-
Movement disorders: New approach: Neuromelanin approach tracks melanin deposition in Parkinson's disease
Time of Update: 2022-04-22
, from Nottingham Medical College, UK, proposed a large prospective multicenter case-control NM-MRI study based on standardized template analysis to: (1) investigate NM in early PD in a multiprotocol setting The diagnostic accuracy of sensitive MRI; (2) to determine and compare annualized serial NM-MRI changes in patients and controls .
-
Lancet sub-issue: 500,000 Chinese studies suggest that lacunar cerebral infarction is not harmless, and the 5-year recurrence rate is nearly 40%!
Time of Update: 2022-04-22
LancetIn a prospective study of 489,597 Chinese adults with no history of stroke or ischemic heart disease at baseline, the researchers compared the 5-year risk of recurrent stroke and all-cause death for silent lacunar infarction with symptomatic lacunar infarction .
-
JAMA N: Which drug should be used for epilepsy after stroke?
Time of Update: 2022-04-22
The association of poststroke epilepsy (PSE) with mortality varied across studies, but the hazard ratio (HR) for death appeared to increase at the population level .
-
Science: Major progress!
Time of Update: 2022-04-22
This LTD effect induced by captopril was blocked by opioid receptor antagonists, suggesting that inhibition of ACE activity reduces D1-MSN excitatory input through endogenous opioid receptors .
-
JAHA: Cardiovascular risk in patients with schizophrenia, schizoaffective disorder, or bipolar disorder
Time of Update: 2022-04-22
In a study published today in JAHA, the leading journal in the field of cardiovascular disease, researchers aimed to compare estimated BMIs in patients with and without severe mental illness (SMI; bipolar disorder, schizophrenia, or schizoaffective disorder).
-
Crit Care: Distribution of motor subtypes of delirium in the intensive care unit
Time of Update: 2022-04-22
Delirium is the most common brain dysfunction in the intensive care unit (ICU) and can be subdivided into hypoactive, hyperactive, or mixed motor subtypes based on clinical presentation .
Research designCONCLUSIONS: Hypoactive delirium is the most common motor subtype in critically ill patients .
-
JNER: Effects of robotic assistance levels on upper extremity function in stroke patients undergoing assisted robotic rehabilitation, an analysis of a randomized clinical trial
Time of Update: 2022-04-22
Intervention group consisting of stroke survivors with severe to moderate stroke (FMA) Dendrogram of two different clustersDendrogram of two different clustersBased on the current and previous findings, the necessary methods to implement robotic assistance should be encouraged, given the level of voluntary movement that can be performed by stroke survivors with UE paraplegia during robotic therapy .
-
Neurology: Cerebrovascular reactivity is a core feature of cerebral amyloid angiopathy or a biomarker for assessing disease severity and cognitive impairment
Time of Update: 2022-04-22
In this cross-sectional study design , patients with probable cerebral amyloid angiopathy, mild cognitive impairment, Alzheimer's disease dementia and healthy controls underwent neuropsychological testing and MRI, including 5% carbon dioxide challenge .
-
Neurology: Serum β-synuclein concentration is significantly elevated in patients with Creutzfeldt-Jakob disease (CJD), which is expected to be a blood biomarker for early diagnosis and monitoring of synaptic integrity in CJD
Time of Update: 2022-04-22
In this regard, cerebrospinal fluid (CSF) markers, such as total tau, protein 14-3-3, neurofilament light chain protein (NFL) , chitotriosidase and chitinase 3-like 1, are better predictors of disease Severity and occurrence and evolution of neurodegeneration and neuroinflammation in the presymptomatic and symptomatic phases of prion disease .
-
Neurology: Neurosarcoidosis prognosis correlates with lesion location, and tumor necrosis factor alpha antagonists are superior to corticosteroids alone
Time of Update: 2022-04-22
Meningeal-localized sarcoidosis was associated with poorer prognosis in terms of recurrence or progression rates; tumor necrosis factor alpha antagonists were significantly lower than corticosteroids alone; methotrexate was more effective than azathioprine .
-
Why doesn't Putin walk with his right arm?
Time of Update: 2022-04-22
Case 2: Dmitry MedvedevCase 2: Dmitry Medvedev Case 2: Dmitry MedvedevMedvedev, Russia's prime minister, had no formal military training, but his right arm swayed noticeably less as he walked the red carpet at his presidential inauguration, suggested Putin as president and walked side by side with Putin .
-
Cerebral Cortex: Subcortical-cortical functional connectivity as a potential biomarker to identify patients with functional dyspepsia
Time of Update: 2022-04-22
1093/cercor/bhab419Tao Yin, Ruirui Sun, Zhaoxuan He, Yuan Chen, Shuai Yin, Xiaoyan Liu, Jin Lu, Peihong Ma, Tingting Zhang, Liuyang Huang, Yuzhu Qu, Xueling Suo, Du Lei, Qiyong Gong, Fanrong Liang, Shenghong Li, Fang Zeng , Subcortical–Cortical Functional Connectivity as a Potential Biomarker for Identifying Patients with Functional Dyspepsia, Cerebral Cortex https://doi.
-
Communications Biology: 7 hours of sleep a day is best for executive function and brain structure
Time of Update: 2022-04-22
published a research article entitled Impact of sleep duration on executive function and brain structure in the journal Communications Biology, investigating the relationship between sleep duration and cognitive performance in 479,420 healthy individuals aged 38-73.
-
The Lancet Neurol: Association of soluble TREM2 with other markers of autosomal dominant Alzheimer's disease and cognitive function
Time of Update: 2022-04-21
TREM2 is protective against Alzheimer's diseaseThe aim of this study was to investigate the dynamics of soluble TREM2 (as a biomarker of TREM2 signaling) and amyloid beta (aβ) deposition, taue-related pathology, neuroimaging during autosomal dominant Alzheimer's disease progression Correlations between biological markers and cognitive decline .
-
JPD: What are the characteristics of long-term changes in cognitive and motor impairment in Parkinson's patients?
Time of Update: 2022-04-21
Likewise, motor phenotype may also influence the progression of cognitive impairment, as evidence suggests that patients with PIGD not only exhibit faster cognitive decline, but also have a greater risk of dementia and higher rates of depression .
-
JPD: 20 years of follow-up, how have Parkinson's-related psychiatric disorders changed?
Time of Update: 2022-04-21
4% increased risk of death compared with women, while no significant gender differences were observed between men and women with PDP .
The significance of the study is that it found that, compared with PD patients, PDP increased the odds of death .
-
In the event of hypertensive cerebral hemorrhage, the multidisciplinary "guidelines and consensus" must be kept in mind!
Time of Update: 2022-04-21
For patients with supratentorial HICH , if severe intracranial hypertension or even brain herniation occurs, emergency surgery should be performed to remove the hematoma; hematoma removal can reduce the mortality rate and improve neurological prognosis to a certain extent ( Class I recommendation, Level A evidence) .
-
Neurology: A lot of cognitive reserve, or beneficial to reverse mild cognitive impairment!
Time of Update: 2022-04-21
Age, APOE, and underlying measures of cognitive reserve were estimated: RRs of regression and progression for education, academic performance (high school grades), and written language skills (idea density, grammatical complexity) .
-
Neurology: Disruption of WM connectivity in frontal and posterior cortical regions in Parkinson's disease may suggest early dementia transformation of PD-MCI
Time of Update: 2022-04-21
The present study demonstrates that disruption of WM connectivity in frontal and posterior cortical regions associated with frontal/executive dysfunction is associated with early dementia transformation in PD-MCI .
-
Alzheimers Dementia: Follow-up of 20,000 people for 20 years, before and after dementia diagnosis, what about medical expenditures?
Time of Update: 2022-04-21
They found that mean medical costs per person per year in the dementia group were consistently higher before diagnosis (10 years ago, SEK 2063, P < .
Average medical costs per person per year in the dementia group were consistently higher before diagnosis (10 years ago, SEK 2063, P < .
