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How Cell Metabolism Controls Appetite at the Source—Providing New Approaches to Diabetes and Obesity Treatment
Time of Update: 2022-06-08
Chopra from the Harrington Institute for Discovery in the United States published an article titled Protein tyrosine phosphatase receptor d serves as the orexigenic asprosin receptor in the journal Cell Metabolism, identifying the receptor that regulates the orexigenic activity of Asprosin— - protein tyrosine phosphatase receptor d (Ptprd) .
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PNAS: What do you want to eat, it may just be your gut flora wanting to eat
Time of Update: 2022-06-08
On April 19, 2022, researchers from the University of Pittsburgh published a research paper titled: The gut microbiome influences host diet selection behavior in the Proceedings of the National Academy of Sciences (PNAS) .
The study found that gut microbes influence the host's food choices by producing substances that crave different types of food .
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The patient suffered from persistent headaches and a sudden loss of consciousness during the examination, for reasons no one could have imagined.
Time of Update: 2022-06-07
. I've always suspected that there was something wrong, such as the most common type of cerebral hemorrhage, in this middle-aged patient, who was at ease and responsive, because the patient not only had high blood pressure, persistent headaches, but also frequent vomiting .
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Neurosci Bull︱Qian Lingjia's research group reveals that homocysteine affects cognitive function by regulating DNA methylation during chronic stress
Time of Update: 2022-06-07
The authors found that chronic stress induces cognitive impairment, and that elevated Hcy is an important cause of cognitive impairment, while the level of brain-derived neurotrophic factor (BDNF) in the hippocampus decreases; further mechanisms Studies have found that elevated Hcy inhibits the transcription and expression of BDNF in the hippocampus by affecting the methylation modification of BDNF promoter DNA 5mC, which ultimately leads to cognitive impairment .
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Why does Alzheimer's disease kill so many brain cells?
Time of Update: 2022-06-07
But in this study, the scientists found that, affected by Alzheimer's disease, the somatic mutations accumulated in nerve cells in the brains of patients were abnormal in both speed and type .
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A chart summary article teaches you to distinguish between primary and secondary headaches
Time of Update: 2022-06-07
In the emergency department, although 95% of headache patients are primary, it is necessary to carefully exclude secondary causes that require urgent intervention, such as meningitis, subarachnoid hemorrhage, angle-closure glaucoma, and cerebral artery dissection [7] .
Common Primary and Secondary Causes of Headache in the Elderly[J].
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Cell Res: Tsinghua University Wang Gelin/Tang Yefeng develop NAD activator to protect nerves effectively
Time of Update: 2022-06-07
Nicotinamide adenine dinucleotide (NAD) is a very important coenzyme in the redox reaction of organisms and plays a vital role in various biological processes including metabolism, aging, cell death, DNA repair and gene expression.
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Do you know the imaging manifestations of cerebral aspergillosis?
Time of Update: 2022-06-07
Source: Department of Radiology, High Specialty Regional Hospital of elBajio, Mexico, 2019 Imaging findings: Brain magnetic resonance imaging (Figure 2) shows an irregularly shaped right frontal lobe lesion with blurred margins, peripheral vasogenic edema, and some Area of hemorrhage; despite the size of the lesion and extensive vasogenic edema, the mass effect was mild .
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Stem cells reproduce a new controversy?
Time of Update: 2022-06-07
The researchers found severe lipofuscin accumulation in more than 90% of neurons in the amygdala region by post-mortem tissue from healthy adults (50-86 years old), but there were still 3.
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Certain beta-blockers may reduce Alzheimer's risk
Time of Update: 2022-06-06
Molano, MD Hypertensive patients taking blood-brain barrier permeability comparison The risk of Alzheimer's disease is lower with high beta-blockers than with less penetrant beta-blockers .
Patients taking beta-blockers with low, moderate, or high BBB permeability had a similar risk of developing all-cause dementia .
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Enhanced MRI - "Searching Radar" in Brain Glioma Diagnosis and Treatment!
Time of Update: 2022-06-06
Through imaging detection techniques including enhanced MRI, clinicians have made more precise localization of the patient's lesions, thereby assisting doctors in performing surgical treatment for the patient more smoothly.
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Professor Zhu Yicheng's team "The Lancet" sub-journal revealed: China's 2019-2020 AIS intravenous thrombolysis rate was 5.64%, and the endovascular treatment rate was 1.45%
Time of Update: 2022-06-06
The Office of the Brain Prevention Committee of the National Health and Health Commission, in conjunction with the team of Professor Zhu Yicheng of Peking Union Medical College Hospital, conducted an in-depth analysis based on the data directly reported by stroke centers of more than 1,700 second-level and above hospitals on the China Cerebrovascular Disease Big Data Platform .
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Henan University Shi Bingyang's team developed a new type of nanocapsules, breaking the blood-brain barrier and efficiently editing brain tumor cells
Time of Update: 2022-06-06
Zheng Meng from the Henan University-Macquarie University Biomedical Joint Innovation Center from the School of Life Sciences, Henan University, as co-corresponding authors, published a paper entitled: Blood-brain barrier–penetrating in Science Advances, a sub-journal of Science Research paper on single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy .
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Curr Biol︱ Novelty detection and surprise in relation to recency in the primate brain
Time of Update: 2022-06-05
Previous studies have proposed several theories and models of novelty detection in the brain, each of which makes different predictions about the nature of neurons in the brain that respond to novel objects (Fig.
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Cell Stem Cell Human-derived pluripotent stem cells remodel the midbrain dopamine pathway
Time of Update: 2022-06-05
Parish from the University of Melbourne, Australia published an article entitled A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells in Cell Stem Cell, which successfully passed the Pluripotent stem cell transplantation precisely remodeled dopamine neurons and their neural pathways, thereby effectively restoring motor function in Parkinson's disease model mice .
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JHM Column Chen Chunhai and Zhou Zhou's team: The key role of SOX2-regulated astrocyte neurite plasticity in arsenic-induced metabolic disorders
Time of Update: 2022-06-05
This study found that chronic arsenic exposure can reduce Glucose sensing in hypothalamic POMC neurons by impairing SOX2-regulated astrocytic process plasticity, thereby inducing metabolic disorders in mice.
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AMEM adult hippocampal neurogenesis and neuroregenerative therapy for Alzheimer's disease
Time of Update: 2022-06-04
Figure 2: Summary diagram of potential neuroregenerative therapies In addition, this paper also reviews the research progress of inducing neurogenesis in AD brain by cell transplantation and inducing glial reprogramming, and analyzes its role in compensating for neuronal loss and remodeling.
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Professor Ren Liankun's team of Brain Stimulation published the latest research online: the first time to propose a new strategy for the treatment of epilepsy in children with BECTS
Time of Update: 2022-06-04
Aiming at the most common type of BECTS epilepsy in children, Ren Liankun's research group from the Epilepsy Team of Xuanwu Hospital of Capital Medical University has created a new non-invasive and non-drug-controlled treatment program internationally through proof-of-concept research .
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Risk of ischemic stroke may transiently increase during metoclopramide initiation
Time of Update: 2022-06-04
This article is from NEJM Journal Watch Risk For Ischemic Stroke Might Increase Briefly After Starting Metoclopramide May Briefly Increase Risk of Ischemic Stroke During Metoclopramide Initiation Review by Bruce Soloway, MD Inform patients of risks and other well-known neurological side effects .
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A case of "stroke" with epilepsy-like onset sharing experience in diagnosis and treatment case Shenghui
Time of Update: 2022-06-04
The recommended time window for emergency interventional therapy is 6-24 hours after onset, which can be used as a treatment plan for patients with contraindications to intravenous thrombolysis, and is more effective for intracranial large vessel occlusion [1] .
