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LANCET HEALTHY LONGEVITY: Is the brain healthy, look at the brain-PAD indicator
Time of Update: 2022-09-06
Specifically, the association of brain-PAD with five outcomes was investigated: measures of life course in childhood, middle age, and later life; imaging-based markers of neurodegeneration, including Alzheimer's disease and cerebrovascular disease; cognition capacity; blood biomarkers; and subsequent rates of brain atrophy .
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Front. Cell Dev: Bidirectional cycling between lysosomes and α-syn (bottom)
Time of Update: 2022-09-06
Compilation Author: Level 10 Fatty (Brainnews creative team) Reviewer: Simon (Brainnews Editorial Office) Lysosomal dysfunction exists in the brains of patients with Parkinson's disease, while the accumulation and aggregation of α-syn is the main pathogenesis of PD .
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Neurology: Zhu Yongjian's team found prognostic factors for spontaneous spinal epidural hematoma
Time of Update: 2022-09-06
Eighty-two patients (78%) had moderate to severe neurological impairment (Frankel scale AC) .
Poor prognostic factors for SSEH may include thoracic location, use of anticoagulants, severe neurological deficit on admission, sphincter dysfunction, and rapid progression .
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Circulation: Novel anticoagulants prevent recurrent ischemic stroke (PACIFIC-Stroke study)
Time of Update: 2022-09-06
Inclusion criteria: ECG documented atrial fibrillation at baseline or previous 12 months; male CHA2DS2-VASc score ≥2 (males) or ≥3 (females); those not currently receiving oral anticoagulant therapy or receiving at least one Bleeding risk profile in DOAC-treated patients with an indication for treatment with oral anticoagulants (history of previous bleeding requiring medical attention within 12 months, estimated glomerular filtration rate 30 to 50 mL/min, or current Indications for oral aspirin); age ≥ 45 years; able to provide informed consent .
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Time to relax!
Time of Update: 2022-09-06
The researchers found that after adjusting for factors such as age, sex, and education, leisure activities were associated with a lower risk of developing all-cause dementia, Alzheimer's disease, and vascular dementia .
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Neurology: A multivariate predictive model for recanalization failure in patients with acute ischemic stroke
Time of Update: 2022-09-06
Recently, a study published in Neurology sought to develop and validate a multivariate prognostic model to identify futility of recanalization therapy (FRT) in patients receiving these treatments .
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Neurology: Association of stroke lesion type and white matter hyperintensity with stroke severity and prognosis
Time of Update: 2022-09-06
0000000000200926 A study published in Neurology sought to investigate whether high white matter hyperintensity (WMH) burden is associated with higher stroke severity and worse functional outcomes .
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Stroke: How does flu-like illness and vaccination affect stroke in young adults?
Time of Update: 2022-09-06
The combined effect showed that ILI was associated with an increased risk of stroke in those with (aOR=1.
The combined effect showed that ILI was associated with an increased risk of stroke in those with (aOR=1.
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JAMA Neuro: Spatial extent of Aβ levels and correlation with Tau-PET and cognition
Time of Update: 2022-09-06
Compared with Aβ negatives, those with regional Aβ binding showed more APOE ε4 carriers (18 [64%] vs 22 [27%] PREVENT-AD and 34 [31%] vs 38 [19%] ] ADNI), decreased CSF Aβ1-42 levels (F = 24 and 71), and greater longitudinal Aβ-PET accumulation (significant β = 0.
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Alzheimer Dementia: Characterization of the Effects of Sample Processing on Alzheimer's Disease-Related Blood Biomarkers
Time of Update: 2022-09-06
references:Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease–related blood-based biomarkers: Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group Blood-based biomarkers for Alzheimer's disease (AD) have the potential to be implemented as a non-invasive screening tool .
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Movement disorders: The relationship between movement and cognitive metabolic networks in Parkinson's disease
Time of Update: 2022-09-06
Likewise, iPD patients' delta was compared to iRBD19 subjects as well as PD genotypes associated with LRRK2-G2019S mutation and GBA1 variant patients associated with slower and faster disease progression .
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Transl Psychiatry: A variety of blood test indicators are closely related to the incidence of dementia
Time of Update: 2022-09-06
Because dementia is a systemic disease associated with dysfunction of oxidative, inflammatory, and biochemical pathways in peripheral tissues, studies including comprehensive serum laboratory tests may provide evidence for exploring the pathophysiology of dementia and identifying biomarkers .
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Nearly 30 years of follow-up: Laparoscopy-proven endometriosis patients have a 34% increased risk of stroke
Time of Update: 2022-09-06
Recently, the Farland team from the Department of Epidemiology and Biostatistics at the University of Arizona published an important research result in the journal "Stroke" (Laparoscopically Confirmed Endometriosis and Risk of Incident Stroke: A Prospective Cohort Study.
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Aging Cell: Tumor suppressor miR-34c as a new target for AD therapy
Time of Update: 2022-09-06
1miR-34c is regulated by ROC-JNK-p53 and is associated with AD pathologyThe present study firstly determined the increased expression level of miR-34c in vivo (SAMP8 mouse model-aging accelerated model) and in vitro (H2O2-stimulated oxidative stress neurons and Aβ42-stimulated AD cell model) .
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Schizophrenia Bulletin: University of Manchester study finds COVID-19 mortality rates in people with severe mental illness remain high after vaccination
Time of Update: 2022-09-06
1093/schbul/sbac118 People with severe mental illness (SMI) die approximately 15 years younger than the general population, largely due to higher morbidity and mortality from physical illness in this vulnerable group .
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Stroke: Eight-year trajectory of depressive symptoms and the association of stroke risk
Time of Update: 2022-09-06
Taken together, depressive symptom trajectories characterized by high symptoms across multiple time points were associated with increased stroke risk .
Taken together, depressive symptom trajectories characterized by high symptoms across multiple time points were associated with increased stroke risk .
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How do visually impaired scientists do research?
Time of Update: 2022-09-06
The first group consisted of 5 visually impaired persons and 106 blindfolded persons with normal vision, who were to interpret the data on the 3D printed light-transmitting relief plate by touch;2.
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JNNP: Association of poor sleep with multiple sclerosis symptoms
Time of Update: 2022-09-06
Poor sleep quality is common among patients with multiple sclerosis (PwMS) (up to 67%, more common than the general population (33%-45%), associated with lower health-related quality of life (HRQoL), and higher community Mortality .
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Nature Breakthrough!
Time of Update: 2022-09-06
Original link: Embryonic stem cells (ESCs) are often considered pluripotent cells because they can be cultured in vitro to many stages of mammalian embryogenesis, but their developmental potential can be greatly expanded through interactions with extraembryonic stem cells, including trophoblasts Stem cells (trophoblast stem cells, TSCs), extraembryonic endoderm stem cells (extraembryonic endoderm stem cells, XEN) and inducible-XEN cells (inducible-XEN cells, iXEN) .
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Science I Gu Ying/Fei Jifeng/Xu Xun/Chen Liang/Li Hanbo's team uses spatiotemporal transcriptome to reveal the key cell types and mechanisms of telencephalon regeneration in salamanders
Time of Update: 2022-09-06
For the first time, he drew a spatiotemporal single-cell map of the brain of a model animal, and further described the process of telencephalon regeneration at the spatiotemporal transcriptome level, and analyzed the cellular and molecular mechanisms of telencephalon regeneration in Mexican axolotl in detail, which is helpful for understanding mammalian brain regeneration.
