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Stroke: Cerebral hemorrhage caused by coagulopathy, andexanet alfa treatment did not change the clinical prognosis
Time of Update: 2021-10-20
We explored whether the use of andexanet alfa treatment is related to the reduction of hematoma enlargement (HE) rate and the improvement of clinical outcomes in patients with traumatic fXi-ICH compared with conventional care including PCC .
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JNNP: The relationship between early and late direct oral anticoagulants after acute ischemic stroke in patients with atrial fibrillation
Time of Update: 2021-10-20
A recent analysis of individual patient data from seven prospective observational studies found that DOAC is better than VKA in the early stages after AIS .
In the summary analysis of individual patient data in this prospective observational study, this article compares the 30-day recurrence of AIS, ICH, and mortality (≤ 5.
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JAD: Not happy at a young age?
Time of Update: 2021-10-20
The results showed that in a separate model, the increase in depressive symptoms at each life stage was associated with cognitive outcomes: the risk of cognitive impairment in early adulthood increased by 59% (20-49 years old, OR=1.
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Parkinson's drug MLR-1019 has begun mass production for phase IIa clinical trials
Time of Update: 2021-10-20
Adhera is actively conducting a Phase IIa study, which aims to be a multi-center, double-blind, randomized, placebo-controlled clinical trial in Eastern Europe to evaluate the effectiveness and safety of MLR-1019 in the treatment of Parkinson's.
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Neurology: Neurofascin-155 immunoglobulin subtypes, clinicopathological associations and neurological outcomes
Time of Update: 2021-10-20
Finally, the phenotypic differences and results of NF155-IgG4-positive cases and myelin-associated glycoprotein (MAG)-IgM and Contactin-1 IgG-related demyelinating neuropathy were compared .
Compared with MAG-IgM neuropathy, sensory ataxia, neuropathic pain, cerebellar dysfunction, and root/plexus MRI abnormalities are significantly more common in NF155-IgG4-positive patients .
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stroke: Tiantan Hospital: Malnourished people have worse outcomes for stroke
Time of Update: 2021-10-20
Recent studies have used objective scores to assess the risk of malnutrition in stroke patients, and reported that the risk of malnutrition at admission is associated with poor short-term outcomes .
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Stroke: What are the symptoms of stroke patients before hospitalization?
Time of Update: 2021-10-20
diagnosisThe relationship between prehospital fluctuations and changes in hospital NIHSS (admission to 72 hours or discharge) and 90-day results were studied .
5% observed pre-hospital fluctuations, including improvement, deterioration, or both .
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Neurology: Young people with concussion, why does exercise aggravate symptoms
Time of Update: 2021-10-20
However, there are few experimental studies on the mechanism link between cerebral vascular activity, cerebrovascular response to aerobic exercise and exacerbation of exercise-related symptoms after a concussion .
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Annals of Neurology: Using aspirin before stroke can improve the prognosis of cerebral infarction
Time of Update: 2021-10-20
In this way, Wi-Sun Ryu and others of Dongguk University in South Korea conducted a study on 5700 patients with first acute ischemic stroke, and hypothesized that the use of aspirin before stroke and the reduction of cerebral thrombosis, smaller infarction, and fewer early nerves System deterioration is related to the functional outcome of 3 months .
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[Live Preview] Diagnosis and Treatment of Youth Stroke
Time of Update: 2021-10-20
Common causes of stroke in youthStroke2.
Clinical features and diagnosis of stroke in young peoplediagnosis3.
Treatment of youth stroke Live time: 19:00, October 15, 2021Live time: Guest introductionGuest Introduction Guest IntroductionWang Xun, female, doctor, postdoctoral, chief physician .
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Lancet Neurology: Stroke may become the "top killer" of world health
Time of Update: 2021-10-20
This study surveyed 204 countries and regions from 1990 to 2019, and analyzed the incidence, morbidity, mortality, disability-adjusted life years (DALY) and DALY associated with 19 risk factors.
Globally, in the past 30 years, the total number of stroke-related DALYs due to risk factors has increased significantly.
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JNNP: 7TPC-MRA to evaluate the blood flow velocity of the lenticular artery in CADASIL patients
Time of Update: 2021-10-20
Ultra-high MRI provides a non-invasive method for us to study the speed of the lenticular artery (LSA) in CADASIL patients .
Ultra-high MRI provides a non-invasive method for us to study the speed of the lenticular artery (LSA) in CADASIL patients .
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Nat Aging: APOE ε4 can positively affect the visual working memory of the elderly
Time of Update: 2021-10-20
ε4 carriers have a variety of different survival advantages, including improved fertility, resistance to infection, reduced perinatal and infant mortality, and some minor cognitive advantagesRecently, in people born within the same week in 1946 (evaluation age 69-71 years), researchers evaluated the effects of APOE ε4 and β-amyloid pathology (quantified by 18F-Florbetapir-PET) on visual working memory (objects).
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Circ-Heart Fail: Heart failure in patients with and without severe mental illness and its relationship with long-term outcomes
Time of Update: 2021-10-20
Clinical Heart Failure Among Patients With and Without Severe Mental Illness and the Association With Long-Term Outcomes .
https:// href="https://" target="_blank" rel="noopener">Clinical Heart Failure Among Patients With and Without Severe Mental Illness and the Association With Long-Term Outcomes in this message
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Neurology: 1-year follow-up: the correlation between pre-stroke blood glucose control and vascular events
Time of Update: 2021-10-20
Recently, a study published in Neurology investigated the relationship between the risk of glycosylated hemoglobin (HbA1c) and subsequent complex vascular events (including stroke, myocardial infarction (MI), and vascular death) in patients with acute ischemic stroke and DM on admission .
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Stroke: After a stroke, sleep apnea can be improved by training
Time of Update: 2021-10-20
In addition, they also studied whether compared with iPSG, the use of HSAT to screen sleep apnea increased the proportion of patients prescribed CPAP, reduced daytime sleepiness, improved sleep-related quality of life and functional results after 6 months, and Enhance the patient's experience of sleep testing .
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BTK inhibitor tolebrutinib in the treatment of multiple sclerosis (MS) shows "promising" results
Time of Update: 2021-10-20
Estimated dose-response curve after applying two-step multiple comparison procedure and modelingThe results of the Phase IIb Long-Term Extended Study (LTS) showed that after 48 weeks of treatment, the BTK inhibitor tolebrutinib reduced the activity of multiple sclerosis (MS) disease .
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Nat Commun: Ipilimumab and Nivolumumab in the treatment of meningeal carcinoma: a phase II study
Time of Update: 2021-10-20
The side effects of these traditional treatments are still a major problem infectionRecently, researchers proposed a single-arm phase II study in which 18 patients with LMD received a combination of ipilimumab and nivolumumab until the disease progressed or unacceptable toxicity (NCT02939300) .
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Clin Nutr: Zheng Liangrong's team from the First Affiliated Hospital of Zhejiang University found that high dimensional C levels can reduce the risk of cardiogenic stroke and Alzheimer's disease!
Time of Update: 2021-10-20
Heart blood vesselsZheng Liangrong, director of the Department of Cardiology, Zhejiang University First Affiliated Hospital, led his team to conduct a Mendelian randomized (MR) study to explore the relationship between vitamin C and 9 cardiovascular diseases (coronary artery disease [CAD], myocardial infarction [MI], atrial fibrillation) [AF], heart failure [HF], stroke , ischemic stroke [IS] and IS subtypes) and the causality of Alzheimer’s disease risk .
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JNNP: New mutation in SOD1 is a cause of ALS
Time of Update: 2021-10-20
After the SOD1 mutation was found in four cases of sALS, after genetic counseling, at least three generations of medical genealogy studies were conducted on these families .
