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Follow NICE guidelines to quickly master the diagnosis and treatment of primary headache
Time of Update: 2022-06-04
The headache diary should allow the patient to keep track of the following 5 points for at least 8 weeks: 1) headache frequency, duration, severity 2) any accompanying symptoms 3) all prescription and over-the-counter medications taken to relieve headache 4) possible exacerbating factors 5) headache Relationship with menstruation (female patients) 02 Diagnosis of the three major primary headaches (tension-type headache, migraine, cluster headache), please refer to the characteristics given in Table 2 .
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Study discovers new pathology of mitochondrial lysosomal exocytosis in Parkinson's disease
Time of Update: 2022-06-04
This work discovers a novel mitochondrial quality control mode independent of mitophagy in Parkinson's disease, and establishes a new compound-based method for the preparation of mitochondria-free cells without genetic manipulation .
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J Neuroinflammation︱Peng Ying's research group reveals the regulatory role of microglia mitophagy in morphine-induced central nervous system inflammatory inhibition
Time of Update: 2022-06-04
This paper proposes that NLRX1 protein mediates the occurrence of incomplete mitophagy in microglia and participates in the regulation of chronic morphine exposure-induced inflammatory suppression in the central nervous system .
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How does a brain that doesn't get out of control come about?
Time of Update: 2022-06-03
Recently, new research in Cell Reports has identified two more proteins involved in the regulation of brain signals, RIM1 and SRPK2, which are mainly responsible for controlling signal transmission at synaptic sites .
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Science sub-journal: Stress costs the cerebellum?
Time of Update: 2022-06-03
Activation of locus coeruleus neurons by optogenetic techniques promotes the onset of dyskinesia in wobbling mice, and intracerebellar injection of α1-adrenergic receptor antagonists can reduce the number of seizures, further indicating that stress-induced dyskinesia onset is dependent on epinephrine energy signal .
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There is a secret passage between your skull and your brain
Time of Update: 2022-06-03
In 2018, a medical team showed that in mouse and human brains, tiny channels connect the bone marrow of the skull to the meninges .
The researchers discovered these tiny channels when they set out to investigate whether immune cells from them were transported to the brain after a stroke or meningitis .
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Brain: A hodgepodge?
Time of Update: 2022-06-03
Brain regions associated with anxiety and fear memory circuits were highly activated during the acute phase of the disease: CeA and vBNST (bed nucleus of stria terminalis), while neuronal activity in the BLA region was reduced .
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This type of cerebral cortical infarction and hemorrhage, the etiology is too rare...
Time of Update: 2022-06-02
For reference only by medical professionals When clinically encountering headaches, focal neurological deficits, epilepsy, or patients with such imaging findings, the possibility of cortical venous thrombosis should be considered .
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Review of Front Aging Neurosci︱Astrocytes in the neurovascular unit after cerebral ischemia
Time of Update: 2022-06-02
NVU is composed of neurons, Ast, microglia (MG), BBB and extracellular matrix (ECM), and plays a role in the maintenance of normal brain function and the treatment of various brain diseases including ischemic stroke important .
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Clinical reasoning in a 37-year-old man with involuntary movements, gait disturbance, and hyperesthesia
Time of Update: 2022-06-02
The latest issue of Neurology's Clinical Reasoning Series reports a middle-aged male patient with involuntary movements, gait disturbance, and hyperesthesia.
The second group of patients presented with a slowly progressive pan-cerebellar syndrome involving speech, eye movements, and marked ataxia of the trunk and extremities .
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Patients with atrial fibrillation are at high risk of bleeding. How to prevent stroke?
Time of Update: 2022-06-02
For medical professionals to read and refer to clinical information only, long-term oral anticoagulants (OACs) are necessary measures to prevent stroke in patients with atrial fibrillation (AF) .
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A study of 360,000 people found that getting enough sun a day has the lowest risk of dementia
Time of Update: 2022-06-02
In order to better understand these issues, we are honored to invite Professor Yu Jintai, the corresponding author of the study, from the Department of Neurology, Huashan Hospital Affiliated to Fudan University, to further analyze the relationship between sunlight exposure and dementia risk reduction.
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HBM︱Region-based spatial standardization method of brain MRI images to achieve accurate registration of brain regions
Time of Update: 2022-06-02
(Credit: He H & Razlighi Q, Human Brain Mapping, 2022) The researchers also used functional MRI data to evaluate the spatially normalized results of the LG-RBSN .
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Front Aging Neurosci︱Sun Tao's research group proposes a new protocol for 11C-PiB-PET imaging for early diagnosis of Alzheimer's disease
Time of Update: 2022-05-31
Written by ︱ Sun Tao edited ︱ Sizhen Wang The diagnosis of Alzheimer's disease (AD) is usually based on clinical symptoms, while some pathological biomarkers such as amyloid-beta plaque and neurofibr
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Long-term outcomes and quality of life in stroke patients with extensive early infarction
Time of Update: 2022-05-31
*Clinical information for medical professionals only, 1s reach ▎Clinical question: In stroke patients with extensive early infarction, what is the correlation between reperfusion grade and long-term functional outcomes and long-term health-related quality of life?
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ANBR Review by Li Fangyuan & Ling Daishun's Team
Time of Update: 2022-05-31
Based on this, Professor Li Fangyuan's team from Zhejiang University School of Pharmacy and Professor Ling Daishun's team from the Center for Transformative Molecular Frontier Science of Shanghai Jiao Tong University discussed the use of effective brain ion level detection and dynamic change monitoring methods to help diagnose neurodegenerative diseases .
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Cell Research Li Dan/Wang Jian/Liu Cong collaborated to discover and characterize novel pathological protein fibril aggregates formed by TMEM106B in the human brain
Time of Update: 2022-05-31
In this study, researchers discovered a previously unknown cluster of novel pathological proteins extracted directly from the brain tissue of a Parkinson's disease dementia (PDD) patient with dementia and two elderly healthy controls.
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Neuron: Oxytocin-mediated neural circuit plasticity in parent-child behavior
Time of Update: 2022-05-31
In general, unmated male mice attacked the pups, but after transitioning to 'parents', oxytocinergic neurons in the PVH region of male mice received more excitatory structural input from the LHA region, excitatory Synaptic transmission was also enhanced, reducing behavior in aggressive pups, suggesting that plasticity in the structure of synaptic connections in neural circuits may serve as a structural basis for plasticity in parent-child behavior .
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The memory process of the brain is doing data compression, and different graphics also have a common memory format
Time of Update: 2022-05-31
This also confirms a conjecture of the researchers: the image properties of raster tilt and point set movement are both different and similar, but in the process of working memory, the brain will only extract the features most relevant to the specific task, and will Two different stimuli are encoded into the same "storage format" .
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Master the diagnosis and treatment of essential tremor
Time of Update: 2022-05-31
Unlike Parkinson's disease, resting tremor is a late feature in patients with essential tremor, who have significant movement tremors but only develop along the arms (ie, not the legs) .
