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Check it out!
Time of Update: 2022-03-06
On February 3, 2022, the research team of Nicolas Renier of the Brain Institute of the Sorbonne University in Paris revealed the key neuron group that regulates the adaptive behavior (nesting behavior) of pregnant mice: the CART-positive neuron group in the EA area, which inhibits this type of neuron group After inhibiting nesting behavior, activate the neuron to promote nesting behavior .
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Important progress in understanding Alzheimer's disease!
Time of Update: 2022-03-06
News from the research institute states that this study provides the first high-resolution structure of Aβ42 protein fibrils derived from human brain tissue .
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Wang Liping's team assesses the impact of development and evolution on sequential learning and memory
Time of Update: 2022-03-06
Through behavioral analysis and modeling, the study found that when adults, children and macaques completed the same spatial sequence task, there were not only differences in the accuracy of information encoding, but also differences in the processing methods of relational structures .
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The 2022 Lysosomal Disease Annual Meeting Gene Therapy Big Inventory Yi Mai Meng broke the news
Time of Update: 2022-03-06
On February 9, 2022, Astellas announced positive interim data from a Phase 1/2 clinical trial of its AAV gene replacement therapy AT845, which provides a functional alpha-glucosidase (GAA) gene for the treatment of late-onset Pompe disease (LOPD) .
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Eliminate cancer cells in 30 minutes! Where is the domestic anticancer boron drug sacred?
Time of Update: 2022-03-06
com/amphtml/20220125A0369G00[3] China's first anti-cancer boron drug has completed the pilot test and is expected to be used in clinical practice in 2023 https://baijiahao.
com/s?id=1718634397449191617&wfr=spider&for=pc[5] China's first anti-cancer boron drug completes the pilot test, the fastest 30 Many specific cancers can be cured in minutes!
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An important role of VIP neurons in the regulation of odor representation and olfactory function in the olfactory bulb
Time of Update: 2022-03-06
This study elucidates the basic properties of vasoactive intestinal peptide-expressing (VIP) neurons, a class of interneurons widely distributed in the outer reticular and glomerular layers of the olfactory bulb, and their relationship with olfactory bulb output neurons - Synaptic connections between mitral and tufted cells (M/Ts) and their important role in olfactory-related behaviors .
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Nat Metab Wang Kailiang/Bian Zhaoxiang collaborated to discover the regulatory mechanism of satiety and a new target for the treatment of obesity
Time of Update: 2022-03-06
Editor | xi Obesity is an emerging global health threat that affects people of all ages . Being overweight, especially obesity, puts people at higher risk for life-threatening diseases such as hea
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One article to clarify headache, neck pain, cervical spondylosis, no longer foolishly unclear
Time of Update: 2022-03-06
Author: Tinyel This article is published by the author with the authorization of Yimaitong, please do not reprint without authorization . Let's look at a case first . A young female patient compla
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Journal of Cell Biology Collector's Edition Review Sheng Zuhang's team summarizes the important role of neuronal endosome-lysosomal transport and function in maintaining axon homeostasis
Time of Update: 2022-03-06
This article provides an in-depth discussion of the regulatory mechanisms of endosome-lysosomal axonal transport and distribution in normal neurons, as well as the important role of lysosomal maturation and function in maintaining neuronal survival, and further elucidates the occurrence of both.
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Neuron Tan Chao et al. A small molecule protein developed based on the zinc finger domain of RIM protein and calcium channel subunit β4 to rebuild the core function of the active area in the synapse
Time of Update: 2022-03-06
The main function of the active zone is to achieve vesicle docking with the presynaptic membrane (vesicle docking), increase the fusion ability of vesicles (vesicle priming), and couple calcium ions to guide vesicle fusion to complete neurotransmitter release .
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Damaged brain 'firewall' after stroke?
Time of Update: 2022-03-06
Based on these phenomena, the joint research team of Professor Li Weiqiang and Xiang Peng from the Stem Cell and Tissue Engineering Research Center of Sun Yat-Sen University published a study in "Nature-Communications" and found that after transplantation of stem cell-derived pericytes into a mouse model of stroke, the Repairs broken blood-brain barrier and reduces neuronal death .
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Alzheimers Dementia: Lipid species may influence the relationship between APOE and dementia
Time of Update: 2022-03-05
Plasma lipid species mediate the therapeutic effect of APOE genotype in Alzheimer's disease Original source: [Wang T, Huynh K, Giles C, et al.
APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies.
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JNNP: acute ischemic stroke associated with SARS-CoV-2 infection
Time of Update: 2022-03-05
Infection Stroke Statistics The primary objective of this study was to identify factors associated with poor prognosis and mortality in these patients .
vascular diabetes hypertensionThe mRS scores are: (A) total sample size based on age; (B) severity of coronavirus disease; and (C) hypercoagulable statusChoose to use system markers to classify severity of COVID-19 inflammation .
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Neurology: Among acute stroke (AIS) patients receiving endovascular therapy (EVT), patients with active cancer had worse functional outcomes at 90 days!
Time of Update: 2022-03-05
Prognostic indicators were 90-day modified Rankin Scale (mRS) score, mortality, reperfusion success rate (ETICI score ≥2b), symptomatic intracranial hemorrhage (SICH), and recurrent stroke .
Prognostic indicators were 90-day modified Rankin Scale (mRS) score, mortality, reperfusion success rate (ETICI score ≥2b), symptomatic intracranial hemorrhage (SICH), and recurrent stroke .
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Stroke: Frail patients with atrial fibrillation, better prognosis with anticoagulation
Time of Update: 2022-03-05
All four individual direct OACs were associated with a reduced risk of net adverse clinical events, ischemic stroke, major bleeding, and cardiovascular death compared with warfarin .
All four individual direct OACs were associated with a reduced risk of net adverse clinical events, ischemic stroke, major bleeding, and cardiovascular death .
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Researcher Tang Shiming was interviewed by CGTN to analyze how athletes remember the sequence of difficult movements?
Time of Update: 2022-03-05
The paper , published in the journal Science on February 11 , reports the encoding mechanism of sequence memory by group neurons in the prefrontal cortex of macaque monkeys, which may provide new ideas for the development of artificial intelligence .
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Neurology: AFFINITY trial: The degree of neurological deficit after stroke increases the risk of depression, and social relationships and cultural background can help reduce the risk
Time of Update: 2022-03-05
Here, we sought to identify sociodemographic and clinical factors associated with early, late, and persistent clinically significant symptoms of depression in the first year of stroke .
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EHJ: Real hammer!
Time of Update: 2022-03-05
In a country like China with more than 300 million smokers, it is particularly important to strengthen tobacco control and reduce cardiovascular and cerebrovascular diseases caused by smoking and second-hand smoke .
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PLOS MED: Circadian differences in stroke onset - serious consequences with greater likelihood of nocturnal onset
Time of Update: 2022-03-05
At 3 months, the rate of good functional outcomes had a monotonic gradient, decreasing from a peak at 06:00 to 10:00 to a trough between 22:00 and 02:00Compared with day-onset strokes, nocturnal-onset strokes had higher neurological severity, more frequent END, and worse 3-month functional outcomes .
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Stroke: Multimodal neuroimaging and behavioral data to predict speech rehabilitation in stroke
Time of Update: 2022-03-05
The significance of this study lies in the discovery that while behavioral, multimodal neuroimaging data, and demographic information are complementary in predicting recovery responses in chronic aphasia after stroke, resting brain functional connectivity after stroke is a predictor of A particularly important factor in treatment responsiveness , either alone or in combination with other patient-related factors .
