patients with Parkinson’s disease
