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Lancet sub-journal: A large cohort of 80,000 people suggests that these 20 symptoms are red flags before Alzheimer's is diagnosed!
Time of Update: 2022-04-22
references:Identifying health conditions associated with Alzheimer's disease up to 15 years before diagnosis: an agnostic study of French and British health records.
1016/S2589-7500(21)00275-2Identifying health conditions associated with Alzheimer's disease up to 15 years before diagnosis: an agnostic study of French and British health records.
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JPD: Parkinson's patients, self-reported vision problems, can seriously affect quality of life
Time of Update: 2022-04-22
Hereby, Iris van der Lijna et al from the University of Groningen in the Netherlands conducted a systematic review of self-reported visual complaints in PD patients and healthy controls .
Self-Reported Visual Complaints in People with Parkinson's Disease: A Systematic Review.
3233/ JPD-202324 Self-Reported Visual Complaints in People with Parkinson's Disease: A Systematic Review.
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Alzheimers Dementia: Cerebrospinal fluid marker that predicts long-term neuropsychiatric symptoms
Time of Update: 2022-04-22
Lower CSF Aβ42, higher t-tau/Aβ42 and p-tau/Aβ42 ratios were associated with BDI-II and BAI total scores, clinical depression (BDI-II≥13) and clinical anxiety (BAI≥10) and NPI- Q-assessed anxiety and apathy .
Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging .
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Eur Heart J: Efficacy of oral anticoagulants in patients with atrial fibrillation at low stroke risk
Time of Update: 2022-04-22
There is currently no consensus on whether patients with atrial fibrillation (AF) at lower risk of stroke (a gender-independent CHA2DS2-VASc score) should receive oral anticoagulation .
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Stroke: After successful reperfusion with endovascular therapy, the greater the drop in blood pressure, the better the outcome!
Time of Update: 2022-04-22
To assess the relationship between changes in systolic blood pressure (ΔSBP) at different time intervals after successful reperfusion and imaging and clinical outcomes, a joint study was conducted by experts from the Department of Neurology at the University of Washington and the Department of Neurosurgery at the Medical University of South Carolina, The results were published in the journal Stroke .
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Movement disorders: Limbic system serotonergic plasticity that contributes to apathy in Parkinson's disease
Time of Update: 2022-04-22
Previous studies have demonstrated that newly diagnosed untreated (de novo) Parkinson's disease patients with apathy, depression, and anxiety have prominent seroergic dysfunction compared with patients without neuropsychiatric symptoms, and medial limbic cortex- Early striatal-pallidal-thalamic circuits are associated with specific microstructural alterations, whereas substantia nigra dopaminergic degeneration is similar .
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Neurology: Large Prospective Multicenter Stroke Study: Acute Stroke (AIS) Patients with Early Consciousness Disorder (ECD) Have Higher Mortality, Worse Discharge Outcomes, and Mortality Is More Associated with Life-Sustaining Treatment
Time of Update: 2022-04-22
StrokeAcute Ischemic Stroke (AIS) Life Sustaining Treatment (WOLST) Early Consciousness Disorder (ECD) We sought to assess the prognostic impact of ECD after AIS using data from the Florida Stroke Registry Hospital-Stroke Guidelines -Stroke® (GWTG-S) study participating in the AHA GET .
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Alzheimers Dementia: Walking speed, predictive of cognitive decline in advance
Time of Update: 2022-04-22
These results suggest that a decline in gait speed precedes cognitive decline , is associated with Alzheimer's pathology, and may be used for early detection of increased risk of dementia development .
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Migraines are "headaches"!
Time of Update: 2022-04-22
According to the results, there was a statistically significant inverse relationship between migraine and breast cancer in the case-control study [ HR 0.
Figure 2 In a case-control study, there was a statistically significant inverse relationship between migraine and breast cancer, HR0.
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Neurology: No-reflow phenomenon after successful thrombectomy, a new target for therapy?
Time of Update: 2022-04-22
In patients with successful thrombectomy, no-reflow was manifested by a decrease in rCBV or rCBF within the infarct on follow-up imaging (dark blue on perfusion imaging indicates lower values) .
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Neurology: Endoluminal biopsy can obtain a molecular map of brain arteriovenous malformation (bAVM), identify underlying gene expression signaling abnormalities, or help achieve precision medicine treatment!
Time of Update: 2022-04-22
To address this hurdle in the translation of precision medicine in human cerebral vasculature, a study published in Neurology attempted to use the diagnostic gold standard of cerebral angiography, namely sampling cells from the vascular lumen from within the cerebral vasculature, to demonstrate cerebral angiography-guided Feasibility and accuracy of intraluminal biopsy, molecular profiling of bAVMs using next-generation RNA sequencing (RNAseq) , identification of therapeutically targeted pathways, and inference of flow-mediated transcriptional alterations from unruptured bAVMs in living patients .
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JAMA sub-journal: Study of more than 20,000 people finds that LDL-C less than 1.8 mmol/L may reduce recurrent stroke
Time of Update: 2022-04-22
8 mmol/L may reduce the risk of recurrent strokeJAMAA recent meta-analysis published in JAMA Neurology found that low-density lipoprotein cholesterol (LDL-C)-lowering statin therapy may reduce the risk of recurrent stroke in patients with a history of ischemic stroke, but The risk of hemorrhagic stroke is increased .
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stroke: Tiantan Hospital: Survey of 10,000 stroke patients in China, what is the difference in prognosis between men and women?
Time of Update: 2022-04-22
In contrast, other studies have shown that female stroke survivors have higher in-hospital mortality and significantly worse functional outcomes .
, of Beijing Tiantan Hospital, explored gender differences in stroke outcomes, including stroke recurrence, mortality, and functional outcomes at 3, 6, and 12 months after stroke, a large multi-disciplinary study.
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Neurology: Mechanical thrombectomy vs bridging therapy: stroke patients with anterior circulation large vessel occlusion are more inclined to use BT, with better functional independence, reperfusion success rate, and mortality indicators
Time of Update: 2022-04-22
Previous randomized controlled trials (RCTs) have confirmed the good efficacy and safety of mechanical thrombectomy (MT) in the treatment of patients with anterior circulation stroke caused by large vessel occlusion (LVO) .
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Radiology: Diagnostic value of synthetic FLAIR sequences in acute ischemic stroke
Time of Update: 2022-04-22
(C) 86-year-old female , a sudden onset of right hemiparesis at 5 hours and 10 minutes prior to MRI , with no DWI-FLAIR mismatch on synthetic FLAIR and real FLAIR images .
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JAHA: Antithrombotic therapy after intracranial hemorrhage in patients with atrial fibrillation
Time of Update: 2022-04-22
CONCLUSIONS: OACs are recommended for patients with atrial fibrillation and intracranial hemorrhage because they reduce the risk of IS without increasing the risk of subsequent ICH .
OACs are recommended for patients with atrial fibrillation and intracranial hemorrhage because they reduce the risk of IS without increasing the risk of subsequent ICH .
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Epilepsia: thalamic functional connectivity predicts seizure recurrence after antiepileptic drug discontinuation
Time of Update: 2022-04-22
To investigate the characteristics of thalamocortical functional connectivity during epilepsy recurrence after antiepileptic drug withdrawal .
To investigate the characteristics of thalamocortical functional connectivity during epilepsy recurrence after antiepileptic drug withdrawal .
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Good news for insomnia patients, CHMP recommends dual-acting orexin receptor antagonist Quviviq
Time of Update: 2022-04-22
The Lancet results showed that daridorexant 25 mg and 50 mg improved sleep outcomes, and daridorexant 50 mg also improved daytime function in patients with insomnia with a favorable safety profile .
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Alzheimers Dement: Neurodegenerative protein in blood that predicts dementia early
Time of Update: 2022-04-22
, of Heidelberg University, Germany, explored the association between plasma-measured p-tau181, GFAP, and NfL levels at baseline and the risk of clinical AD in a community cohort study, and by association with vascular dementia (VD) and mixed dementia (MD) incidence rates to assess disease specificity, while exploring the effects of baseline cardiovascular health and APOE genotype on the association between plasma biomarkers and dementia risk .
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Molecular Psychiatry: Adverse Childhood Experiences Linked to Depression
Time of Update: 2022-04-22
published a research article in Molecular Psychiatry, Adverse childhood experiences and severity levels of inflammation and depression from childhood to young adulthood: a longitudinal cohort study, examining the association of several adverse childhood experiences in different early life stages with inflammation and depression in early adolescence longitudinal associations of longitudinal patterns and assessed the mediating role of inflammation .
