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Nature Breakthrough!
Time of Update: 2022-09-06
Original link: Embryonic stem cells (ESCs) are often considered pluripotent cells because they can be cultured in vitro to many stages of mammalian embryogenesis, but their developmental potential can be greatly expanded through interactions with extraembryonic stem cells, including trophoblasts Stem cells (trophoblast stem cells, TSCs), extraembryonic endoderm stem cells (extraembryonic endoderm stem cells, XEN) and inducible-XEN cells (inducible-XEN cells, iXEN) .
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Science I Gu Ying/Fei Jifeng/Xu Xun/Chen Liang/Li Hanbo's team uses spatiotemporal transcriptome to reveal the key cell types and mechanisms of telencephalon regeneration in salamanders
Time of Update: 2022-09-06
For the first time, he drew a spatiotemporal single-cell map of the brain of a model animal, and further described the process of telencephalon regeneration at the spatiotemporal transcriptome level, and analyzed the cellular and molecular mechanisms of telencephalon regeneration in Mexican axolotl in detail, which is helpful for understanding mammalian brain regeneration.
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West syndrome (infantile spasms): signs and symptoms, etiology, epidemiology, diagnosis, and treatment
Time of Update: 2022-09-06
First, the general overviewWest syndrome is a group of symptoms characterized by epilepsy/infantile spasms, abnormal brainwave patterns (called hyperrhythmias), and intellectual disability.
First, the general overviewWest syndrome is a group of symptoms characterized by epilepsy/infantile spasms, abnormal brainwave patterns (called hyperrhythmias), and intellectual disability.
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Shifts in neural representations in social behavioral networks
Time of Update: 2022-08-20
BNSTpr Esr1 neurons control the transition from sniffing to riding or aggressive behavior by affecting gender- and behavior-specific neural representations in the hypothalamus MPOA and VMHvl .
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The Lancet Duo: Is Bridging Better Outcomes in Patients With Large Vessel Occlusion?
Time of Update: 2022-08-20
*For medical professional reading reference onlyAt the end of the article, there is a wonderful comment from Professor Dong Qiang of Huashan Hospital Affiliated to Fudan University, don't miss it~Whether intravenous thrombolysis should be performed before thrombectomy for acute large vessel occlusion is a hot and controversial point in the field of stroke treatment in recent years .
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Express Merck returns to the field of Alzheimer's disease, reaching about 1.1 billion US dollars in research and development cooperation
Time of Update: 2022-08-20
▎Edited by WuXi AppTec Content Team▲Introduction to the NETSseq technology platform (Image source: Cerevance's official website)References:[1] Cerevance Establishes Strategic Research Collaboration with Merck for the Discovery of Novel Targets in Alzheimer's Disease.
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Who is more likely to develop Alzheimer's disease?
Time of Update: 2022-08-20
A molecular analysis of human microglia by researchers at the Mount Sinai School of Medicine in New York has identified 21 genetic loci associated with Alzheimer's disease risk .
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Neuronsci Bull's point of view︱Application of brain-computer interface technology in diagnosis and treatment of disorders of consciousness
Time of Update: 2022-08-20
Due to the complex mechanisms of recovery after brain injury, further clinical validation is required to determine whether training with multimodal BCIs can promote neural remodeling and improve outcomes more rapidly in patients with DoCs .
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Does thalamic infarction cause "dementia"?
Time of Update: 2022-08-20
*For medical professional reading reference onlyCome and listen to the big coffee to explain the real case!According to the "China Stroke Report" released in 2020, about 1/3 of stroke patients in Chin
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The latest "Cell" of the University of Science and Technology of China: If this thing is missing after birth, why does it endanger the brain for life?
Time of Update: 2022-08-20
What is the neural mechanism of visual perception to promote brain development, and what are the adverse effects of lack of light on brain development?Image source: 123RF This week, in a new study published in the journal Cell, a research team led by Professor Xue Tian and Bao Jinte, a researcher at the University of Science and Technology of China, uncovered the neural mechanism by which visual perception promotes brain development .
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Immunity: Scientists reveal the developmental origin of disease-associated microglia and disease-inflammation-associated macrophages
Time of Update: 2022-08-20
004The pictures in the text are from the referenceClick on the blue word to follow usBrain macrophage populations include microglia, border-associated macrophages, and monocyte-derived cells, which together control brain development and homeostasis .
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Can tenecteplase be used for thrombolysis in acute ischemic stroke?
Time of Update: 2022-08-20
Tissue plasminogen activator (TPA, alteplase) has been approved for more than 25 years and is indicated for patients with acute ischemic stroke who meet the standard of care .
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Neocortical pyramidal neuron subtype diversity controls microglial state
Time of Update: 2022-08-20
Using single-cell and spatial transcriptome analysis, the study found that the state and distribution of microglia in the neocortex is determined by a specific subtype of nearby projection neurons (PN), and this neuron-microglia Communication between them is mediated by bidirectional ligand-receptor interactions .
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Two Aβ mAbs have been given priority review by the FDA. Can AD drugs turn the tide under the theoretical basis of the "Leaning Tower of Pisa"?
Time of Update: 2022-08-20
In March 2019, Biogen announced the early termination of two Phase 3 clinical trials of the drug because clinical data showed that aducanumab did not improve mild cognitive impairment in AD patients .
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After 10 years of involuntary movement of the whole body, the director clarified the diagnosis with a picture
Time of Update: 2022-08-20
What medical logic is based on the diagnosis and treatment of diseases?Case introductionConsciousness, communication is slightly difficult, physical examination cooperation, rough measurement of memory, comprehension, judgment, computing power decline .
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Cell: Xue Tian/Bao Jin's team revealed the neural mechanism of light perception to promote brain development
Time of Update: 2022-08-20
This study discovered the photoreceptors, neural circuits and molecular mechanisms that promote the coordinated development of neuronal synapses in the higher cognitive regions of the brain in early developmental visual (light) perception, and revealed the impact of early developmental light perception on the advanced cognitive abilities of the adult brain .
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Can't help but want to answer?
Time of Update: 2022-08-20
Xiao Xiao from the qubit of the concave temple | public account QbitAIWhen chatting, reading or listening to lectures, do you realize that you are crazy "brain supplement"?In fact, your brain is like
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It makes sense to fish: the brain accumulates toxins as soon as they think, and they must rest to clear them | Cell Sub-Journal
Time of Update: 2022-08-20
Please be sure to note your name-company-position when adding friends~Click here👇 to follow me, remember to mark the star~"Share", "Like" and "Watching" in one clickSee you every day at the forefront of science and technology~Mengchen is sent from the qubit of the concave temple | public account QbitAIIf you think hard, you will be mentally exhausted.
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Brain Behav Immun︱Ding Xu Reveals New Treatment Mechanism of Postoperative Pain Sensitization
Time of Update: 2022-08-20
, Brain Behav Immun, 2022)The team's previous research found that in neonatal and adult incision rats, BDNF increased in microglia in the dorsal horn of the spinal cord, which was involved in long-term potentiation and facilitation of synaptic transmission, and that surgical incision in the neonatal period caused postoperative pain in adulthood.
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Can the new use of cutting-edge old drugs bring a new dawn of treatment for this incurable disease?
Time of Update: 2022-08-20
▲If you have any business needs, please long press to scan the QR code above, or▎Edited by WuXi AppTec Content Team▲ Molecular formula of Terazosin (Image source: Fvasconcellos, Public domain, via Wikimedia Commons)WuXi AppTec provides integrated, end-to-end new drug R&D and production services for the global biopharmaceutical industry, covering chemical drug R&D and production, biological research, preclinical testing and clinical trial R&D, cell and gene therapy R&D, testing and production and other fields .
