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A new treatment option under the normalization of the epidemic--Ozamod treated patients can generate an effective immune response after being vaccinated against the new crown
Time of Update: 2022-06-11
Based on the drug mechanism and clinical studies with small sample size, the consensus pointed out that beta-interferon, teriflunomide, and dimethyl fumarate will not affect the effectiveness of the new crown vaccine, while receiving sphingosine-1-phosphate (S1P) Efficacy of vaccination in MS patients treated with body modulators (including fingolimod, siponimod) and anti-CD20 monoclonal antibodies (rituximab and its biosimilars, ofatumumab) may have declined .
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Case Reports and Comments Clippers Syndrome
Time of Update: 2022-06-10
Background Steroid-responsive chronic lymphocytic inflammation with ponto-cerebellar perivascular enhancement syndrome (Clippers syndrome) is a rare inflammatory disorder of the central nervous system that primarily affects the brainstem, especially the pons and adjacent regions such as the cerebellum .
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Neurology: Longitudinal trajectories of cardiovascular risk associated with cognitive decline and dementia events
Time of Update: 2022-06-10
*For medical professionals to read and reference clinical information, 1s touches ▎Clinical question: How is the longitudinal trajectory of cardiovascular risk associated with cognitive decline and dementia events?
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Neurology: "Ticagrelor + Aspirin" in the treatment of ischemic stroke, the benefits outweigh the disadvantages?
Time of Update: 2022-06-10
*For medical professionals to read and reference clinical information only, 1s touches a new study published in Neurology.
The THALES trial investigated ticagrelor combined with aspirin in the treatment of acute mild to moderate ischemic stroke or Short-term benefits and risks of transient ischemic attack (TIA) .
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Good news: ADAPT+ research results debut at AAN conference, efgartigimod is also effective and safe for long-term treatment of myasthenia gravis!
Time of Update: 2022-06-10
The results of the ADAPT+ study can preliminarily demonstrate that long-term treatment with efgartigmod has good efficacy in both AChR antibody-positive and negative gMG patients, providing sustained and reproducible clinically meaningful improvements in function and strength, while maintaining good tolerance.
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Somatic Single Nucleotide Variation in Alzheimer's Patients
Time of Update: 2022-06-10
Collectively, this work reveals the signature of sSNVs in AD patient neurons by scWGS analysis of 319 neurons, and these specific mutational patterns provide clues to their cause and potential impact in AD pathogenesis as well as therapeutic targets Points such as the marked increase in signature C are consistent with reports of significant levels of oxidative damage in AD .
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Is your tongue "dancing" after taking hiccups?
Time of Update: 2022-06-10
5. How to diagnose TD The diagnosis of this disease is based on the patient's history of taking antipsychotics or long-term use of antidepressants, antiparkinsonian drugs, antiepileptic drugs or antihistamines, and the occurrence of dyskinesia during medication or within 3 months after withdrawal , showing rhythmic stereotyped repetitive persistent involuntary movements .
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Aging Cell︱Gao Xu's team found that good sleep quality can delay the accelerated aging caused by air pollution
Time of Update: 2022-06-10
On April 14, 2022, Xu Gao's team from Peking University School of Public Health published a paper entitled "Role of sleep quality in the acceleration of biological aging and its potential for preventive interaction on air pollution insults: Findings from the UK in the journal Aging Cell.
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Courier for Hearing Loss, Positive Phase 2a Clinical Results of BDNF Therapy
Time of Update: 2022-06-10
▎WuXi AppTec Content Team Editor A few days ago, Otonomy announced that its investigational therapy OTO-413 has achieved positive top-line results in a Phase 2a clinical trial in subjects with hearing loss .
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Does the ACD score predict long-term survival after status epilepticus?
Time of Update: 2022-06-10
We recently conducted a retrospective cohort study to assess whether the ACD score could predict long-term survival after status epilepticus .
Using the ACD score to account for risk factors for new neurological deficits is a reliable method for predicting long-term outcomes in patients with status epilepticus (no or less damage to the brain) .
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Autophagy︱Shen Hanming's group revealed a new mechanism of autophagy-related protein WIPI2 regulating mitochondrial outer membrane protein degradation and mitophagy
Time of Update: 2022-06-10
At the molecular level, WIPI2 interacts with the VCP-UFD1-NPLOC4 complex and promotes its recruitment to damaged mitochondria, thereby mediating the ubiquitin-proteasome-dependent degradation of mitochondrial outer membrane proteins and the occurrence of mitophagy ( Figure 6) .
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Nature sub-issue: Yang Yuanjian's team from Jiangxi Mental Health Center found that the longevity factor Klotho may have antidepressant potential
Time of Update: 2022-06-10
After specifically increasing the expression of Klotho protein in the NAc brain region by the viral vector tool, it can significantly improve the social impairment, anhedonia and other depression-like behaviors caused by chronic stress .
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Internal capsule, corpus callosum, basal ganglia... Lesion symptoms and location diagnosis diagram
Time of Update: 2022-06-10
Pseudobulbar palsy in the center of the hemisphere and semiovale, causing left-hand apraxia , and the fibers from the internal capsule to the head and face motor center of the right cerebral hemisphere cortex all pass through the middle of the corpus callosum, so when the middle of the corpus callosum is damaged, these fibers can be blocked at the same time, resulting in pseudobulbar palsy symptoms .
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J Hazard Mater Chen Chunhai/Zhou Zhou discovered the key mechanism of SOX2-regulated astrocyte neurite plasticity in arsenic-induced metabolic disorders
Time of Update: 2022-06-08
The research paper, by establishing a transgenic mouse model that specifically knocks out SOX2 expression in astrocytes, discovered the important role of SOX2-regulated astrocyte neurite plasticity in arsenic-induced metabolic disorders , and also confirmed that impaired astrocyte plasticity will significantly affect the glucose sensitivity of the leading hypothalamic POMC neurons, which will lead to the occurrence of metabolic disorders in mice .
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Cell Res Tsinghua University Wang Gelin/Tang Yefeng developed a small molecule activator of nicotinamide phosphoribosyltransferase, laying the foundation for the development of new anti-neurodegenerative disease therapeutics
Time of Update: 2022-06-08
Discovery and development of potent activators (NATs) of nicotinamide phosphoribosyltransferase (NAMPT), a rate-limiting enzyme in the NAD salvage pathway .
Here, we report the discovery of a chemical-like NAMPT activator (NAT) that promotes neural stem cell proliferation in vitro and exhibits neuroprotection in a preclinical mouse model of chemotherapy-induced peripheral neuropathy (CIPN) efficacy .
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Video Demonstration of Positional Test of BPPV and Repositioning for "Halo" Strategies Issue 5
Time of Update: 2022-06-08
. Video 1: Right Dix-Hallpike test If the patient has posterior semicircular canal BPPV, bilateral vertical torsional nystagmus occurs when the affected ear is turned to the ground (see Video 2) (the vertical component goes up to the pole, and the torsion component goes to the ground), with fatigue, And the torsional component of low nystagmus is more prominent, and the vertical component of high nystagmus is more obvious .
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The common causes of headaches, the Great God summed up 16 kinds, too complete!
Time of Update: 2022-06-08
Partly caused by increased intracranial pressure, localized or total headache, may be accompanied by other symptoms and signs of neurological deficits, such as severe nausea and vomiting, disturbance of consciousness, meningeal irritation, etc.
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AAV Gene Therapy Publishes Positive Preclinical Data, Direct Intracerebral Injection for Rare Diseases
Time of Update: 2022-06-08
Recommended reading: First-class AAV vector delivery, CNS-focused gene therapy completes first patient dosingYimai Meng broke the news Positive early clinical outcomes in deposition disease .
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PNAS: What do you want to eat, it may just be your gut flora wanting to eat
Time of Update: 2022-06-08
On April 19, 2022, researchers from the University of Pittsburgh published a research paper titled: The gut microbiome influences host diet selection behavior in the Proceedings of the National Academy of Sciences (PNAS) .
The study found that gut microbes influence the host's food choices by producing substances that crave different types of food .
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How Cell Metabolism Controls Appetite at the Source—Providing New Approaches to Diabetes and Obesity Treatment
Time of Update: 2022-06-08
Chopra from the Harrington Institute for Discovery in the United States published an article titled Protein tyrosine phosphatase receptor d serves as the orexigenic asprosin receptor in the journal Cell Metabolism, identifying the receptor that regulates the orexigenic activity of Asprosin— - protein tyrosine phosphatase receptor d (Ptprd) .
